Results 11 to 20 of about 413,430 (258)

Role of macrophage in intervertebral disc degeneration

Bone Research
Intervertebral disc degeneration is a degenerative disease where inflammation and immune responses play significant roles. Macrophages, as key immune cells, critically regulate inflammation through polarization into different phenotypes. In recent years,
Yiming Dou, Yiming Zhang, Yang Liu, Xun Sun, Xinyu Liu, Bin Li, Qiang Yang   +6 more
doaj   +4 more sources

Notochord Cells in Intervertebral Disc Development and Degeneration

Journal of Developmental Biology, 2016
The intervertebral disc is a complex structure responsible for flexibility, multi-axial motion, and load transmission throughout the spine. Importantly, degeneration of the intervertebral disc is thought to be an initiating factor for back pain. Due to a
Cheryle Seguin, Matthew McCann
exaly   +4 more sources

Macrophages and Intervertebral Disc Degeneration

International Journal of Molecular Sciences, 2023
The intervertebral disc (IVD) aids in motion and acts to absorb energy transmitted to the spine. With little inherent regenerative capacity, degeneration of the intervertebral disc results in intervertebral disc disease, which contributes to low back pain and significant disability in many individuals. Increasing evidence suggests that IVD degeneration
Jinsha Koroth, Erick O. Buko, Rebecca Abbott, Casey P. Johnson, Brenda M. Ogle, Laura S. Stone, Arin M. Ellingson, Elizabeth W. Bradley   +7 more
openaire   +3 more sources

Revisiting intervertebral disc degeneration: lipid metabolism disorders as overlooked contributors to complex pathology [PDF]

Frontiers in Immunology
With the global population aging, intervertebral disc degeneration (IDD), an aging-related disease, has been confirmed to be an important cause of low back pain (LBP).
Shuang Chen, Shuang Chen, Hongshan Liu, Kaizhong Wang, Kaizhong Wang, Hui Wang, Hui Wang, Anqiao Xu, Moran Suo, Moran Suo, Xin Chen, Xin Chen, Zhonghai Li, Zhonghai Li   +13 more
doaj   +2 more sources

Molecular Mechanisms of Intervertebral Disc Degeneration

Spine Surgery and Related Research, 2019
Intervertebral disc degeneration is a well-known cause of disability, the result of which includes neck and back pain with associated mobility limitations. The purpose of this article is to provide an overview of the known molecular mechanisms through which intervertebral disc degeneration occurs as a result of complex interactions of exogenous and ...
Rider, Sean M., Mizuno, Shuichi, Kang, James D.   +2 more
openaire   +5 more sources

Computational simulation of the intervertebral disc [PDF]

, 2013
The intervertebral disc is a complex structure unlike any other in the human body. The capability to withstand high loads and deformations in six degrees of freedom is facilitated by the unique soft tissue structures. However, the mechanical behaviour of
Luxmoore, Bethany Jane
core   +6 more sources

Dual-Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration. [PDF]

Adv Sci (Weinh)
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Yan J, Lin Y, Miao S, Chao M, Dai C, Hao Z, Chen R, Guan M, Pan B, Gao F, Zhou Q.   +10 more
europepmc   +2 more sources

The biology of the ovine functional spinal unit: facet cartilage and intervertebral disc [PDF]

, 2013
Back pain will affect up to 84 % of people at some point in their lives. It is a major public health problem in Western society leading to disability and economic loss through work absence, physician visits and hospitalisation.
Gough, Caroline Shanni
core   +6 more sources

Impaired Chaperone-Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation. [PDF]

Adv Sci (Weinh)
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Chen X, Gao H, Wu W, Shi P, Chen Y, Zhang A, Cheng Z, Wu W, Yu Z, Zhang Y.   +9 more
europepmc   +2 more sources

Sal003 alleviated intervertebral disc degeneration by inhibiting apoptosis and extracellular matrix degradation through suppressing endoplasmic reticulum stress pathway in rats

Frontiers in Pharmacology, 2023
Apoptosis and extracellular matrix degradation of the nucleus pulposus are the main initiators of intervertebral disc degeneration (IVDD) and can be explained by endoplasmic reticulum (ER) stress.
Yan Chen, Yan Chen, Baixing Li, Baixing Li, Yue Xu, Tangjun Zhou, Tangjun Zhou, Changqing Zhao, Changqing Zhao, Jie Zhao, Jie Zhao   +10 more
doaj   +1 more source