Results 51 to 60 of about 1,359,174 (352)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Long non-coding RNA PVT1, a molecular sponge of miR-26b, is involved in the progression of hyperglycemia-induced collagen degradation in human chondrocytes by targeting CTGF/TGF- signal ways

Innate Immunity, 2020
The current study was conducted to investigate the role of long non-coding RNA PVT1 in hyperglycemia-triggered human osteoarthritis (OA) chondrocytes. Cartilage from knee OA patients with and without diabetes, as well as normal cartilage, was obtained ...
Luo-Bin Ding, Yao Li, Guang-Yuan Liu, Tai-Hang Li, Feng Li, Jian Guan, Hua-Jun Wang   +6 more
doaj   +1 more source

Biochemical and immuno-histochemical localization of type IIA procollagen in annulus fibrosus of mature bovine intervertebral disc

Matrix Biology Plus, 2021
For next generation tissue-engineered constructs and regenerative medicine to succeed clinically, the basic biology and extracellular matrix composition of tissues that these repair techniques seek to restore have to be fully determined. Using the latest
Audrey McAlinden, David M. Hudson, Aysel A. Fernandes, Soumya Ravindran, Russell J. Fernandes   +4 more
doaj   +1 more source

Delivering rhFGF-18 via a bilayer collagen membrane to enhance microfracture treatment of chondral defects in a large animal model. [PDF]

, 2015
Augmented microfracture techniques use growth factors, cells, and/or scaffolds to enhance the healing of microfracture-treated cartilage defects. This study investigates the effect of delivering recombinant human fibroblastic growth factor 18 (rhFHF18 ...
Guehring, Hans, Henson, Frances, Howard, Daniel, Wardale, John   +3 more
core   +2 more sources

Collagen type IX: Evidence for covalent linkages to type II collagen in cartilage

FEBS Letters, 1987
A major site of pyridinoline cross‐linking in bovine type IX collagen was traced to a tryptic peptide derived from one of the molecule's HMW chains. This peptide gave two amino acid sequences (in ratio) consistent with it being a three‐chained structure.
Eyre, David R., Apon, Stephen, Wu, Jiann-Jiu, Ericsson, Lowell H., Walsh, Kenneth A.   +4 more
openaire   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Exposure to Mimivirus collagen promotes arthritis [PDF]

, 2014
Collagens, the most abundant proteins in animals, also occur in some recently described nucleocytoplasmic large DNA viruses such as Mimiviridae, which replicate in amoebae.
Gay, Steffen, Hennet, Thierry, Hochhold, Nina, Hülsmeier, Andreas J, Neidhart, Michel, Shah, Nikunj   +5 more
core   +1 more source

Type 1 regulatory T cells specific for collagen type II as an efficient cell-based therapy in arthritis

Arthritis Research & Therapy, 2014
IntroductionRegulatory T (Treg) cells play a crucial role in preventing autoimmune diseases and are an ideal target for the development of therapies designed to suppress inflammation in an antigen-specific manner.
H. Asnagli, D. Martire, N. Belmonte, J. Quentin, Hervé Bastian, M. Boucard-Jourdin, P. B. Fall, Anne-Laure Mausset-Bonnefont, Amélie Mantello-Moreau, S. Rouquier, Irène Marchetti, C. Jorgensen, A. Foussat, P. Louis‐Plence   +13 more
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Reduction of the Serum Levels of a Specific Biomarker of Cartilage Degradation (Coll2-1) by Hyaluronic Acid (KARTILAGE® CROSS) Compared to Placebo in Painful Knee Osteoarthritis Patients: the EPIKART Study, a Pilot Prospective Comparative Randomized Double Blind Trial

BMC Musculoskeletal Disorders, 2017
Background Viscosupplementation is a symptomatic treatment of the knee osteoarthritis based on the intra-articular injection of hyaluronic acid (IAHA). Although many studies have investigated its effect on symptoms, few clinical studies have focused on ...
Yves Henrotin, Francis Berenbaum, Xavier Chevalier, Marc Marty, Pascal Richette, François Rannou   +5 more
doaj   +1 more source