Results 11 to 20 of about 43,248 (263)
Piezoelectricity in the Intervertebral disc
Journal of Biomechanics, 2020 Lower back pain is a major global health challenge that can often be caused by degeneration of the Intervertebral Disc (IVD). While IVD biomechanics are a key factor in the degenerative cycle, many mechanotransduction pathways remain unknown, in particular the electro-mechanical coupling in the loaded tissue. However, despite evidence for a role in the
Philip Poillot +6 more
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Inflammaging in the intervertebral disc [PDF]
Clinical and Translational Neuroscience, 2018 Degeneration of the intervertebral disc – triggered by ageing, mechanical stress, traumatic injury, infection, inflammation and other factors – has a significant role in the development of low back pain. Back pain not only has a high prevalence, but also a major socio-economic impact. With the ageing population, its occurrence and costs are expected to
Aleksandra Sadowska +2 more
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Mechanotransduction in intervertebral discs [PDF]
Journal of Cellular and Molecular Medicine, 2014 AbstractMechanotransduction plays a critical role in intracellular functioning—it allows cells to translate external physical forces into internal biochemical activities, thereby affecting processes ranging from proliferation and apoptosis to gene expression and protein synthesis in a complex web of interactions and reactions.
Tsai, Tsung-Ting +3 more
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Prolapsed intervertebral disc [PDF]
BMJ, 2008 Prolapsed intervertebral disc is common—it is seen in up to a quarter of magnetic resonance scans and can be detected even in asymptomatic adults.1 Disc prolapse is genetically driven—twin studies indicate that at least 60% of the variance can be explained on genetic grounds and not by the commonly assumed environmental factors (work, trauma, exposure ...
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Nutrition of the Intervertebral Disc
Spine, 2004 A review of the literature on disc nutrition.To summarize the information on disc nutrition in relation to disc degeneration.The disc is avascular, and the disc cells depend on diffusion from blood vessels at the disc's margins to supply the nutrients essential for cellular activity and viability and to remove metabolic wastes such as lactic acid.
Urban, J, Smith, S, Fairbank, J
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Molecular Pain, 2020 Background Recent studies have found that microRNAs (miRNAs) play a critical role in development and progression of intervertebral disc degeneration. In the present study, we examined the role of miR-185 in nucleus pulposus cell behavior in vitro and the
Zhennan Yun +5 more
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Identification of Key Modules and Hub Genes of Annulus Fibrosus in Intervertebral Disc Degeneration
Frontiers in Genetics, 2021 Background: Intervertebral disc degeneration impairs the quality of patients lives. Even though there has been development of many therapeutic strategies, most of them remain unsatisfactory due to the limited understanding of the mechanisms that underlie
Hantao Wang +5 more
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BMC Veterinary Research, 2018 Background Although thoracic vertebral malformations with kyphosis and scoliosis are often considered incidental findings on diagnostic imaging studies of screw-tailed brachycephalic breeds, they have been suggested to interfere with spinal biomechanics ...
Maria Claudia C. M. Inglez de Souza +5 more
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Frontiers in NeurologyBackgroundThis study aimed to develop and validate the first nomogram model for predicting postoperative complications in thoracic spinal stenosis (TSS) patients undergoing unilateral biportal endoscopy (UBE), integrating multidimensional risk factors to
Mingkui Shen +8 more
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SAGE Open Medicine, 2018 Intervertebral disc degeneration is a disease of the discs connecting adjoining vertebrae in which structural damage leads to loss of disc integrity.
Joseph Fernandez-Moure +8 more
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