Results 61 to 70 of about 286,259 (308)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The potential of undenatured type II collagen against arthritis: a review

Collagen and Leather
The increasing global aging population has led to a continual rise in the prevalence of bone and joint diseases, posing challenges to both the quality of life for patients and healthcare resources. Type II collagen, a pivotal protein for sustaining joint
Yuhao Zhou, Yuer Zhang, Hongjie Dai, Yuhao Zhang, Yu Fu   +4 more
doaj   +1 more source

Characterization of collagen response to bone fracture healing using polarization-SHG

Scientific Reports, 2022
In this study, we extend on the three parameter analysis approach of utilizing a noninvasive dual-liquid–crystal-based polarization-resolved second harmonic generation (SHG) microscopy to facilitate the quantitative characterization of collagen types I ...
Anupama Nair, Shu-Chun Chuang, Yi-Shan Lin, Chung-Hwan Chen, Ting-Chen Fang, Hsiao-Chi Chiu, Chi-Hsiang Lien, Shean-Jen Chen   +7 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Anti-Inflammatory Effects of HDL in Mice With Rheumatoid Arthritis Induced by Collagen

Frontiers in Immunology, 2018
ObjectiveTo investigate the anti-inflammatory effects of high-density lipoprotein (HDL) in mice with rheumatoid arthritis (RA) induced by collagen.MethodsMale DBA/1 mice (8-week-old) were divided into three groups: control (treated with saline), collagen-
Yunlong Wang, Shulai Lu, Guoqing Zhang, Shaofeng Wu, Ying Yan, Qingzhe Dong, Bin Liu   +6 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The signs of differentiation of chondrocytes in the formation of early cartilage lesions in the elderly

Научно-практическая ревматология, 2011
Objective. To study the relationship between the activity of collagen type II cleavage and the pattern of expression of the genes responsible for chondrocyte differentiation in the areas of intact cartilaginous tissue and in those of early focal ...
Elena Vasil'evna Chetina, Elena Vasilyevna Chetina   +1 more
doaj   +1 more source

Arthritogenicity of collagen type II is increased by chlorination

Clinical and Experimental Immunology, 2006
Summary During inflammation, activated neutrophils, monocytes and macrophages produce and release myeloperoxidase (MPO). MPO converts hydrogen peroxide to hypochlorous acid, a highly reactive and oxidizing agent. Proteins subjected to hypochlorous acid become chlorinated.
E, Westman, K, Lundberg, H, Erlandsson Harris   +2 more
openaire   +3 more sources

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Region specific microstructural complexity of the ovine meniscus root provides an organizational basis for injury susceptibility

Scientific Reports
Comprehensive information on the meniscus root microstructure is essential to exactly understand its physiological role and susceptibility to injury. We selected the ovine medial meniscus anterior root (MAR) as model to elucidate the intricate spatial ...
Marta Carretero-Hernández, Yin Zhang, Wei Liu, Magali Cucchiarini, Henning Madry   +4 more
doaj   +1 more source