Results 11 to 20 of about 23,413 (232)
Macrophages and Intervertebral Disc Degeneration
International Journal of Molecular Sciences, 2023 The intervertebral disc (IVD) aids in motion and acts to absorb energy transmitted to the spine. With little inherent regenerative capacity, degeneration of the intervertebral disc results in intervertebral disc disease, which contributes to low back pain and significant disability in many individuals. Increasing evidence suggests that IVD degeneration
Jinsha Koroth +7 more
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Genetic Therapy for Intervertebral Disc Degeneration [PDF]
International Journal of Molecular Sciences, 2021 Intervertebral disc (IVD) degeneration can cause chronic lower back pain (LBP), leading to disability. Despite significant advances in the treatment of discogenic LBP, the limitations of current treatments have sparked interest in biological approaches, including growth factor and stem cell injection, as new treatment options for patients with chronic ...
Eun Roh +7 more
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Identification of Key Modules and Hub Genes of Annulus Fibrosus in Intervertebral Disc Degeneration
Frontiers in Genetics, 2021 Background: Intervertebral disc degeneration impairs the quality of patients lives. Even though there has been development of many therapeutic strategies, most of them remain unsatisfactory due to the limited understanding of the mechanisms that underlie
Hantao Wang +5 more
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陆军军医大学学报, 2023 Objective To explore the role and possible mechanism of lysyl oxidase (LOX) in age-related degeneration of intervertebral disc. Methods Six SD rats, aged of 2, 8 and 20 months respectively, were subjected, and then underwent intervertebral disc MRI and X-
LI Jianmin +3 more
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Exosomes and exosomal miRNAs: A new therapy for intervertebral disc degeneration
Frontiers in Pharmacology, 2022 Low back pain has been found as a major cause of global disease burden and disability. Intervertebral disc degeneration is recognized as the vital factor causing low back pain.
Zhichao Li +5 more
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Frontiers in Bioengineering and Biotechnology, 2022 Intervertebral disc (IVD) degeneration (IDD) is the most universal pathogenesis of low back pain (LBP), a prevalent and costly medical problem across the world.
Zongtai Liu, Changfeng Fu
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Prague Medical Report, 2022 Intervertebral disc degeneration is a pathological condition associated with the intervertebral disc and is related to functional alterations in the human body.
Nicole Barbosa Bettiol +9 more
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Molecular Pain, 2020 Background Recent studies have found that microRNAs (miRNAs) play a critical role in development and progression of intervertebral disc degeneration. In the present study, we examined the role of miR-185 in nucleus pulposus cell behavior in vitro and the
Zhennan Yun +5 more
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Degeneration of the intervertebral disc.
Arthritis research & therapy, 2003 The intervertebral disc is a cartilaginous structure that resembles articular cartilage in its biochemistry, but morphologically it is clearly different. It shows degenerative and ageing changes earlier than does any other connective tissue in the body.
Urban, J, Roberts, S
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Effect of sIL-13Rα2-Fc on the progression of rat tail intervertebral disc degeneration
Journal of Orthopaedic Surgery and Research, 2019 Background The incidence of degenerative disc disease caused by intervertebral disc injury is increasing annually, seriously affecting the quality of life of patients and increasing the disease burden on society.
Xin Wang +7 more
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