Results 21 to 30 of about 43,248 (263)

Gut microbiota orchestrates bone homeostasis: a multi-pathway network from intestine to skeleton

Frontiers in Endocrinology
Osteoporosis (OP), a widespread metabolic bone condition characterized by diminished bone mass and compromised microarchitecture, poses a significant global health challenge. The gut microbiota (GM) regulates bone homeostasis through the “gut-bone axis,”
Yanlong Gong, Xin Ma, Lele Wang, Pengwei Zhang, Tingting Liu, Yuanzhen Li, Wantao Dong   +6 more
doaj   +1 more source

Methanolysis of the Intervertebral Disc

Clinical Chemistry, 1967
Abstract Methanolysis of intervertebral disc samples at 60° was largely hydrolysis as shown by the absence of methylated derivatives on chromatograms of the reaction products. Extent of the reaction increased with acid strength; the products were the same.
D, Chan, E W, Hull, M, Fields, E, McNall
openaire   +2 more sources

Research progress on macrophage polarization during the degeneration process of lumbar intervertebral discs [PDF]

Jichu yixue yu linchuang
During pathological progression of lumbar intervertebral disc degeneration (LIDD), macrophage polarization functions as a critical regulatory mechanism through the dynamic transition between M1 and M2 phenotypes.
CHEN Wang, LI Xugui, LI Ying
doaj   +1 more source

Cell Adhesion by Design: Engineering Tissue Culture Scaffolds With Adhesion Cues

Advanced Materials Interfaces, EarlyView.
ABSTRACT In scaffold‐based tissue engineering, the matrix should provide adequate adhesion cues for cell attachment, spreading, and function. Given the multitude of adhesion receptors and the diversity of scaffolds, there are many approaches to render scaffolds adhesive, even though they are not all equivalent.
Dalia Dranseike, Dhananjay V. Deshmukh, Mark W. Tibbitt, Céline Labouesse   +3 more
wiley   +1 more source

Development of a deep learning model for automatic detection of narrowed intervertebral disc space sites in caudal thoracic and lumbar lateral X-ray images of dogs

Frontiers in Veterinary Science
Intervertebral disc disease is the most common spinal cord-related disease in dogs, caused by disc material protrusion or extrusion that compresses the spinal cord, leading to clinical symptoms.
Junseol Park, Junseol Park, Hyunwoo Cho, Yewon Ji, Kichang Lee, Hakyoung Yoon, Hakyoung Yoon   +6 more
doaj   +1 more source

Interface‐Engineered Binary Framework Composites: Advancing Porous Materials for Precision Medicine

Advanced Materials Interfaces, EarlyView.
Binary framework composites integrate two complementary porous architectures into a unified platform, enabling multifunctional design, enhanced structural tunability, and improved physicochemical performance. By combining high surface area, ordered porosity, interfacial synergy, and versatile functionalization, these hybrid materials offer new ...
Navid Rabiee, Mohammad Rabiee, Mohammad Akrami‐Hasan‐Kohal, Sidi A. Bencherif   +3 more
wiley   +1 more source

Role of macrophage in intervertebral disc degeneration

Bone Research
Intervertebral disc degeneration is a degenerative disease where inflammation and immune responses play significant roles. Macrophages, as key immune cells, critically regulate inflammation through polarization into different phenotypes. In recent years,
Yiming Dou, Yiming Zhang, Yang Liu, Xun Sun, Xinyu Liu, Bin Li, Qiang Yang   +6 more
doaj   +1 more source

Exosomes and exosomal miRNAs: A new therapy for intervertebral disc degeneration

Frontiers in Pharmacology, 2022
Low back pain has been found as a major cause of global disease burden and disability. Intervertebral disc degeneration is recognized as the vital factor causing low back pain.
Zhichao Li, Yan Wu, Guoqing Tan, Zhanwang Xu, Haipeng Xue, Haipeng Xue   +5 more
doaj   +1 more source

Strategic Design of Soft Actuators in Translational Medical Robotics for Human‐Centered Healthcare

Advanced Robotics Research, EarlyView.
Soft robotics enables biocompatible, compliant medical devices, but clinical translation requires design‐driven engineering beyond materials. This perspective reviews implantable, surgical, and wearable systems by actuation mechanism, highlighting how optimized architectures and integration improve mechanical interfacing, adaptability, and durability ...
Ho Jun Jin, Jimin Kim, Inho Kim, Bong Hoon Kim   +3 more
wiley   +1 more source

Neuroregulatory Biomaterials for Intervertebral Disc Regeneration via Neuro-Disc Microenvironment Modulation

Research
Intervertebral discs have long been considered to lack neural innervation. However, recent studies have revealed that intervertebral disc degeneration is accompanied by marked pathological nerve invasion.
Ang Li, Xiaohu Li, Yi Yu, Liang Chen, Juan Wang, Wenguo Cui, Xiaodong Liu   +6 more
doaj   +1 more source