Results 11 to 20 of about 27,782 (234)
Lateral Nanomechanics of Cartilage Aggrecan Macromolecules [PDF]
Biophysical Journal, 2007 To explore the role of the brush-like proteoglycan, aggrecan, in the shear behavior of cartilage tissue, we measured the lateral resistance to deformation of a monolayer of chemically end-attached cartilage aggrecan on a microcontact printed surface in aqueous NaCl solutions via lateral force microscopy.
Han, Lin +3 more
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Aggrecan degradation in osteoarthritis and rheumatoid arthritis
Acta Orthopaedica Scandinavica, 1995 Aggrecan turnover is critically important to maintain extracellular matrix homeostasis in articular cartilage. Cartilage aggrecan metabolism has been studied in chondrocyte cell cultures, cartilage explant cultures, and in whole animal models. In many of these studies, matrix metalloproteinases (MMPs) are proposed to degrade cartilage aggrecan.
M W, Lark, E K, Bayne, L S, Lohmander
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Gel-like behavior in aggrecan assemblies [PDF]
The Journal of Chemical Physics, 2008 Aggrecan, a large biological polyelectrolyte molecule with a bottlebrush shape, forms complexes with hyaluronic acid (HA) that provide compressive resistance in cartilage. In solutions of aggrecan alone, the concentration dependence of the osmotic pressure Π is marked by self-assembly of the molecules into aggregates.
Horkay, Ferenc +3 more
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Aggrecan modulation of growth plate morphogenesis [PDF]
Developmental Biology, 2009 Chick and mouse embryos with heritable deficiencies of aggrecan exhibit severe dwarfism and premature death, demonstrating the essential involvement of aggrecan in development. The aggrecan-deficient nanomelic (nm) chick mutant E12 fully formed growth plate (GP) is devoid of matrix and exhibits markedly altered cytoarchitecture, proliferative capacity,
Domowicz, Miriam S. +3 more
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Probing nanomechanics of aggrecan and the aggrecan-rich pericellular matrix of chondrocytes in cartilage [PDF]
, 2005 The mechanical properties of articular cartilage are associated with the extracellular matrix network of type II collagen and the proteoglycan, aggrecan, which in combination provide the tensile, shear, and compressive stiffness of the tissue. While the collagen network mainly provides resistance to tensile and shear deformation, aggrecan enmeshed ...
Ng, Laurel Jean
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Structure and function of aggrecan [PDF]
Cell Research, 2002 Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in the proper functioning of articular cartilage because it provides a hydrated gel structure (via its interaction with hyaluronan and link protein) that endows the cartilage with load-bearing properties.
Chris, Kiani +4 more
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Aggrecan in Cardiovascular Development and Disease [PDF]
Journal of Histochemistry & Cytochemistry, 2020 Aggrecan is a large proteoglycan that forms giant hydrated aggregates with hyaluronan in the extracellular matrix (ECM). The extraordinary resistance of these aggregates to compression explains their abundance in articular cartilage of joints where they ensure adequate load-bearing.
Christopher D, Koch +2 more
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Neonatal Sevoflurane Exposure Induces Long-Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2. [PDF]
Adv Sci (Weinh)Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Liang L +11 more
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Extracellular matrix fragmentation in young, healthy cartilaginous tissues [PDF]
European Cells & Materials, 2018 Although the composition and structure of cartilaginous tissues is complex, collagen II fibrils and aggrecan are the most abundant assemblies in both articular cartilage (AC) and the nucleus pulposus (NP) of the intervertebral disc (IVD).
RJ Craddock +5 more
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Aggrecan structure in amphibian cartilage [PDF]
Brazilian Journal of Medical and Biological Research, 2000 The structure of the large proteoglycan present in the bullfrog epiphyseal cartilage was studied by immunochemical and biochemical methods. The isolated monomer showed a polydisperse behavior on Sepharose CL2B, with a peak at Kav = 0.14. Chondroitin sulfate chains were identified by HPLC analysis of the products formed by chondroitinase digestion and ...
Covizi, D.Z., Carvalho, H.F.
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