Results 31 to 40 of about 82,646 (203)

Transcriptional activity of heparan sulfate biosynthetic machinery is specifically impaired in benign prostate hyperplasia and prostate cancer

Frontiers in Oncology, 2014
Heparan sulfates (HS) are key components of mammalian cells surface and extracellular matrix. Structure and composition of HS, generated by HS biosynthetic system through non-template driven process, are significantly altered in cancer tissues.
Anastasia V Suhovskih, Anastasia V Suhovskih, Aneksandra Y Tsidulko, Olesya S Kutsenko, Anna V Kovner, Svetlana V Aidagulova, Ingemar eErnberg, Elvira V Grigorieva, Elvira V Grigorieva   +8 more
doaj   +1 more source

Supramolecular structure of a new family of circular proteoglycans mediating cell adhesion in sponges [PDF]

, 2000
Jarchow J, Fritz J, Anselmetti D, et al. Supramolecular structure of a new family of circular proteoglycans mediating cell adhesion in sponges. Journal of structural biology.
Fritz, Jürgen, Gerosa, Daniela, Burger, Max M., Calabro, Anthony, Fernandez-Busquets, Xavier, Hascall, Vincent C., Jarchow, Janina, Anselmetti, Dario ; https://orcid.org/   +7 more
core   +1 more source

The podocyte and the proteoglycan [PDF]

American Journal of Physiology-Renal Physiology, 2016
proteoglycans (PGs) consist of a core protein and linear sugar side chains [glycosaminoglycans (GAGs)] attached to the core protein, e.g., agrin, perlecan, glypican, and syndecan. GAGs comprise repeating duplex sugar units made of an aminosugar (e.g., N -acetylglucosamine or N -acetylgalactosamine)
openaire   +2 more sources

Intra-individual comparison of human ankle and knee chondrocytes in vitro: relevance for talar cartilage repair [PDF]

, 2009
OBJECTIVE: As compared to knee chondrocytes (KC), talar chondrocytes (TC) have superior synthetic activity and increased resistance to catabolic stimuli. We investigated whether these properties are maintained after TC are isolated and expanded in vitro.
Bonacina, E, Martin, I, Jakob, M, Frueh, J. A., Barbero, A, Bonacina, E., Jakob, M., Heberer, M, Frueh, JA, Frueh, J.A., Wirz, D., Vonwil, D., Barbero, A., Dickinson, S., Martin, I., Candrian, C., Heberer, M., Vonwil, D, Dickinson, SC, Candrian, C, Wirz, D   +20 more
core   +1 more source

Chemotherapy-Induced Degradation of Glycosylated Components of the Brain Extracellular Matrix Promotes Glioblastoma Relapse Development in an Animal Model

Frontiers in Oncology, 2021
Adjuvant chemotherapy with temozolomide (TMZ) is an intrinsic part of glioblastoma multiforme (GBM) therapy targeted to eliminate residual GBM cells.
Alexandra Y. Tsidulko, Oleg B. Shevelev, Anna S. Khotskina, Mariia A. Kolpakova, Anastasia V. Suhovskih, Anastasia V. Suhovskih, Galina M. Kazanskaya, Alexander M. Volkov, Svetlana V. Aidagulova, Evgenii L. Zavyalov, Elvira V. Grigorieva, Elvira V. Grigorieva   +11 more
doaj   +1 more source

Extracellular Matrix of Echinoderms

Marine Drugs, 2023
This review considers available data on the composition of the extracellular matrix (ECM) in echinoderms. The connective tissue in these animals has a rather complex organization.
Igor Yu. Dolmatov, Vladimir A. Nizhnichenko   +1 more
doaj   +1 more source

The Effect of Intense Exercise on Equine Serum Proteoglycan-4/Lubricin

Frontiers in Veterinary Science, 2020
Objective: Local biological and biomechanical-stimuli modulate proteoglycan-4 secretion within synovial joints. For the horse, changes to proteoglycan-4 concentration and function are notable in acute joint injury and osteoarthritis. Proteoglycan-4 (also
Austyn Matheson, Suresh C. Regmi, Gregory D. Jay, Tannin A. Schmidt, W. Michael Scott, W. Michael Scott   +5 more
doaj   +1 more source

Proteoglycans and catabolic products of proteoglycans present in ligament [PDF]

Biochemical Journal, 2005
The aim of the present study was to characterize the proteoglycans and catabolic products of proteoglycans present in the tensile region of ligament and explant cultures of this tissue, and to compare these with those observed in the tensile region of tendon. Approx.
Ilic, Mirna Z., Carter, Phillip., Tyndall, Alicia., Dudhia, Jayesh., Handley, Christopher J.   +4 more
openaire   +2 more sources

The conserved transmembrane proteoglycan Perdido/Kon-tiki is essential for myofibrillogenesis and sarcomeric structure in Drosophila [PDF]

, 2014
M.B. was funded by a Wellcome Trust Senior Investigator Award to P. Lawrence (WT096645MA).Muscle differentiation requires the assembly of high-order structures called myofibrils, composed of sarcomeres.
Estrada, B, Pérez-Moreno, J J, Martín-Bermudo, M D, Bischoff, M   +3 more
core   +2 more sources

The central role of vascular extracellular matrix and basement membrane remodeling in metabolic syndrome and type 2 diabetes: the matrix preloaded

Cardiovascular Diabetology, 2005
The vascular endothelial basement membrane and extra cellular matrix is a compilation of different macromolecules organized by physical entanglements, opposing ionic charges, chemical covalent bonding, and cross-linking into a biomechanically active ...
Tyagi Suresh C, Sowers James R, Hayden Melvin R   +2 more
doaj   +1 more source