Results 21 to 30 of about 21,356 (208)
CELLULAR AND MOLECULAR ACTIVITY OF A STANDARDIZED SMALL SEA FISH EXTRACT IN AN EXPERIMENTAL MODEL OF PRIMARY HUMAN CARTILAGE CELLS [PDF]
Romanian Journal of Rheumatology, 2018 The inflammatory, degenerative and rheumatic diseases are triggered and evolving at osteoarticular level due to the disruption of functionality of constitutive cells and extracellular microenvironment correlated with systemic responses as synthesis of ...
Emilia Buse +5 more
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Biology, 2020 The role of proteoglycans in the central nervous system (CNS) is a rapidly evolving field and has major implications in the field of CNS injury. Chondroitin sulfate proteoglycans (CSPGs) increase in abundance following damage to the spinal cord and ...
Thomas M. Hering +3 more
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Neonatal Zika virus infection causes transient perineuronal net degradation
Frontiers in Cellular Neuroscience, 2023 Perineuronal nets (PNNs) form a specialized extracellular matrix that predominantly surrounds parvalbumin (PV)-expressing GABAergic inhibitory interneurons and help regulate neuronal activity. Their formation early in the postnatal period is regulated by
Kaliroi Engel +6 more
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Identification of a heterozygous ACAN mutation in a 15-year-old boy with short stature who presented with advanced bone age: a case report and review of the literature [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2020 Longitudinal bone growth is primarily mediated by the growth plate, which is a specialized cartilaginous structure. Aggrecan, encoded by ACAN, is a primary proteoglycan component of the extracellular matrix in both the growth plate and articular ...
Tae Youp Kim +4 more
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The involvement of aggrecan polymorphism in degeneration of human intervertebral disc and articular cartilage [PDF]
European Cells & Materials, 2006 The functions of the intervertebral disc and of articular cartilage are intimately related to their aggrecan content. Aggrecan is a proteoglycan that interacts with hyaluronan to form large aggregates, which are responsible for the ability of the tissues
P Roughley +5 more
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Cells, 2020 We have examined the effect of exogenous linear chain high molecular weight hyaluronic acid (HMW HA) on endogenously synthesized hyaluronic acid (HA) and associated binding proteins in primary cultures of fibroblast-like stromal cells that were obtained ...
Jiapeng Xue +8 more
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Frontiers in Immunology, 2021 ObjectiveInjections of proteoglycan aggrecan (PGA) have been reported to induce axial spondyloarthritis (ax-SpA) in BALB/c mice. It is considered to be a model for radiographic ax-SpA.
Qing Han +21 more
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The Link between Aggrecan and Familial Osteochondritis Dissecans
Surgeries, 2021 Osteochondritis dissecans (OCD) is a chronic disease of the articular cartilage characterized by focal lesions of subchondral bone and overlaying cartilage. Through the growing number of reports describing the high prevalence of OCD in some families, the
Samantha Ozere +4 more
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Arthritis Research & Therapy, 2017 Background A hallmark of osteoarthritis is increased proteolytic cleavage of aggrecan. Cross talk between cartilage and the synovium + joint capsule (SJC) can drive cartilage degradation by activating proteases in both tissues.
Per Swärd +5 more
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Identification of Hyaluronan-binding Domains of Aggrecan [PDF]
Journal of Biological Chemistry, 1997 Aggrecan, a large cartilage proteoglycan, interacts with hyaluronan (HA), to form aggregates which function to resist compression in joints. The N-terminal region of aggrecan contains two structurally related globular domains, G1 and G2 separated by IGD domain. The G1 domain consists of three subdomains, A, B, and B', structural features characteristic
H, Watanabe +4 more
openaire +2 more sources