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Conjugation of chondroitin sulfates with amines
Russian Journal of Bioorganic Chemistry, 2008Conjugation of chondroitin sulfates with pharmacologically important amines in a water medium in the presence of 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide was studied. Conjugates with amide and isoureidocarbonyl groups were synthesized.
E. S. Lukina +3 more
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Biosynthesis of Chondroitin/Dermatan Sulfate
IUBMB Life, 2002AbstractChondroitin sulfate and dermatan sulfate are synthesized as galactosaminoglycan polymers containing N ‐acetylgalactosmine alternating with glucuronic acid. The sugar residues are sulfated to varying degrees and positions depending upon the tissue sources and varying conditions of formation.
Jeremiah E. Silbert, Geetha Sugumaran
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Synthesis of Chondroitin Sulfate Oligosaccharides and Chondroitin Sulfate Glycopeptides
2019Chondroitin sulfate (CS) and chondroitin sulfate proteoglycan (CSPG) belong to the glycosaminoglycan (GAG) family, a class of poly-anionic glyco-conjugates widely expressed by animal cells. They play important roles in many biological events. Here, we summarize the main considerations in the design of chemical and enzymatic methodologies to access ...
Xuefei Huang +2 more
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Chondroitin Sulfate Proteoglycans in the Brain
2006Publisher Summary Chondroitin sulfate proteoglycans (CSPGs) play important roles in the morphogenesis and maintenance of various tissues, including the central nervous system (CNS), through the interactions of their core proteins and/or chondroitin sulfate (CS) chains with cell adhesion molecules, extracellular matrix (ECM) molecules, and growth ...
Sachiko Aono, Atsuhiko Oohira
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Chondroitin Sulfate in Osteoarthritis Therapy
Orthopedics, 2009Despite the news of aid from chondroitin sulfate, recent research has questioned its efficacy in treating osteoarthritis.
Jonathan D Morris, Kelly M. Smith
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Microbial production and metabolic engineering of chondroitin and chondroitin sulfate
Emerging Topics in Life Sciences, 2018Several commercial uses and potential novel applications have recently been described for chondroitin sulfate (CS). However, the currently applied animal extractive procedure has a high environmental impact, which may become more profound especially in relation to the forecasted expansion of the CS market for applications as a food supplement ...
Cimini D., Restaino O. F., Schiraldi C.
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Antioxidant Activity of Chondroitin Sulfate
2006Publisher Summary Molecules in biological systems often perform more than one function. Many structures have the ability to scavenge free radicals, acting in living organisms as antioxidants, although their main biological function is different. During oxidative stress, the increase in the concentration of these molecules seems to be a biological ...
Adriana Ferlazzo +4 more
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Isolation and Purification of Chondroitin Sulfate
2006Publisher Summary This chapter discusses methods for the isolation and purification of chondroitin sulfate (CS). This molecule is a sulfated glycosaminoglycan (GAG) composed of a linear polysaccharide chain with repeating disaccharides of defined structures that usually contain one hexosamine, one hexuronic acid, and a sulfate ester.
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In Vitro Effects of Chondroitin Sulfate
2006Publisher Summary A number of in vitro studies have been performed to determine the mode of action of chondroitin sulfate (CS). It has been demonstrated that CS possesses both anabolic effects on cartilage metabolism and anticatabolic properties. In various models of cartilage culture or of isolated chondrocytes, CS has demonstrated the capacity to ...
A. Fioravanti, G. Collodel
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Chondroitin Sulfate and RBC Clumping
Archives of Ophthalmology, 1984To the Editor. —Chondroitin sulfate is a new viscoelastic substance that is advocated as a protective agent for intraocular lens insertion. Chondroitin sulfate has been shown to be more effective in protecting the endothelium of animal and human corneas than other substances.1Contact of intraocular lenses with endothelium causes endothelial damage and
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