Results 11 to 20 of about 36,790 (258)
Aggrecan in Cardiovascular Development and Disease [PDF]
Journal of Histochemistry & Cytochemistry, 2020 Aggrecan is a large proteoglycan that forms giant hydrated aggregates with hyaluronan in the extracellular matrix (ECM). The extraordinary resistance of these aggregates to compression explains their abundance in articular cartilage of joints where they ensure adequate load-bearing.
Christopher D, Koch +2 more
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Frontiers in Bioengineering and Biotechnology, 2023 Aggrecan (ACAN) is localized in the intervertebral disc (IVD) in unique compartment-specific patterns where it contributes to the tissue structure and mechanical function together with collagens.
Marta Empere +13 more
doaj +1 more source
Structure and function of aggrecan [PDF]
Cell Research, 2002 Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in the proper functioning of articular cartilage because it provides a hydrated gel structure (via its interaction with hyaluronan and link protein) that endows the cartilage with load-bearing properties.
Chris, Kiani +4 more
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Bone & Joint Research, 2023 Aims: This study was performed to explore the effect of melatonin on pyroptosis in nucleus pulposus cells (NPCs) and the underlying mechanism of that effect.
Zhibiao Bai +5 more
doaj +1 more source
Antioxidants, 2023 Atherosclerosis is a chronic inflammatory disease and a leading cause of mortality. It is characterized by arterial wall plaques that contain high levels of cholesterol and other lipids and activated leukocytes covered by a fibrous cap of extracellular ...
Yihe Wang +6 more
doaj +1 more source
Expression of aggrecan components in perineuronal nets in the mouse cerebral cortex
IBRO Reports, 2018 Specific regions of the cerebral cortex are highly plastic in an organism’s lifetime. It is thought that perineuronal nets (PNNs) regulate plasticity, but labeling for Wisteria floribunda agglutinin (WFA), which is widely used to detect PNNs, is observed
Hiroshi Ueno +9 more
doaj +1 more source
The role of proteases in pathologies of the synovial joint [PDF]
, 2008 Synovial (diarthrodial) joints are employed within the body to provide skeletal mobility and have a characteristic structure adapted to provide a smooth almost frictionless surface for articulation.
Buttle, D, Jones, GC, Riley, GP
core +1 more source
Aggrecan structure in amphibian cartilage [PDF]
Brazilian Journal of Medical and Biological Research, 2000 The structure of the large proteoglycan present in the bullfrog epiphyseal cartilage was studied by immunochemical and biochemical methods. The isolated monomer showed a polydisperse behavior on Sepharose CL2B, with a peak at Kav = 0.14. Chondroitin sulfate chains were identified by HPLC analysis of the products formed by chondroitinase digestion and ...
Covizi, D.Z., Carvalho, H.F.
openaire +5 more sources
Low Density Lipoprotein Receptor-related Protein 1 (LRP1)-mediated Endocytic Clearance of a Disintegrin and Metalloproteinase with Thrombospondin Motifs-4 (ADAMTS-4) FUNCTIONAL DIFFERENCES OF NON-CATALYTIC DOMAINS OF ADAMTS-4 AND ADAMTS-5 IN LRP1 BINDING [PDF]
, 2014 Degradation of the cartilage proteoglycan aggrecan is an early event in the development of osteoarthritis, and a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4) and ADAMTS-5 are considered to be the major aggrecan-degrading ...
Dudhia, J +7 more
core +2 more sources