Results 1 to 10 of about 447,723 (163)
Systemic blood plasma CCL5 and CXCL6: Potential biomarkers for human lumbar disc degeneration [PDF]
European Cells & Materials, 2016 Lumbar disc degeneration severity on magnetic resonance imaging (MRI) is associated with low back pain. Pro-inflammatory chemokines CCL5 and CXCL6 are released by induced degenerative discs, and CCL5 has been associated with discogenic back pain.
S Grad +6 more
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Paraspinal muscle degeneration and regenerative potential in a Murine model of Lumbar Disc Injury
North American Spine Society Journal, 2021 Background Context: The association between low back pain and lumbar disc degeneration is not fully characterized. One potentially overlooked factor of this process is the lumbar multifidus, which plays a role in segmental stabilization and locomotion ...
Michael R. Davies +9 more
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CRISPR-Cas9-mediated loss of function of β-catenin attenuates intervertebral disc degeneration
Molecular Therapy: Nucleic Acids, 2022 Intervertebral disc degeneration is a very common medical condition causing pain and disability, and it cannot be reversed by available treatment options.
Yunshan Fan +4 more
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Journal of Translational Medicine, 2020 Background Lipid abnormality and obesity have been proposed to be associated with lumbar disc degeneration, but little is known about the effect of ‘lipid healthy but obese’ (LH-O) and ‘lipid abnormal but not obese’ (LA-NO) phenotypes on lumbar disc ...
Sheng Shi +6 more
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Lumbar intervertebral disc degeneration in collegiate rowers
Journal of Physical Fitness and Sports Medicine, 2014 The aim of this study was to clarify the prevalence and distribution of disc degeneration in collegiate rowers and investigate the relationship between disc degeneration progression and low back pain (LBP).
Chie Sekine +6 more
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Frontiers in Pharmacology, 2023 Apoptosis and extracellular matrix degradation of the nucleus pulposus are the main initiators of intervertebral disc degeneration (IVDD) and can be explained by endoplasmic reticulum (ER) stress.
Yan Chen +10 more
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Protective role of the alpha-1-antitrypsin in intervertebral disc degeneration
Journal of Orthopaedic Surgery and Research, 2021 Background Intervertebral disc degeneration is a complex disease with high prevalence. It suggests that cell death, senescence, and extracellular matrix degradation are involved in the pathogenesis. Alpha-1 antitrypsin (AAT), a serine protease inhibitor,
Weikun Liu, Yanfu Wang
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Annals of Saudi Medicine, 2021 BACKGROUND: Lumbar disc herniation (LDH) occurs owing to the inability of the posterior longitudinal ligament (PLL) to preserve the disc material within the intervertebral space.
Asuman Kilitci +4 more
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Fexofenadine Protects Against Intervertebral Disc Degeneration Through TNF Signaling
Frontiers in Cell and Developmental Biology, 2021 Objective: Fexofenadine (FFD) is an antihistamine drug with an anti-inflammatory effect. The intervertebral disc (IVD) degeneration process is involved in inflammation in which tumor necrosis factor-α (TNF-α) plays an important role.
Kaiwen Liu +10 more
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Global Spine Journal, 2016 Introduction Experimental studies have demonstrated accelerated disc degeneration after various intradiscal procedures. However, there are only a few long-term follow-up studies using MRI images to confirm the progressive disc degeneration after ...
Jung-Woo Hur +3 more
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