Results 41 to 50 of about 447,723 (163)

VEGF vascularization pathway in human intervertebral disc does not change during the disc degeneration process

BMC Research Notes, 2018
Objective During degeneration of the intervertebral disc ingrowth of blood vessels and nerves into the disc are associated with back pain. Vascular endothelial growth factors promote vasculogenesis by binding to the membrane vascular endothelial growth ...
Simona Capossela, Alessandro Bertolo, Kapila Gunasekera, Tobias Pötzel, Martin Baur, Jivko V. Stoyanov   +5 more
doaj   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Macrophages and Intervertebral Disc Degeneration

, 2023
The intervertebral disc (IVD) aids in motion and acts to absorb energy transmitted to the spine. With little inherent regenerative capacity, degeneration of the intervertebral disc results in intervertebral disc disease, which contributes to low back ...
Abbott, Rebecca, Casey P. Johnson, Koroth, Jinsha, Ogle, Brenda M., Bradley, Elizabeth W., Buko, Erick O., Jinsha Koroth, Brenda M. Ogle, Rebecca Abbott, Ellingson, Arin M., Erick O. Buko, Arin M. Ellingson, Stone, Laura S., Laura S. Stone, Elizabeth W. Bradley, Johnson, Casey P.   +15 more
core   +1 more source

Integration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether integration of serum neurofilament light chain (NfL) and cortical dysfunction improves diagnostic accuracy in amyotrophic lateral sclerosis (ALS) when applied alongside the Gold Coast criteria (GCC). Methods In this prospective study, 148 participants with suspected ALS were recruited (101 ALS and 47 with ALS ...
Aicee Dawn Calma, Nathan Pavey, Yukiko Tsuji, Amirul Ab Ghapar, Mehdi A.J. van den Bos, Bronwen Orden, Grace Lee, Linda Mekhael, Julie Ryder, Cláudia Santos Silva, David McDonald, Fakhria Kakar, Con Yiannikas, Matthew C. Kiernan, David A. Brown, Parvathi Menon, Steve Vucic   +16 more
wiley   +1 more source

Imaging observation of intervertebral disc degeneration in patients with old thoracolumbar fracture-related kyphotic deformity

Scientific Reports
Old thoracolumbar fracture with kyphosis (OTLFK) often results in low back pain, with intervertebral disc degeneration being a significant contributor.
Xi-long Cui, Ao Ding, Wen Yin, Wan-mei Yang, Wei Zhang, Hao Wu, Ji-shi Jiang, Yun-lei Zhai, Zi-kai Hua, Hai-yang Yu   +9 more
doaj   +1 more source

The preoperative predictors for subsequent degeneration in L5-S1 disc after long fusion arthrodesis terminating at L5 in patients with adult scoliosis: focus on spinopelvic parameters

Journal of Orthopaedic Surgery and Research, 2018
Background The subsequent L5-S1 disc degeneration associated with long fusion arthrodesis terminating at L5 in patients with adult scoliosis has been a common concern.
Changzhi Yan, Xianda Gao, Yadong Sun, Zhen Dong, Yong Shen   +4 more
doaj   +1 more source

The Multiple Sclerosis Severity Allele rs10191329A and Cognitive Function: A UK Biobank Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The genome‐wide association study of Multiple Sclerosis severity linked the genetic variant rs10191329A to long‐term disability and implicated brain resilience as a determinant of outcome. We hypothesised that rs10191329A might influence cognition in other neurological diseases and healthy controls.
Ioanna Zimianiti, Sheena Waters, Adil Harroud, Pernilla Stridh, Ruth Dobson, Benjamin M. Jacobs   +5 more
wiley   +1 more source

Countering Spinal Disc Degeneration [PDF]

, 2022
The pain caused by spinal disc degeneration affects millions of people worldwide and, too often, causes disability and opioid addiction. Current therapies for degenerative disc disease address only symptomatic relief.

core   +1 more source

Lumbar Degenerative Disc Disease: Current and Future Concepts of Diagnosis and Management

Advances in Orthopedics, 2012
Low back pain as a result of degenerative disc disease imparts a large socioeconomic impact on the health care system. Traditional concepts for treatment of lumbar disc degeneration have aimed at symptomatic relief by limiting motion in the lumbar spine,
Fadi Taher, David Essig, Darren R. Lebl, Alexander P. Hughes, Andrew A. Sama, Frank P. Cammisa, Federico P. Girardi   +6 more
doaj   +1 more source

Factors Associated with the Symptoms of Young Adults with L5 Spondylolysis [PDF]

Asian Spine Journal, 2018
Study Design A retrospective cohort study. Purpose To investigate the factors affecting symptoms in young adults with L5 spondylolysis. Overview of Literature L5 spondylolysis is a common disease. However, not all patients diagnosed with L5 spondylolysis
Min-Woo Kim, Kyu Yeol Lee, Seunghyun Lee
doaj   +1 more source