Results 31 to 40 of about 447,723 (163)

Implication of microglia activation and CSF1/CSF1R pathway in lumbar disc degeneration-related back pain

Molecular Pain, 2018
Back pain is common and costly. Although lumbar disc degeneration has long been regarded as a major contributor to back pain, how disc degeneration leads to back pain remains unclear.
Ge Yang, Lunhao Chen, Zhihua Gao, Yue Wang   +3 more
doaj   +1 more source

Principal component and factor analysis to study variations in the aging lumbar spine [PDF]

, 2015
Human spine is a multifunctional structure of human body consisting of bones, joints, ligaments and muscles which all undergo a process of change with the age. A sudden change in these features either naturally or thorough injury can lead to some serious
Shah, Akeel A., Khan, Atif A., Hutchinson, Charles E., Iliescu, Daciana, Sneath, R. J. S.   +4 more
core   +1 more source

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Single-Cell Microgel Encapsulation Improves the Therapeutic Efficacy of Mesenchymal Stem Cells in Treating Intervertebral Disc Degeneration via Inhibiting Pyroptosis

Research
While mesenchymal stem cell (MSC) shows great potentials in treating intervertebral disc degeneration, most MSC die soon after intradiscal transplantation, resulting in inferior therapeutic efficacy.
Guanrui Huang, Haotian Shen, Kaiwang Xu, Yifan Shen, Jiale Jin, Guangyu Chu, Hongyuan Xing, Zhiyun Feng, Yue Wang   +8 more
doaj   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

A comparison of interferential current efficacy in elderly intervertebral disc degeneration patients with or without sarcopenia: a retrospective study

BMC Musculoskeletal Disorders
Background Intervertebral disc degeneration and sarcopenia are both age-related diseases without effective treatments. Their comorbidities may worsen the prognosis, and further studies on interaction and therapy are needed.
Hui Yuan, Lini Dong, Ou Zhang, Xiaoxiao Wang, Zejun Chen, Yunchao Li, Haoyu He, Guohua Lü, Jing Li, Lei Kuang   +9 more
doaj   +1 more source

A New Porcine Animal Model of Cervical Disc Degeneration

Global Spine Journal, 2014
Introduction Previous in vivo animal model for disc degeneration was predominantly smaller animals. But such small discs were inappropriate to investigate the cell transplantation therapy highlighted recently.
S. E. Lee, T. A. Jahng
doaj   +1 more source

Disc degeneration promotes regional inhomogeneity in the trabecular morphology of loaded rat tail vertebrae

Journal of Orthopaedic Translation, 2018
Summary: Background: There is a close relationship between the vertebral trabecular morphology and the condition of the associated disc. Objective: The relationship between disc degeneration and vertebral trabecular inhomogeneity is unclear.
Li Ni, Linlin Zhang, Wei Xia, Guangdong Chen, Xudong Cui, Wen Zhang, Zongping Luo, Huilin Yang   +7 more
doaj   +1 more source

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay, Cassandre Landes‐Château, Lydiane Mondot, Mikael Cohen, Margherita Popolo, Jérôme de Seze, Bertrand Bourre, Françoise Durand‐Dubief, Olivier Casez, Orhun H. Kantarci, Aksel Siva, Stephanie Baillif, Darin T. Okuda, Letizia Leocani   +13 more
wiley   +1 more source

Allogeneic fibroblasts ameliorate intervertebral disc degeneration by reducing osteophytes in rabbits

Frontiers in Medicine
IntroductionLow back pain (LBP) was commonly induced by intervertebral disc degeneration (IVDD), which is accompanied by the loss of disc height and osteophyte generation.
Chen Chen, Yizhuo Huang, Lei Shi, Li Zhou, Shenao Zhou, Shenao Zhou, Hongjin Wan, Xiao Yang, Jie Zhao   +8 more
doaj   +1 more source