The novel missense mutation Met48Lys in FKBP22 changes its structure and functions. [PDF]
, 2020 Mutations in the FKBP14 gene encoding FKBP22 (FK506 Binding Protein 22 kDa) cause kyphoscoliotic Ehlers-Danlos Syndrome (kEDS). The first clinical report showed that a lack of FKBP22 protein due to mutations causing nonsense-mediated decay of the mRNA ...
Bächinger, Hans Peter +7 more
core
The biocompatibility of titanium in a buffer solution: compared effects of a thin film of TiO2 deposited by MOCVD and of collagen deposited from a gel [PDF]
, 2007 This study aims at evaluating the biocompatibility of titanium surfaces modified according two different ways: (i) deposition of a bio-inert, thin film of rutile TiO2 by chemical vapour deposition (MOCVD), and (ii) biochemical treatment with collagen gel,
Alain N. Gleizes +37 more
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Human COL2A1-directed SV40 T antigen expression in transgenic and chimeric mice results in abnormal skeletal development [PDF]
, 1995 The ability of SV40 T antigen to cause abnormalities in cartilage development in transgenic mice and chimeras has been tested. The cis- regulatory elements of the COL2A1 gene were used to target expression of SV40 T antigen to differentiating ...
Cheah, KSE +8 more
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Adipocyte, 2021 Visfatin reportedly induces the expression of proinflammatory cytokines. Severe grades of intervertebral disc disease (IVDD) exhibit higher expression of visfatin than mild ones.
Haitao Cui +7 more
doaj +1 more source
Collagen type II modification by hypochlorite.
Acta Biochimica Polonica, 2003 Oxidation of proteins is a common phenomenon in the inflammatory process mediated by highly reactive agents such as hypochlorite (HOCl/OCl(-)) produced by activated neutrophils. For instance, in rheumatoid arthritis hypochlorite plays an important role in joint destruction.
Olszowski, Sławomir +3 more
openaire +4 more sources
Juvenile arthritis and autoimmunity to type II collagen [PDF]
Arthritis & Rheumatism, 2001 Joint inflammation in juvenile rheumatoid arthritis (JRA) is sometimes associated with an autoimmune response to type II collagen (CII), a cartilage-specific protein. To test the hypothesis that down-regulation of autoimmunity to CII can be accomplished in JRA by oral administration of CII, an open-label study of CII was performed in 9 patients with ...
L K, Myers +12 more
openaire +2 more sources
Autoantibody recognition of collagen type II in arthritis [PDF]
, 2013 Autoantibodies against collagen type II (CII), a protein localized in the joint cartilage, play a major role in collagen-induced arthritis (CIA), one of the most commonly used animal models for rheumatoid arthritis (RA).
Lindh, Ingrid
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Genotype-phenotype correlation study in 364 osteogenesis imperfecta Italian patients [PDF]
, 2019 Osteogenesis imperfecta (OI) is a rare genetic disorder of the connective tissue and 90% of cases are due to dominant mutations in COL1A1 and COL1A2 genes.
Boarini, Manila +11 more
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Letter to the editor UC-II® Undenatured type II collagen: update to analytical methods
Journal of the International Society of Sports Nutrition, 2019 Supplementation with UC-II® undenatured type II collagen has been shown to provide joint health benefits for both healthy adults and adults with knee osteoarthritis in controlled clinical trials.
James P. Lugo
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AUTOIMMUNE ASPECTS OF COLLAGEN HOMEOSTASIS DISORDER IN UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA
Медицинская иммунология, 2014 . The levels of autoantibodies to collagen type I, II, III, IV and V were studied in blood plasma of 130 patients (18-32 years old) with undifferentiated connective tissue dysplasia, using immunoenzyme analysis.
A. V. Yagoda, N. N. Gladkikh
doaj +1 more source