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Undenatured type II collagen for knee osteoarthritis [PDF]

Annals of Medicine
Introduction: Knee Osteoarthritis (OA) leads to significant pain and reduced function and affects patients’ overall quality of life (QoL). Conservative modalities are the first line of management, resorting to surgery only if they fail.
Ashim Gupta, Nicola Maffulli
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Micronutrient optimization for tissue engineered articular cartilage production of type II collagen [PDF]

Frontiers in Bioengineering and Biotechnology, 2023
Tissue Engineering of cartilage has been hampered by the inability of engineered tissue to express native levels of type II collagen in vitro. Inadequate levels of type II collagen are, in part, due to a failure to recapitulate the physiological ...
Maria A. Cruz, Yamilet Gonzalez, Javier A. Vélez Toro, Makan Karimzadeh, Anthony Rubbo, Lauren Morris, Ramapaada Medam, Taylor Splawn, Marilyn Archer, Russell J. Fernandes, James E. Dennis, Thomas J. Kean, Thomas J. Kean   +12 more
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UC-II® undenatured type II collagen data show retention during functional food and beverage prototype processing [PDF]

Data in Brief, 2023
Nowadays, collagen is widely used in food and beverage industries to enhance the nutritional and health value of the products. While many see this as an ideal way to incorporate more collagen into their diets, the exposure of these proteins to high ...
George Pates, Tyler White, Shane Durkee, Zainulabedin Saiyed   +3 more
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Efficacy and tolerability of native (undenatured) type II collagen supplementation for joint health in healthy volunteers: a randomized double-blind placebo-controlled study [PDF]

Nutrition Journal
Background In non-osteoarthritic individuals, the appearance of joint discomfort with physical activity is a potential indicator of initial joint degeneration. The present study aimed to evaluate the efficacy and tolerability of native (undenatured) type-
Ingrid Möller, Kirsten Martínez, Andrea Terradillos-Guillén, Ester Costa-Larrión, Daniel Martínez-Puig, Javier Velasco-Álvarez   +5 more
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Dynamic compression inhibits cytokine-mediated type II collagen degradation [PDF]

Osteoarthritis and Cartilage Open, 2022
Objective: To examine the effect of dynamic compressive loading applied intermittently on bovine cartilage explants stimulated with proinflammatory cytokines over 21 days. Design: Cartilage explants were cultured for 21 days with Oncostatin M and TNFα (O 
Amalie Engstrøm, Frederik S. Gillesberg, Anne-Christine Bay Jensen, Morten A. Karsdal, Christian S. Thudium   +4 more
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Efficacy and safety of native type II collagen in modulating knee osteoarthritis symptoms: a randomised, double‐blind, placebo‐controlled trial [PDF]

Journal of Experimental Orthopaedics, 2022
Purpose Knee osteoarthritis (OA) is the most common form of clinical arthritis in middle‐aged and older individuals. Undenatured or native type II (TII) collagen derived from the chicken sternum has a good therapeutic effect on relieving severe pain of ...
Cheng Luo, Weike Su, Ying Song, Shalini Srivastava   +3 more
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Management of Osteoarthritis and Joint Support Using Feed Supplements: A Scoping Review of Undenatured Type II Collagen and Boswellia serrata [PDF]

Animals, 2023
In the multimodal management of osteoarthritis (OA) in recent decades, the use of feed supplements to maintain joint cartilage has been advocated. The aim of this scoping review is to present the results found in the veterinary literature on the use of ...
Ana Zapata, Rocio Fernández-Parra
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Efficacy of combined undenatured type II collagen and hydrolysed collagen supplementation in knee osteoarthritis: a randomised controlled trial [PDF]

Scientific Reports
Collagen supplements have gained significant market popularity, with numerous products claiming to improve knee osteoarthritis symptoms. Previous clinical studies have primarily evaluated individual collagen formulations, with most being industry ...
Varah Yuenyongviwat, Chirathit Anusitviwat, Pakjai Tuntarattanapong, Theerawit Hongnaparak, Khanin Iamthanaporn   +4 more
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Bioprinting of Collagen Type I and II via Aerosol Jet Printing for the Replication of Dense Collagenous Tissues

Frontiers in Bioengineering and Biotechnology, 2021
Collagen has grown increasingly present in bioprinting, however collagen bioprinting has mostly been limited to the extrusion printing of collagen type I to form weak collagen hydrogels.
Rory Gibney, Rory Gibney, Eleonora Ferraris   +2 more
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In the quest of the optimal tissue source (porcine male and female articular, tracheal and auricular cartilage) for the development of collagen sponges for articular cartilage

Biomedical Engineering Advances, 2021
Background: In the quest of the ideal material for scaffold fabrication for cartilage engineering, the use of collagen type II has been advocated, as it is the major constituent of cartilage tissue.
Z Wu, SH Korntner, AM Mullen, I Skoufos, A Tzora, DI Zeugolis   +5 more
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