Results 21 to 30 of about 447,723 (163)

Notochord Cells in Intervertebral Disc Development and Degeneration

Journal of Developmental Biology, 2016
The intervertebral disc is a complex structure responsible for flexibility, multi-axial motion, and load transmission throughout the spine. Importantly, degeneration of the intervertebral disc is thought to be an initiating factor for back pain. Due to a
Matthew R. McCann, Cheryle A. Séguin
doaj   +1 more source

The Relationship Between Active and Passive Exposure to Cigarette Smoke and Severe Lumbar Intervertebral Disc Degeneration According to Demographic Data

Bagcilar Medical Bulletin, 2021
Objective:To investigate the effect of current, former and passive smoking status on degeneration of lumbar intervertebral discs.Method:Three hundred and sixty patients between the ages of 20 and 70 years, who underwent lumbar spinal magnetic resonance ...
Fatma Esra Bahadır Ülger
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Intervertebral disc characterization by shear wave elastography: an in-vitro preliminary study [PDF]

, 2014
Patient-specific numerical simulation of the spine is a useful tool both in clinic and research. While geometrical personalization of the spine is no more an issue, thanks to recent technological advances, non-invasive personalization of soft tissue’s ...
VERGARI, Claudio, BONNEAU, Dominique, ROUCH, Philippe, SKALLI, Wafa, TANTER, Mickael, DUBOIS, Guillaume, GENNISSON, Jean-Luc, DUBOUSSET, Jean   +7 more
core   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

Current evidence for a modulation of low back pain by human genetic variants [PDF]

, 2009
The manifestation of chronic back pain depends on structural, psychosocial, occupational and genetic influences. Heritability estimates for back pain range from 30% to 45%. Genetic influences are caused by genes affecting intervertebral disc degeneration
Lötsch, Jörn, Irmgard Tegeder, Jörn Lötsch, Tegeder, Irmgard   +3 more
core   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Intervertebral disc degeneration instigates vertebral endplate remodeling and facet joint pathology in a large animal model

European Cells & Materials
Although the intervertebral discs are the most studied region of the spinal motion segment with respect to their degeneration and contributions to back pain, it is becoming increasingly evident that degeneration of adjacent structures including the facet
SE Gullbrand, BS Orozco, M Fainor, K Meadows, R Hilliard, M Boyes, S Mahindroo, RL Mauck, DM Elliott, TP Schaer, HE Smith   +10 more
doaj   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Improvement of Objectivity and Accuracy in Cervical Disc Degeneration Grade Assessment Using Imaging Parameters: A Cross-Sectional Retrospective Study

Global Spine Journal
Study Design A cross-sectional retrospective study. Objectives This study aims to analyze the correlation between cervical disc degeneration grade and cervical imaging parameters and improve grade assessment objectivity and accuracy under the Miyazaki ...
Xuqiang Zhan MM, Zhanwei Wang MM, Kaiwei Wang MM, Abudureyimu Abudukeremu MM, Ning Xie MD, PhD, Tao Dai MD, Jian Fan MD, Yan Yu MD, PhD   +7 more
doaj   +1 more source