Role of macrophage in intervertebral disc degeneration
Bone ResearchIntervertebral disc degeneration is a degenerative disease where inflammation and immune responses play significant roles. Macrophages, as key immune cells, critically regulate inflammation through polarization into different phenotypes. In recent years,
Yiming Dou +6 more
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Do We Need Biomarkers for Disc Degeneration?
Biomarker Insights, 2006 Disc degeneration plays a major role in this country's medical, social and economic structure. The life-time prevalence of low back pain, which has disc degeneration as its cause, is about 80% in the general population.
Helen E. Gruber, Edward N. Hanley, Jr.
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Computational simulation of the intervertebral disc [PDF]
, 2013 The intervertebral disc is a complex structure unlike any other in the human body. The capability to withstand high loads and deformations in six degrees of freedom is facilitated by the unique soft tissue structures. However, the mechanical behaviour of
Luxmoore, Bethany Jane
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The biology of the ovine functional spinal unit: facet cartilage and intervertebral disc [PDF]
, 2013 Back pain will affect up to 84 % of people at some point in their lives. It is a major public health problem in Western society leading to disability and economic loss through work absence, physician visits and hospitalisation.
Gough, Caroline Shanni
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Experimental intervertebral disc degeneration models [PDF]
, 2023 Intervertebral disc degeneration is a major health problem of close concern to both young and old. The problem is also growing as the global population ages.
Sönmez, Osman Fikret +1 more
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Intervertebral disc degeneration in dogs [PDF]
, 2010 Back pain is common in both dogs and humans, and is often associated with intervertebral disc (IVD) degeneration. The IVDs are essential structures of the spine and degeneration can ultimately result in diseases such as IVD herniation or spinal ...
Bergknut, Niklas
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Thickness of the ligamentum flavum of the spine and its relationship with disc degeneration
Coluna/Columna, 2014 Objective: This study investigates whether the thickening of the ligamentum flavum (LF) is correlated with disc degeneration. Methods: This retrospective study was conducted with 98 patients with chronic low back pain treated in a spinal surgery service ...
Thiago Mattar +4 more
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Lifestyle factors and lumbar disc disease: results of a German multi-center case-control study (EPILIFT) [PDF]
, 2010 Introduction: In the large-scale case-control study EPILIFT, we investigated the dose-response relationship between lifestyle factors (weight, smoking amount, cumulative duration of different sports activities) and lumbar disc disease.
Grifka, Joachim +21 more
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Association of abdominal obesity with lumbar disc degeneration--a magnetic resonance imaging study.
PLoS ONE, 2013 PurposeTo evaluate whether midsagittal (abdominal) obesity in magnetic resonance imaging (MRI), waist circumference (WC) and body fat percentage are associated with lumbar disc degeneration in early adulthood.MethodsWe obtained the lumbar MRI (1.5-T ...
Jani Takatalo +10 more
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Cumulative occupational lumbar load and lumbar disc disease : results of a German multi-center case-control study (EPILIFT) [PDF]
, 2009 Background The to date evidence for a dose-response relationship between physical workload and the development of lumbar disc diseases is limited. We therefore investigated the possible etiologic relevance of cumulative occupational lumbar load to lumbar
Grifka, Joachim +46 more
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