Results 31 to 40 of about 27,782 (234)

Identification of a heterozygous ACAN mutation in a 15-year-old boy with short stature who presented with advanced bone age: a case report and review of the literature [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2020
Longitudinal bone growth is primarily mediated by the growth plate, which is a specialized cartilaginous structure. Aggrecan, encoded by ACAN, is a primary proteoglycan component of the extracellular matrix in both the growth plate and articular ...
Tae Youp Kim, Kyung Mi Jang, Chang Won Keum, Seung Hwan Oh, Woo Yeong Chung   +4 more
doaj   +1 more source

The involvement of aggrecan polymorphism in degeneration of human intervertebral disc and articular cartilage [PDF]

European Cells & Materials, 2006
The functions of the intervertebral disc and of articular cartilage are intimately related to their aggrecan content. Aggrecan is a proteoglycan that interacts with hyaluronan to form large aggregates, which are responsible for the ability of the tissues
P Roughley, D Martens, J Rantakokko, M Alini, F Mwale, J Antoniou   +5 more
doaj  

Addition of High Molecular Weight Hyaluronic Acid to Fibroblast-Like Stromal Cells Modulates Endogenous Hyaluronic Acid Metabolism and Enhances Proteolytic Processing and Secretion of Versican

Cells, 2020
We have examined the effect of exogenous linear chain high molecular weight hyaluronic acid (HMW HA) on endogenously synthesized hyaluronic acid (HA) and associated binding proteins in primary cultures of fibroblast-like stromal cells that were obtained ...
Jiapeng Xue, Jinnan Chen, Quan Shen, Deva Chan, Jun Li, Adam P. Tanguay, Tannin A. Schmidt, Faizan Niazi, Anna Plaas   +8 more
doaj   +1 more source

Testing if Micro-CT Is Capable of Quantitating the Extent of Proteoglycan-Aggrecan Induced Axial Spondyloarthritis in Mice

Frontiers in Immunology, 2021
ObjectiveInjections of proteoglycan aggrecan (PGA) have been reported to induce axial spondyloarthritis (ax-SpA) in BALB/c mice. It is considered to be a model for radiographic ax-SpA.
Qing Han, Qing Han, ZhaoHui Zheng, ZhaoHui Zheng, Qiang Liang, Qiang Liang, Kui Zhang, Kui Zhang, FengFan Yang, FengFan Yang, XiangHui Fu, XiangHui Fu, Xing Luo, Xing Luo, Jin Ding, Jin Ding, Ronghua Xie, Ronghua Xie, WenXiao Zhu, WenXiao Zhu, Ping Zhu, Ping Zhu   +21 more
doaj   +1 more source

The Link between Aggrecan and Familial Osteochondritis Dissecans

Surgeries, 2021
Osteochondritis dissecans (OCD) is a chronic disease of the articular cartilage characterized by focal lesions of subchondral bone and overlaying cartilage. Through the growing number of reports describing the high prevalence of OCD in some families, the
Samantha Ozere, Sami Chergui, Megan E. Cooke, Thierry Pauyo, Derek H. Rosenzweig   +4 more
doaj   +1 more source

Cartilage Aggrecan Can Undergo Self-Adhesion [PDF]

, 2008
Here it is reported that aggrecan, the highly negatively charged macromolecule in the cartilage extracellular matrix, undergoes Ca2+-mediated self-adhesion after static compression even in the presence of strong electrostatic repulsion in physiological ...
Ortiz, Christine, Dean, Delphine, Han, Lin, Daher, Laura A., Grodzinsky, Alan J.   +4 more
core   +1 more source

Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activity

Arthritis Research & Therapy, 2017
Background A hallmark of osteoarthritis is increased proteolytic cleavage of aggrecan. Cross talk between cartilage and the synovium + joint capsule (SJC) can drive cartilage degradation by activating proteases in both tissues.
Per Swärd, Yang Wang, Maria Hansson, L. Stefan Lohmander, Alan J. Grodzinsky, André Struglics   +5 more
doaj   +1 more source

The extracellular processing of aggrecan aggregate and its effect on CD44 mediated internalization of hyaluronan.

, 2023
In many cells the hyaluronan receptor CD44 mediates the endocytosis of hyaluronan and its delivery to endosomes / lysosomes. The regulation of this process remains largely unknown.
Danielson, Ben, NC DOCKS at East Carolina University   +1 more
core  

Elevated aggrecan mRNA in early murine osteoarthritis [PDF]

, 1997
SummaryMale STR/ort mice develop osteoarthritis in the tibial articular cartilage. Low grade histological lesions first appear between 10–20 weeks of age.
Bayliss, Michael T., Mason, Roger M., Gaffen, John D.   +2 more
core   +1 more source

TNFα induces Aggrecan Breakdown.

, 2015
(A) Picrosirius red & Alcian blue staining of Control and Recovery groups. Recovery involved 6 days of TNFα exposure followed by 14 days with control media.
James C. Iatridis (413611), Morakot Likhitpanichkul (697248), Benjamin A. Walter (697247), Peter J. Roughley (697249), Andrew C. Hecht (629030), Svenja Illien-Junger (413609)   +5 more
core   +1 more source