Results 41 to 50 of about 286,259 (308)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Reduction of the Serum Levels of a Specific Biomarker of Cartilage Degradation (Coll2-1) by Hyaluronic Acid (KARTILAGE® CROSS) Compared to Placebo in Painful Knee Osteoarthritis Patients: the EPIKART Study, a Pilot Prospective Comparative Randomized Double Blind Trial

BMC Musculoskeletal Disorders, 2017
Background Viscosupplementation is a symptomatic treatment of the knee osteoarthritis based on the intra-articular injection of hyaluronic acid (IAHA). Although many studies have investigated its effect on symptoms, few clinical studies have focused on ...
Yves Henrotin, Francis Berenbaum, Xavier Chevalier, Marc Marty, Pascal Richette, François Rannou   +5 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Second harmonic generation confocal microscopy of collagen type I from rat tendon cryosections

, 2006
We performed second harmonic generation (SHG) imaging of collagen in rat-tendon cryosections, using femtosecond laser scanning confocal microscopy, both in backscattering and transmission geometries.
Theodossiou, Theodossis A., Thrasivoulou, C, Chidi Ekwobi, Ekwobi, Chidi, Theodossiou, TA, Becker, DL, Becker, David L., David L. Becker, Christopher Thrasivoulou, Thrasivoulou, Christopher, Theodossis A. Theodossiou, Ekwobi, C   +11 more
core   +1 more source

Efficacy and tolerability of native (undenatured) type II collagen supplementation for joint health in healthy volunteers: a randomized double-blind placebo-controlled study

Nutrition Journal
Background In non-osteoarthritic individuals, the appearance of joint discomfort with physical activity is a potential indicator of initial joint degeneration. The present study aimed to evaluate the efficacy and tolerability of native (undenatured) type-
Ingrid Möller, Kirsten Martínez, Andrea Terradillos-Guillén, Ester Costa-Larrión, Daniel Martínez-Puig, Javier Velasco-Álvarez   +5 more
doaj   +1 more source

Long non-coding RNA PVT1, a molecular sponge of miR-26b, is involved in the progression of hyperglycemia-induced collagen degradation in human chondrocytes by targeting CTGF/TGF- signal ways

Innate Immunity, 2020
The current study was conducted to investigate the role of long non-coding RNA PVT1 in hyperglycemia-triggered human osteoarthritis (OA) chondrocytes. Cartilage from knee OA patients with and without diabetes, as well as normal cartilage, was obtained ...
Luo-Bin Ding, Yao Li, Guang-Yuan Liu, Tai-Hang Li, Feng Li, Jian Guan, Hua-Jun Wang   +6 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Differential cartilaginous tissue formation by human synovial membrane, fat pad, meniscus cells and articular chondrocytes [PDF]

, 2007
Objective: To identify an appropriate cell source for the generation of meniscus substitutes, among those which would be available by arthroscopy of injured knee joints.
A. Marsano, Jakob, M., I. Martin, E. Kon, Tognana, E., Nehrer, S., D.M. Salter, E. Tognana, Marsano, A., Adesida, A., Hardingham, T., Salter, D.M., S.J. Millward-Sadler, Salter, D. M., A. Adesida, S. Nehrer, T. Hardingham, Chiari-Grisar, C., Kon, E., Martin, I., Millward-Sadler, S. J., M. Jakob, C. Chiari-Grisar, Millward-Sadler, S.J.   +23 more
core   +1 more source

Antigen presentation of Type II collagen in rats [PDF]

Clinical and Experimental Immunology, 2001
SummaryCollagen-induced arthritis (CIA) is a T-cell dependent disease of rats which follows immunization with bovine type II collagen (bCII). Susceptibility to CIA is linked to the genes encoding the major histocompatibility complex (MHC), suggesting that antigen presentation is important in disease pathogenesis.
B, Catchpole, N A, Staines, A S, Hamblin
openaire   +2 more sources