Results 21 to 30 of about 27,782 (234)

High follicle‐stimulating hormone levels accelerate cartilage damage of knee osteoarthritis in postmenopausal women through the PI3K/AKT/NF‐κB pathway

FEBS Open Bio, 2020
Osteoarthritis is the main cause of pain and disability in the elderly, with the most commonly affected joint being the knee. The prevalence of knee osteoarthritis (KOA) is significantly increased in postmenopausal women, although the mechanisms ...
Yaping Liu, Mengqi Zhang, Dehuan Kong, Yan Wang, Jian Li, Wenjuan Liu, Yilin Fu, Jin Xu   +7 more
doaj   +1 more source

Variable expressivity in a family with an aggrecanopathy

Molecular Genetics & Genomic Medicine, 2022
Background Osteochondritis dissecans is a condition wherein there is a subchondral bone lesion that causes pain, inflammation, and cartilage damage. Dominant Familial Osteochondritis Dissecans is a rare and severe form of osteochondritis dissecans (OCD).
Antoine Denis, Sami Chergui, Shuaa Basalom, Philippe M. Campeau, Chantal Janelle, Thierry Pauyo   +5 more
doaj   +1 more source

ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan [PDF]

, 2000
A disintegrin-like and metalloproteinase with thrombospondin type I motifs-1 (ADAMTS-1) is an extracellular matrix-anchored metalloproteinase. In this study we have demonstrated that ADAMTS-1 is able to cleave a major cartilage proteoglycan, aggrecan.
Nakamura, Hiroyuki, Kouji Matsushima, Masayuki Miyasaka, Kuno, Kouji, Hiroshi Ohno, Yasunori Okada, Ohno, Hiroshi, Matsushima, Kouji, Okada, Yasunori, Kawashima, Hiroto, Miyasaka, Masayuki, Kouji Kuno, Hiroyuki Nakamura, Hiroto Kawashima   +13 more
core   +1 more source

ACAN Gene VNTR Polymorphism and Intervertebral Disc Degeneration in a Turkish Population

Haseki Tıp Bülteni, 2020
Aim:Intervertebral disc degeneration (IVDD) is caused by several genetic and environmental factors. Aggrecan is the major component of intervertebral disk matrix proteoglycan with multiple functional domains.
Tuba Öz, İsmail Kaya, Ayşe Feyda Nursal, Hasan Emre Aydın, Osman Demir, Serbülent Yiğit   +5 more
doaj   +1 more source

Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway

Bone & Joint Research, 2021
Aims: Interleukin (IL)-1β is one of the major pathogenic regulators during the pathological development of intervertebral disc degeneration (IDD). However, effective treatment options for IDD are limited.
Zi-Miao Liu, Cheng-Chang Lu, Po-Chih Shen, Shih-Hsiang Chou, Chia-Lung Shih, Jian-Chih Chen, Yin Chun Tien   +6 more
doaj   +1 more source

Structural Variation of Chondroitin Sulfate Chains Contributes to the Molecular Heterogeneity of Perineuronal Nets

Frontiers in Integrative Neuroscience, 2018
Aggrecan, a chondroitin sulfate (CS) proteoglycan, forms lattice-like extracellular matrix structures called perineuronal nets (PNNs). Neocortical PNNs primarily ensheath parvalbumin-expressing inhibitory neurons (parvalbumin, PV cells) late in brain ...
Shinji Miyata, Satomi Nadanaka, Michihiro Igarashi, Hiroshi Kitagawa   +3 more
doaj   +1 more source

CELLULAR AND MOLECULAR ACTIVITY OF A STANDARDIZED SMALL SEA FISH EXTRACT IN AN EXPERIMENTAL MODEL OF PRIMARY HUMAN CARTILAGE CELLS [PDF]

Romanian Journal of Rheumatology, 2018
The inflammatory, degenerative and rheumatic diseases are triggered and evolving at osteoarticular level due to the disruption of functionality of constitutive cells and extracellular microenvironment correlated with systemic responses as synthesis of ...
Emilia Buse, Brandusa Dumitriu, Laura Olariu, Diana Ene, Mihai Bojinca, Toma Papacocea   +5 more
doaj   +1 more source

Contributions of Chondroitin Sulfate, Keratan Sulfate and N-linked Oligosaccharides to Inhibition of Neurite Outgrowth by Aggrecan

Biology, 2020
The role of proteoglycans in the central nervous system (CNS) is a rapidly evolving field and has major implications in the field of CNS injury. Chondroitin sulfate proteoglycans (CSPGs) increase in abundance following damage to the spinal cord and ...
Thomas M. Hering, Justin A. Beller, Christopher M. Calulot, Diane M. Snow   +3 more
doaj   +1 more source

Fibronectin III 13-14 Domains Induce Joint Damage via Toll-Like Receptor 4 Activation and Synergize with Interleukin-1 and Tumour Necrosis Factor [PDF]

, 2011
Cartilage loss is a feature of chronic arthritis. It results from degradation of the extracellular matrix which is composed predominantly of aggrecan and type II collagen.
Saralili Dipa Robertson, Sofat, N, Nidhi Sofat, Wait, R, Robertson, SD, Wait, Robin, Robin Wait   +6 more
core   +1 more source

Neonatal Zika virus infection causes transient perineuronal net degradation

Frontiers in Cellular Neuroscience, 2023
Perineuronal nets (PNNs) form a specialized extracellular matrix that predominantly surrounds parvalbumin (PV)-expressing GABAergic inhibitory interneurons and help regulate neuronal activity. Their formation early in the postnatal period is regulated by
Kaliroi Engel, Ha-Na Lee, Bhanu P. Tewari, Aaron P. Lewkowicz, Derek D. C. Ireland, Mohanraj Manangeeswaran, Daniela Verthelyi   +6 more
doaj   +1 more source