Results 11 to 20 of about 286,259 (308)

Collagen type IX: Evidence for covalent linkages to type II collagen in cartilage

FEBS Letters, 1987
A major site of pyridinoline cross‐linking in bovine type IX collagen was traced to a tryptic peptide derived from one of the molecule's HMW chains. This peptide gave two amino acid sequences (in ratio) consistent with it being a three‐chained structure.
Eyre, David R., Apon, Stephen, Wu, Jiann-Jiu, Ericsson, Lowell H., Walsh, Kenneth A.   +4 more
openaire   +3 more sources

Type II collagen quantification in experimental chondrogenesis

Osteoarthritis and Cartilage, 1995
Type II collagen is an excellent indicator of the cartilage phenotype. Accurate quantification with existing methods requires about 100 micrograms of collagen. We have developed a method which allows for accurate quantification of type II collagen in samples as small as 1 microgram (and sample volumes as little as 1 microliters).
O'Driscoll, Shawn W., Commisso, Cinzia N., Fitzsimmons, James S.   +2 more
openaire   +3 more sources

Isolation and Characterisation of Major and Minor Collagens from Hyaline Cartilage of Hoki (Macruronus novaezelandiae)

Marine Drugs, 2019
The composition and properties of collagen in teleost (bony fish) cartilage have never been studied. In this study, we aimed to identify and characterise all collagen species in the nasal cartilage of hoki (Macruronus novaezelandiae).
Mathew H. Cumming, Bronwyn Hall, Kathleen Hofman   +2 more
doaj   +1 more source

Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis [PDF]

, 2009
Antibodies to citrulline-modifi ed proteins have a high diagnostic value in rheumatoid arthritis (RA). However, their biological role in disease development is still unclear.
Rikard Holmdahl, Bockermann, Robert, Hüseyin Uysal, Sehnert, Bettina,, Harald Burkhardt, Robert Bockermann, Bockermann, R, Nandakumar, Kutty S, Bajtner, Estelle,, Engstrom, A, Thunnissen, Marjolein M G M, Uysal, H,, Serre, Guy, Serre, G, Holmdahl, R,, Nandakumar, Kutty Selva,, Bajtner, E, Holmdahl, Rikard, Uysal, Hüseyin,, Burkhardt, Harald,, Burkhardt, H, Kutty Selva, Nandakumar,, Kutty S. Nandakumar, Bettina Sehnert, Thunnissen, MMGM, Serre, Guy,, Nandakumar, Kutty S., Burkhardt, Harald, Engström, Åke, Thunnissen, Marjolein,, Guy Serre, Engström, Åke,, Thunnissen, Marjolein M. G. M., Thunnissen, Marjolein M. G. M.,, Sehnert, B, Åke Engström, Sehnert, Bettina, Kutty Selva, Nandakumar, Nandakumar, KS, Estelle Bajtner, Lund University., Bajtner, Estelle, Thunnissen, Marjolein, Marjolein M.G.M. Thunnissen, Bockermann, Robert,, Holmdahl, Rikard,, Uysal, Hüseyin   +46 more
core   +1 more source

Early detection of osteoarthritis in the rat with an antibody specific to type II collagen modified by reactive oxygen species

Arthritis Research & Therapy, 2021
Background Osteoarthritis (OA) is a disease of the whole joint, with articular cartilage breakdown as a major characteristic. Inflammatory mediators, proteases, and oxidants produced by chondrocytes are known to be responsible for driving cartilage ...
Anne Gigout, Donata Harazin, Louise M. Topping, Didier Merciris, Sven Lindemann, Christian Brenneis, Ahuva Nissim   +6 more
doaj   +1 more source

Comparison of the solophenyl-red polarization method and the immunohistochemical analysis for collagen type III [PDF]

, 1992
In the present study, we have compared the staining pattern of the Solophenyl-Red 3 BL-method for the visualization of collagen type III with the immunohistochemical staining in serial sections from 7 skin wounds (wound age 3 days up to 4 weeks) to ...
Penning, R., Eisenmenger, Wolfgang, Nerlich, A., Wilske, J., Betz, P., Wiest, I.   +5 more
core   +1 more source

A COL2A1 Mutation in Achondrogenesis Type II Results in the Replacement of Type II Collagen by Type I and III Collagens in Cartilage [PDF]

Journal of Biological Chemistry, 1995
An autosomal dominant mutation in the COL2A1 gene was identified in a fetus with achondrogenesis type II. A transition of G2853 to A in exon 41 produced a substitution of Gly769 by Ser within the triple helical domain of the alpha 1(II) chain of type II collagen, interrupting the mandatory Gly-X-Y triplet sequence required for the normal formation of ...
Chan, D, Cole, WG, Chow, CW, Mundlos, S, Bateman, JF   +4 more
openaire   +4 more sources

Epicutaneous immunization with type II collagen inhibits both onset and progression of chronic collagen-induced arthritis. [PDF]

, 2007
Epicutaneous immunization is a potential non-invasive technique for antigen-specific immune-modulation. Topical application of protein antigens to barrier-disrupted skin induces potent antigen-specific immunity with a strong Th2-bias.
Strobel, S, Strid, J, Callard, R, Marco Londei, Londei, M, Lee Aun Tan, Stephan Strobel, Robin Callard, Jessica Strid, Tan, LA   +9 more
core   +1 more source

Efficacy and safety of native type II collagen in modulating knee osteoarthritis symptoms: a randomised, double‐blind, placebo‐controlled trial

Journal of Experimental Orthopaedics, 2022
Purpose Knee osteoarthritis (OA) is the most common form of clinical arthritis in middle‐aged and older individuals. Undenatured or native type II (TII) collagen derived from the chicken sternum has a good therapeutic effect on relieving severe pain of ...
Cheng Luo, Weike Su, Ying Song, Shalini Srivastava   +3 more
doaj   +1 more source

Visualization and phenotyping of proinflammatory antigen-specific T cells during collagen-induced arthritis in a mouse with a fixed collagen type II-specific transgenic T-cell receptor beta-chain [PDF]

, 2010
Introduction: The Vbeta12-transgenic mouse was previously generated to investigate the role of antigen-specific T cells in collagen-induced arthritis (CIA), an animal model for rheumatoid arthritis. This mouse expresses a transgenic collagen type II (CII)
Burkhardt, H, Dzhambazov, Balik, Bockermann, Robert, Bettina Sehnert, Batsalova, Tsvetelina, Harald Burkhardt, Burkhardt, Harald, Robert Bockermann, Baecklund, Johan, Batsalova, T, Bockermann, R, Dzhambazov, B, Merky, Patrick, Baecklund, J, Bäcklund, Johan, Sehnert, B, Patrick Merky, Sehnert, Bettina, Balik Dzhambazov, Tsvetelina Batsalova, Lund University., Johan Backlund, Merky, P,, Bockermann, Robert,   +23 more
core   +1 more source