Results 61 to 70 of about 118,573 (345)

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

A comparison of interferential current efficacy in elderly intervertebral disc degeneration patients with or without sarcopenia: a retrospective study

BMC Musculoskeletal Disorders
Background Intervertebral disc degeneration and sarcopenia are both age-related diseases without effective treatments. Their comorbidities may worsen the prognosis, and further studies on interaction and therapy are needed.
Hui Yuan, Lini Dong, Ou Zhang, Xiaoxiao Wang, Zejun Chen, Yunchao Li, Haoyu He, Guohua Lü, Jing Li, Lei Kuang   +9 more
doaj   +1 more source

Single-Cell Microgel Encapsulation Improves the Therapeutic Efficacy of Mesenchymal Stem Cells in Treating Intervertebral Disc Degeneration via Inhibiting Pyroptosis

Research
While mesenchymal stem cell (MSC) shows great potentials in treating intervertebral disc degeneration, most MSC die soon after intradiscal transplantation, resulting in inferior therapeutic efficacy.
Guanrui Huang, Haotian Shen, Kaiwang Xu, Yifan Shen, Jiale Jin, Guangyu Chu, Hongyuan Xing, Zhiyun Feng, Yue Wang   +8 more
doaj   +1 more source

A New Porcine Animal Model of Cervical Disc Degeneration

Global Spine Journal, 2014
Introduction Previous in vivo animal model for disc degeneration was predominantly smaller animals. But such small discs were inappropriate to investigate the cell transplantation therapy highlighted recently.
S. E. Lee, T. A. Jahng
doaj   +1 more source

Disc degeneration promotes regional inhomogeneity in the trabecular morphology of loaded rat tail vertebrae

Journal of Orthopaedic Translation, 2018
Summary: Background: There is a close relationship between the vertebral trabecular morphology and the condition of the associated disc. Objective: The relationship between disc degeneration and vertebral trabecular inhomogeneity is unclear.
Li Ni, Linlin Zhang, Wei Xia, Guangdong Chen, Xudong Cui, Wen Zhang, Zongping Luo, Huilin Yang   +7 more
doaj   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

Allogeneic fibroblasts ameliorate intervertebral disc degeneration by reducing osteophytes in rabbits

Frontiers in Medicine
IntroductionLow back pain (LBP) was commonly induced by intervertebral disc degeneration (IVDD), which is accompanied by the loss of disc height and osteophyte generation.
Chen Chen, Yizhuo Huang, Lei Shi, Li Zhou, Shenao Zhou, Shenao Zhou, Hongjin Wan, Xiao Yang, Jie Zhao   +8 more
doaj   +1 more source

VEGF vascularization pathway in human intervertebral disc does not change during the disc degeneration process

BMC Research Notes, 2018
Objective During degeneration of the intervertebral disc ingrowth of blood vessels and nerves into the disc are associated with back pain. Vascular endothelial growth factors promote vasculogenesis by binding to the membrane vascular endothelial growth ...
Simona Capossela, Alessandro Bertolo, Kapila Gunasekera, Tobias Pötzel, Martin Baur, Jivko V. Stoyanov   +5 more
doaj   +1 more source

Factors Associated with the Symptoms of Young Adults with L5 Spondylolysis [PDF]

Asian Spine Journal, 2018
Study Design A retrospective cohort study. Purpose To investigate the factors affecting symptoms in young adults with L5 spondylolysis. Overview of Literature L5 spondylolysis is a common disease. However, not all patients diagnosed with L5 spondylolysis
Min-Woo Kim, Kyu Yeol Lee, Seunghyun Lee
doaj   +1 more source

Combined aorto-iliac and anterior lumbar spine reconstruction: A case series [PDF]

, 2018
Background: Treatment options for aortic-iliac pathology may include endovascular repair and open surgical repair. Treatment options for degenerative disc disease (DDD) are varied but commonly include anterior reconstruction.
Furness, James, Grosser, David, Hing, Wayne A, McEntee, Laurence, Schram, Ben, Scott-Young, Matthew, Zotti, Mario   +6 more
core   +1 more source