Results 81 to 90 of about 118,573 (345)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Biological treatment strategies for disc degeneration: potentials and shortcomings [PDF]

, 2018
Recent advances in molecular biology, cell biology and material sciences have opened a new emerging field of techniques for the treatment of musculoskeletal disorders.
Boos, Norbert, Nerlich, Andreas, Paesold, Günther   +2 more
core  

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Current strategies for treatment of intervertebral disc degeneration: substitution and regeneration possibilities [PDF]

, 2017
Background: Intervertebral disc degeneration has an annual worldwide socioeconomic impact masked as low back pain of over 70 billion euros. This disease has a high prevalence over the working age class, which raises the socioeconomic impact over the ...
A Joshi, A LA Binch, a S Htay, A Schmocker, A Thorvaldsson, AA Marino, AA Thorpe, AT Reza, AT Reza, ATH Choy, ATH Choy, B Gantenbein-Ritter, B Xu, B Xu, BH Wang, BI Woods, BJC Freeman, BP Chan, C Zhu, C-Q Zhao, CC Guterl, CC Guterl, CL Le Maitre, D Denning, D Puppi, D Purmessur, D Périé, DDN Sun, DF Coutinho, DJ Aguiar, DR Pereira, E Alsberg, EA Growney Kalaf, EH Cassinelli, ES Place, F Wang, G Chang, G Crevensten, G Feng, G Khang, G Pattappa, G Vadalà, GR Buttermann, H Cheng, H Tao, H-J Wilke, HA Lin, J Berger, J Naresh-Babu, J Silva-Correia, J Silva-Correia, J Silva-Correia, J Silva-Correia, J Silva-Correia, J Zhu, JC Iatridis, JD Thomas, JF DeLucca, JF Mano, JL Bron, JM Lee, JP Jarman, JP Thompson, JPG Urban, JS Temenoff, JT Martin, JT Martin, JT Oliveira, JT Oliveira, JWS Hayami, K Rezwan, K Takahashi, K-W Kim, KD Hudson, KL Spiller, L Calderon, L Jiang, L Koepsell, L Saad, L Xin, LA Nasto, LJ Suggs, LM Benneker, LM Boyd, M Endres, M Likhitpanichkul, M Sato, M Yasen, MB Coventry, MC Cornejo, MS Gupta, MS Gupta, N Bangel-Ruland, N Wismer, P Heneghan, P Roughley, P Schexnailder, P-PA Vergroesen, PB Malafaya, PY Neo, Q Guo, R Chou, RD Abbott, RD Bowles, RG Long, S Roberts, S Roberts, S van Uden, S Varghese, S-H Park, SBG Blanquer, SCW Chan, SK Leckie, SM Mueller, SM Richardson, SM Richardson, SR Van Tomme, T Oner, T Pirvu, TK Chik, V Stroganov, WC Bae, X Tang, X Zhou, Y Tao, Y Wu, Y-C Huang, Z Fang, Z Karimi, Z Sun   +129 more
core   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

Correlations between the sagittal plane parameters of the spine and pelvis and lumbar disc degeneration

Journal of Orthopaedic Surgery and Research, 2018
Background Studies have shown that lumbar disc herniation, degenerative lumbar instability, and other degenerative lumbar spinal diseases are often secondary to disc degeneration.
Xu Wei, Li Gengwu, Chen Chao, Li Yifan, Sang Shang, Hu Ruixi, Ji Yunhan, Zhu Xiaodong, Li Zhikun   +8 more
doaj   +1 more source

Development and degeneration of the intervertebral discs

Molecular Medicine Today, 1995
The intervertebral discs undergo profound changes in structure and composition during development and aging. They also degenerate much earlier than other cartilaginous tissues, and in severe cases may lose function completely. The reasons for this early degeneration are unknown, but external factors, such as mechanical overload on the spine, or smoking,
Urban, J, Roberts, S
openaire   +2 more sources

Associations of Sleep and Shift Work With Osteoarthritis Risk

Arthritis Care &Research, EarlyView.
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships among circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000–person cohort, we evaluated associations among sleep duration, sleeplessness/insomnia, and shift
Elizabeth L. Yanik, Abigail Bridgeman, Erik D. Herzog, Vy Pham, Bradley A. Evanoff, Farshid Guilak   +5 more
wiley   +1 more source

Is Cervical Disc Degeneration a Compensatory Mechanism in Hirayama Disease? A Retrospective Case‒Control Study

Global Spine Journal
Study Design Retrospective Cohort Study. Objective This study aimed to explore the association between cervical disc degeneration and disease progression in patients with Hirayama disease, with a particular focus on changes in the cervical intervertebral
Zhaoxuan Wang MD, Jianhua Ren MD, Hengrui Chang MD, Rui Xue MD, Guzhen Liang MD, Junkai Kou MD, Xianzhong Meng MD   +6 more
doaj   +1 more source