Results 21 to 30 of about 21,330 (209)

Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway

Bone & Joint Research, 2021
Aims: Interleukin (IL)-1β is one of the major pathogenic regulators during the pathological development of intervertebral disc degeneration (IDD). However, effective treatment options for IDD are limited.
Zi-Miao Liu, Cheng-Chang Lu, Po-Chih Shen, Shih-Hsiang Chou, Chia-Lung Shih, Jian-Chih Chen, Yin Chun Tien   +6 more
doaj   +1 more source

Structural Variation of Chondroitin Sulfate Chains Contributes to the Molecular Heterogeneity of Perineuronal Nets

Frontiers in Integrative Neuroscience, 2018
Aggrecan, a chondroitin sulfate (CS) proteoglycan, forms lattice-like extracellular matrix structures called perineuronal nets (PNNs). Neocortical PNNs primarily ensheath parvalbumin-expressing inhibitory neurons (parvalbumin, PV cells) late in brain ...
Shinji Miyata, Satomi Nadanaka, Michihiro Igarashi, Hiroshi Kitagawa   +3 more
doaj   +1 more source

CELLULAR AND MOLECULAR ACTIVITY OF A STANDARDIZED SMALL SEA FISH EXTRACT IN AN EXPERIMENTAL MODEL OF PRIMARY HUMAN CARTILAGE CELLS [PDF]

Romanian Journal of Rheumatology, 2018
The inflammatory, degenerative and rheumatic diseases are triggered and evolving at osteoarticular level due to the disruption of functionality of constitutive cells and extracellular microenvironment correlated with systemic responses as synthesis of ...
Emilia Buse, Brandusa Dumitriu, Laura Olariu, Diana Ene, Mihai Bojinca, Toma Papacocea   +5 more
doaj   +1 more source

Contributions of Chondroitin Sulfate, Keratan Sulfate and N-linked Oligosaccharides to Inhibition of Neurite Outgrowth by Aggrecan

Biology, 2020
The role of proteoglycans in the central nervous system (CNS) is a rapidly evolving field and has major implications in the field of CNS injury. Chondroitin sulfate proteoglycans (CSPGs) increase in abundance following damage to the spinal cord and ...
Thomas M. Hering, Justin A. Beller, Christopher M. Calulot, Diane M. Snow   +3 more
doaj   +1 more source

Neonatal Zika virus infection causes transient perineuronal net degradation

Frontiers in Cellular Neuroscience, 2023
Perineuronal nets (PNNs) form a specialized extracellular matrix that predominantly surrounds parvalbumin (PV)-expressing GABAergic inhibitory interneurons and help regulate neuronal activity. Their formation early in the postnatal period is regulated by
Kaliroi Engel, Ha-Na Lee, Bhanu P. Tewari, Aaron P. Lewkowicz, Derek D. C. Ireland, Mohanraj Manangeeswaran, Daniela Verthelyi   +6 more
doaj   +1 more source

Identification of a heterozygous ACAN mutation in a 15-year-old boy with short stature who presented with advanced bone age: a case report and review of the literature [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2020
Longitudinal bone growth is primarily mediated by the growth plate, which is a specialized cartilaginous structure. Aggrecan, encoded by ACAN, is a primary proteoglycan component of the extracellular matrix in both the growth plate and articular ...
Tae Youp Kim, Kyung Mi Jang, Chang Won Keum, Seung Hwan Oh, Woo Yeong Chung   +4 more
doaj   +1 more source

The involvement of aggrecan polymorphism in degeneration of human intervertebral disc and articular cartilage [PDF]

European Cells & Materials, 2006
The functions of the intervertebral disc and of articular cartilage are intimately related to their aggrecan content. Aggrecan is a proteoglycan that interacts with hyaluronan to form large aggregates, which are responsible for the ability of the tissues
P Roughley, D Martens, J Rantakokko, M Alini, F Mwale, J Antoniou   +5 more
doaj  

Addition of High Molecular Weight Hyaluronic Acid to Fibroblast-Like Stromal Cells Modulates Endogenous Hyaluronic Acid Metabolism and Enhances Proteolytic Processing and Secretion of Versican

Cells, 2020
We have examined the effect of exogenous linear chain high molecular weight hyaluronic acid (HMW HA) on endogenously synthesized hyaluronic acid (HA) and associated binding proteins in primary cultures of fibroblast-like stromal cells that were obtained ...
Jiapeng Xue, Jinnan Chen, Quan Shen, Deva Chan, Jun Li, Adam P. Tanguay, Tannin A. Schmidt, Faizan Niazi, Anna Plaas   +8 more
doaj   +1 more source

Testing if Micro-CT Is Capable of Quantitating the Extent of Proteoglycan-Aggrecan Induced Axial Spondyloarthritis in Mice

Frontiers in Immunology, 2021
ObjectiveInjections of proteoglycan aggrecan (PGA) have been reported to induce axial spondyloarthritis (ax-SpA) in BALB/c mice. It is considered to be a model for radiographic ax-SpA.
Qing Han, Qing Han, ZhaoHui Zheng, ZhaoHui Zheng, Qiang Liang, Qiang Liang, Kui Zhang, Kui Zhang, FengFan Yang, FengFan Yang, XiangHui Fu, XiangHui Fu, Xing Luo, Xing Luo, Jin Ding, Jin Ding, Ronghua Xie, Ronghua Xie, WenXiao Zhu, WenXiao Zhu, Ping Zhu, Ping Zhu   +21 more
doaj   +1 more source

The Link between Aggrecan and Familial Osteochondritis Dissecans

Surgeries, 2021
Osteochondritis dissecans (OCD) is a chronic disease of the articular cartilage characterized by focal lesions of subchondral bone and overlaying cartilage. Through the growing number of reports describing the high prevalence of OCD in some families, the
Samantha Ozere, Sami Chergui, Megan E. Cooke, Thierry Pauyo, Derek H. Rosenzweig   +4 more
doaj   +1 more source