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Collagen type II: From biosynthesis to advanced biomaterials for cartilage engineering [PDF]

Biomaterials and Biosystems, 2021
Collagen type II is the major constituent of cartilage tissue. Yet, cartilage engineering approaches are primarily based on collagen type I devices that are associated with suboptimal functional therapeutic outcomes. Herein, we briefly describe cartilage'
Z Wu, SH Korntner, AM Mullen, DI Zeugolis   +3 more
doaj   +2 more sources

A COL2A1 Mutation in Achondrogenesis Type II Results in the Replacement of Type II Collagen by Type I and III Collagens in Cartilage [PDF]

Journal of Biological Chemistry, 1995
An autosomal dominant mutation in the COL2A1 gene was identified in a fetus with achondrogenesis type II. A transition of G2853 to A in exon 41 produced a substitution of Gly769 by Ser within the triple helical domain of the alpha 1(II) chain of type II collagen, interrupting the mandatory Gly-X-Y triplet sequence required for the normal formation of ...
Danny Chan, William G. Cole, C.W. Chow, Stefan Mundlos, John F. Bateman   +4 more
openalex   +6 more sources

Undenatured type II collagen for knee osteoarthritis

Annals of Medicine
Introduction: Knee Osteoarthritis (OA) leads to significant pain and reduced function and affects patients’ overall quality of life (QoL). Conservative modalities are the first line of management, resorting to surgery only if they fail.
Ashim Gupta, Nicola Maffulli
doaj   +3 more sources

Type II collagen quantification in experimental chondrogenesis

Osteoarthritis and Cartilage, 1995
Type II collagen is an excellent indicator of the cartilage phenotype. Accurate quantification with existing methods requires about 100 micrograms of collagen. We have developed a method which allows for accurate quantification of type II collagen in samples as small as 1 microgram (and sample volumes as little as 1 microliters).
Shawn W. O’Driscoll, Cinzia N. Commisso, James S. Fitzsimmons   +2 more
openalex   +3 more sources

Bioprinting of Collagen Type I and II via Aerosol Jet Printing for the Replication of Dense Collagenous Tissues

Frontiers in Bioengineering and Biotechnology, 2021
Collagen has grown increasingly present in bioprinting, however collagen bioprinting has mostly been limited to the extrusion printing of collagen type I to form weak collagen hydrogels.
Rory Gibney, Rory Gibney, Eleonora Ferraris   +2 more
doaj   +1 more source

UC-II® undenatured type II collagen data show retention during functional food and beverage prototype processing

Data in Brief, 2023
Nowadays, collagen is widely used in food and beverage industries to enhance the nutritional and health value of the products. While many see this as an ideal way to incorporate more collagen into their diets, the exposure of these proteins to high ...
George Pates, Tyler White, Shane Durkee, Zainulabedin Saiyed   +3 more
doaj   +1 more source

Micronutrient optimization for tissue engineered articular cartilage production of type II collagen

Frontiers in Bioengineering and Biotechnology, 2023
Tissue Engineering of cartilage has been hampered by the inability of engineered tissue to express native levels of type II collagen in vitro. Inadequate levels of type II collagen are, in part, due to a failure to recapitulate the physiological ...
Maria A. Cruz, Yamilet Gonzalez, Javier A. Vélez Toro, Makan Karimzadeh, Anthony Rubbo, Lauren Morris, Ramapaada Medam, Taylor Splawn, Marilyn Archer, Russell J. Fernandes, James E. Dennis, Thomas J. Kean, Thomas J. Kean   +12 more
doaj   +1 more source

In the quest of the optimal tissue source (porcine male and female articular, tracheal and auricular cartilage) for the development of collagen sponges for articular cartilage

Biomedical Engineering Advances, 2021
Background: In the quest of the ideal material for scaffold fabrication for cartilage engineering, the use of collagen type II has been advocated, as it is the major constituent of cartilage tissue.
Z Wu, SH Korntner, AM Mullen, I Skoufos, A Tzora, DI Zeugolis   +5 more
doaj   +1 more source

Dynamic compression inhibits cytokine-mediated type II collagen degradation

Osteoarthritis and Cartilage Open, 2022
Objective: To examine the effect of dynamic compressive loading applied intermittently on bovine cartilage explants stimulated with proinflammatory cytokines over 21 days. Design: Cartilage explants were cultured for 21 days with Oncostatin M and TNFα (O 
Amalie Engstrøm, Frederik S. Gillesberg, Anne-Christine Bay Jensen, Morten A. Karsdal, Christian S. Thudium   +4 more
doaj   +1 more source

Altered collagen I and premature pulmonary embryonic differentiation in patients with OI type II

Physiological Reports, 2023
Pulmonary hypoplasia and respiratory failure are primary causes of death in patients with osteogenesis imperfecta (OI) type II. OI is a genetic skeletal disorder caused by pathogenic variants in genes encoding collagen type I.
S. Storoni, L. Celli, M. Breur, D. Micha, S. J. E. Verdonk, A. Maugeri, J. G. van denAardweg, M. Riminucci, E. M. W. Eekhoff, M. Bugiani   +9 more
doaj   +1 more source