Frontiers in Integrative Neuroscience, 2018 Aggrecan, a chondroitin sulfate (CS) proteoglycan, forms lattice-like extracellular matrix structures called perineuronal nets (PNNs). Neocortical PNNs primarily ensheath parvalbumin-expressing inhibitory neurons (parvalbumin, PV cells) late in brain ...
Shinji Miyata +3 more
doaj +1 more source
CELLULAR AND MOLECULAR ACTIVITY OF A STANDARDIZED SMALL SEA FISH EXTRACT IN AN EXPERIMENTAL MODEL OF PRIMARY HUMAN CARTILAGE CELLS [PDF]
Romanian Journal of Rheumatology, 2018 The inflammatory, degenerative and rheumatic diseases are triggered and evolving at osteoarticular level due to the disruption of functionality of constitutive cells and extracellular microenvironment correlated with systemic responses as synthesis of ...
Emilia Buse +5 more
doaj +1 more source
Post-traumatic osteoarthritis in mice following mechanical injury to the synovial joint [PDF]
, 2017 We investigated the spectrum of lesions characteristic of post-traumatic osteoarthritis (PTOA) across the knee joint in response to mechanical injury.
Chinzei, Nobuaki +7 more
core +3 more sources
Biology, 2020 The role of proteoglycans in the central nervous system (CNS) is a rapidly evolving field and has major implications in the field of CNS injury. Chondroitin sulfate proteoglycans (CSPGs) increase in abundance following damage to the spinal cord and ...
Thomas M. Hering +3 more
doaj +1 more source
Increased expression of aggrecan and biglycan mRNA in Achilles tendinopathy [PDF]
, 2006 To determine the expression of mRNA encoding the proteoglycans aggrecan, versican, biglycan and decorin in mid-tendon samples of chronic painful Achilles tendinopathy and ruptured Achilles tendons, compared with normal tendons.
Corps, AN +5 more
core +1 more source
Neonatal Zika virus infection causes transient perineuronal net degradation
Frontiers in Cellular Neuroscience, 2023 Perineuronal nets (PNNs) form a specialized extracellular matrix that predominantly surrounds parvalbumin (PV)-expressing GABAergic inhibitory interneurons and help regulate neuronal activity. Their formation early in the postnatal period is regulated by
Kaliroi Engel +6 more
doaj +1 more source
Identification of a heterozygous ACAN mutation in a 15-year-old boy with short stature who presented with advanced bone age: a case report and review of the literature [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2020 Longitudinal bone growth is primarily mediated by the growth plate, which is a specialized cartilaginous structure. Aggrecan, encoded by ACAN, is a primary proteoglycan component of the extracellular matrix in both the growth plate and articular ...
Tae Youp Kim +4 more
doaj +1 more source
ADAM10 Localization in Temporomandibular Joint Disk with Internal Derangement: An Ex Vivo Immunohistochemical Study [PDF]
, 2016 The purpose of this study was to determine the presence of ADAM10 in temporomandibular joint disk with internal derangement. Twenty-five paraffin blocks of displaced temporomandibular joint (TMJ) disk specimens from earlier investigations were retrieved ...
Almeida, Luis Eduardo +7 more
core +2 more sources
Directing Chondrogenesis of Stem Cells with Specific Blends of Cellulose and Silk [PDF]
, 2013 Biomaterials that can stimulate stem cell differentiation without growth factor supplementation provide potent and cost-effective scaffolds for regenerative medicine.
Hollander, Anthony P +7 more
core +2 more sources
Identification of Hyaluronan-binding Domains of Aggrecan [PDF]
Journal of Biological Chemistry, 1997 Aggrecan, a large cartilage proteoglycan, interacts with hyaluronan (HA), to form aggregates which function to resist compression in joints. The N-terminal region of aggrecan contains two structurally related globular domains, G1 and G2 separated by IGD domain. The G1 domain consists of three subdomains, A, B, and B', structural features characteristic
H, Watanabe +4 more
openaire +2 more sources