Results 21 to 30 of about 82,646 (203)
Frontiers in Oncology, 2022 Extracellular and cell surface chondroitin sulfates (CSs) regulate cancer cell properties, including proliferation and invasion. Thus, it is necessary to understand the mechanisms underlying their roles in cancer.
Satomi Nadanaka +2 more
doaj +1 more source
Activin A-Mediated Regulation of XT-I in Human Skin Fibroblasts
Biomolecules, 2020 Fibrosis is a fundamental feature of systemic sclerosis (SSc) and is characterized by excessive accumulation of extracellular matrix components like proteoglycans (PG) or collagens in skin and internal organs.
Thanh-Diep Ly +7 more
doaj +1 more source
Syndecan receptors: pericellular regulators in development and inflammatory disease [PDF]
Open Biology, 2021 The syndecans are the major family of transmembrane proteoglycans, usually bearing multiple heparan sulfate chains. They are present on virtually all nucleated cells of vertebrates and are also present in invertebrates, indicative of a long evolutionary ...
Sandeep Gopal +4 more
doaj +1 more source
Intracellular proteoglycans [PDF]
Biochemical Journal, 2004 Proteoglycans (PGs) are proteins with glycosaminoglycan chains, are ubiquitously expressed and have a wide range of functions. PGs in the extracellular matrix and on the cell surface have been the subject of extensive structural and functional studies.
Svein Olav, Kolset +2 more
openaire +2 more sources
Angiotensin II Induces Aortic Rupture and Dissection in Osteoprotegerin‐Deficient Mice
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Background The biological mechanism of action for osteoprotegerin, a soluble decoy receptor for the receptor activator of nuclear factor‐kappa B ligand in the vascular structure, has not been elucidated.
Toshihiro Tsuruda +12 more
doaj +1 more source
Frontiers in Immunology, 2020 The attachment of a variety of Lactobacilli to the mucosal surfaces is accomplished through the interaction of OppA, a superficial bacterial protein also involved in oligopeptide internalization, and the glycosaminoglycan moiety of the proteoglycans that
Carla Martín +9 more
doaj +1 more source
Proteoglycans and Osteolysis [PDF]
, 2011 Osteolysis is a complex mechanism resulting from an exacerbated activity of osteoclasts associated or not with a dysregulation of osteoblast metabolism leading to bone loss. This bone defect is not compensated by bone apposition or by apposition of bone matrix with poor mechanical quality.
Baud'Huin, Marc +6 more
openaire +4 more sources
Biglycan : a multivalent proteoglycan providing structure and signals [PDF]
, 2013 Research over the past few years has provided fascinating results indicating that biglycan, besides being a ubiquitous structural component of the extracellular matrix (ECM), may act as a signaling molecule.
Schäfer, Liliana +2 more
core +1 more source
Proteoglycan-4: A Dynamic Regulator of Parathyroid Hormone Biologic Actions. [PDF]
, 2011 Intermittent parathyroid hormone (PTH) (1-34) is the only anabolic agent currently approved for the treatment of osteoporosis in the U.S. PTH (1-34) is under clinical investigations as a local bone regenerative therapy and as a potential stem cell ...
Novince, Chad M.
core +7 more sources
Quantification of collagen and proteoglycan deposition in a murine model of airway remodelling [PDF]
, 2005 Background: Sub- epithelial extracellular matrix deposition is a feature of asthmatic airway remodelling associated with severity of disease, decline in lung function and airway hyperresponsiveness.
Reinhardt Alistair K +11 more
core +2 more sources