Results 11 to 20 of about 21,330 (209)
Aggrecan in Cardiovascular Development and Disease [PDF]
Journal of Histochemistry & Cytochemistry, 2020 Aggrecan is a large proteoglycan that forms giant hydrated aggregates with hyaluronan in the extracellular matrix (ECM). The extraordinary resistance of these aggregates to compression explains their abundance in articular cartilage of joints where they ensure adequate load-bearing.
Christopher D, Koch +2 more
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Structure and function of aggrecan [PDF]
Cell Research, 2002 Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in the proper functioning of articular cartilage because it provides a hydrated gel structure (via its interaction with hyaluronan and link protein) that endows the cartilage with load-bearing properties.
Chris, Kiani +4 more
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Antioxidants, 2023 Atherosclerosis is a chronic inflammatory disease and a leading cause of mortality. It is characterized by arterial wall plaques that contain high levels of cholesterol and other lipids and activated leukocytes covered by a fibrous cap of extracellular ...
Yihe Wang +6 more
doaj +1 more source
Expression of aggrecan components in perineuronal nets in the mouse cerebral cortex
IBRO Reports, 2018 Specific regions of the cerebral cortex are highly plastic in an organism’s lifetime. It is thought that perineuronal nets (PNNs) regulate plasticity, but labeling for Wisteria floribunda agglutinin (WFA), which is widely used to detect PNNs, is observed
Hiroshi Ueno +9 more
doaj +1 more source
Aggrecan structure in amphibian cartilage [PDF]
Brazilian Journal of Medical and Biological Research, 2000 The structure of the large proteoglycan present in the bullfrog epiphyseal cartilage was studied by immunochemical and biochemical methods. The isolated monomer showed a polydisperse behavior on Sepharose CL2B, with a peak at Kav = 0.14. Chondroitin sulfate chains were identified by HPLC analysis of the products formed by chondroitinase digestion and ...
Covizi, D.Z., Carvalho, H.F.
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Extracellular matrix fragmentation in young, healthy cartilaginous tissues [PDF]
European Cells & Materials, 2018 Although the composition and structure of cartilaginous tissues is complex, collagen II fibrils and aggrecan are the most abundant assemblies in both articular cartilage (AC) and the nucleus pulposus (NP) of the intervertebral disc (IVD).
RJ Craddock +5 more
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FEBS Open Bio, 2020 Osteoarthritis is the main cause of pain and disability in the elderly, with the most commonly affected joint being the knee. The prevalence of knee osteoarthritis (KOA) is significantly increased in postmenopausal women, although the mechanisms ...
Yaping Liu +7 more
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Variable expressivity in a family with an aggrecanopathy
Molecular Genetics & Genomic Medicine, 2022 Background Osteochondritis dissecans is a condition wherein there is a subchondral bone lesion that causes pain, inflammation, and cartilage damage. Dominant Familial Osteochondritis Dissecans is a rare and severe form of osteochondritis dissecans (OCD).
Antoine Denis +5 more
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ACAN Gene VNTR Polymorphism and Intervertebral Disc Degeneration in a Turkish Population
Haseki Tıp Bülteni, 2020 Aim:Intervertebral disc degeneration (IVDD) is caused by several genetic and environmental factors. Aggrecan is the major component of intervertebral disk matrix proteoglycan with multiple functional domains.
Tuba Öz +5 more
doaj +1 more source