Results 11 to 20 of about 45,415 (193)

Dual-Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration. [PDF]

Adv Sci (Weinh)
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Yan J, Lin Y, Miao S, Chao M, Dai C, Hao Z, Chen R, Guan M, Pan B, Gao F, Zhou Q.   +10 more
europepmc   +2 more sources

Impaired Chaperone-Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation. [PDF]

Adv Sci (Weinh)
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Chen X, Gao H, Wu W, Shi P, Chen Y, Zhang A, Cheng Z, Wu W, Yu Z, Zhang Y.   +9 more
europepmc   +2 more sources

A Decoy-Receptor-Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration. [PDF]

Adv Sci (Weinh)
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Li F, Zhang B, Zhang Z, Zheng B, Han L, Yan C, Li J, Sun K, Zhao T, Shi J.   +9 more
europepmc   +2 more sources

Ammonia Accumulation Drives Intervertebral Disc Degeneration by Triggering Ammonia-Induced Cell Death Through Lysosome-Mitochondria Crosstalk. [PDF]

Cell Prolif
Mechanical strain disrupts the lysosome‐mitochondria axis via GLS1‐mediated ammonia toxicity, causing NP cell death and ECM breakdown in IVDD. CB839‐mediated GLS1 inhibition effectively rescues cellular homeostasis and alleviates disc degeneration.
Zhang Y, Gao Y, Dong S, Liu S, Liu L, Song Z, Xu J, Rong Y, Song G, Zhang Y, Wu D, Gao Z.   +11 more
europepmc   +2 more sources

Identification and Experimental Validation of PANoptosis Key Genes for Constructing a PANoptosis Risk Diagnostic Model in Intervertebral Disc Degeneration. [PDF]

J Gene Med
This study identified seven PANoptosis key genes (ACSBG1, FXYD1, APCS, CEACAM1, ERAP2, ABL1, and FZD3) in intervertebral disc degeneration (IDD) through integrated bioinformatics analysis of GEO datasets. Using machine learning algorithms (RF, SVM, XGB, and GLM), a PANoptosis risk diagnostic model was constructed and validated.
Deng K, Lan X, Chen W, Du L, Chen J.
europepmc   +2 more sources

Evaluation of the influence of kyphosis and scoliosis on intervertebral disc extrusion in French bulldogs

BMC Veterinary Research, 2018
Background Although thoracic vertebral malformations with kyphosis and scoliosis are often considered incidental findings on diagnostic imaging studies of screw-tailed brachycephalic breeds, they have been suggested to interfere with spinal biomechanics ...
Maria Claudia C. M. Inglez de Souza, Richard Ryan, Gert ter Haar, Rowena M. A. Packer, Holger A. Volk, Steven De Decker   +5 more
doaj   +1 more source

Identification of Key Modules and Hub Genes of Annulus Fibrosus in Intervertebral Disc Degeneration

Frontiers in Genetics, 2021
Background: Intervertebral disc degeneration impairs the quality of patients lives. Even though there has been development of many therapeutic strategies, most of them remain unsatisfactory due to the limited understanding of the mechanisms that underlie
Hantao Wang, Hantao Wang, Wenhui Liu, Bo Yu, Xiaosheng Yu, Bin Chen   +5 more
doaj   +1 more source

Risk factors for postoperative complications after UBE surgery for thoracic spinal stenosis and construction of a nomogram predictive model

Frontiers in Neurology
BackgroundThis study aimed to develop and validate the first nomogram model for predicting postoperative complications in thoracic spinal stenosis (TSS) patients undergoing unilateral biportal endoscopy (UBE), integrating multidimensional risk factors to
Mingkui Shen, Mingkui Shen, Lulu Wang, Lulu Wang, Zhongxin Tang, Zhongxin Tang, Xiaohu Wang, Hejun Yang, Hejun Yang   +8 more
doaj   +1 more source

Novel therapeutic strategies for degenerative disc disease: Review of cell biology and intervertebral disc cell therapy

SAGE Open Medicine, 2018
Intervertebral disc degeneration is a disease of the discs connecting adjoining vertebrae in which structural damage leads to loss of disc integrity.
Joseph Fernandez-Moure, Caitlyn A Moore, Keemberly Kim, Azim Karim, Kevin Smith, Zonia Barbosa, Jeffrey Van Eps, Pranela Rameshwar, Bradley Weiner   +8 more
doaj   +1 more source

Gut microbiota orchestrates bone homeostasis: a multi-pathway network from intestine to skeleton

Frontiers in Endocrinology
Osteoporosis (OP), a widespread metabolic bone condition characterized by diminished bone mass and compromised microarchitecture, poses a significant global health challenge. The gut microbiota (GM) regulates bone homeostasis through the “gut-bone axis,”
Yanlong Gong, Xin Ma, Lele Wang, Pengwei Zhang, Tingting Liu, Yuanzhen Li, Wantao Dong   +6 more
doaj   +1 more source