Results 111 to 120 of about 299,019 (288)

Improving protein secretion with autophagy‐inhibiting or proteasome‐activating small molecules

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Therapeutic proteins are produced frequently by mammalian cells in large‐scale bioreactors. As a result, producer cells are exposed to a chemically (nutrients, gas exchange, target protein overexpression) and physically (shear due to mixing) stressful environment, which can lead to endoplasmic reticulum (ER) stress and loss of ...
R Chauncey Splichal, Christina Chan, S Patrick Walton   +2 more
wiley   +1 more source

Use of natural ensiling additives with tropical grasses: Physicochemical properties, in vitro fermentation characteristics, and microbial community diversity indices

JSFA reports, EarlyView.
Abstract Background Improving feed quality, availability, and cost‐effectiveness is a big challenge for livestock to ensure animal‐derived food for nutritional security. The aim of the study was to find out how some natural ensiling additives affect physicochemical properties, proximate composition, microbial population, in vitro fermentation ...
A. B. M. Rubayet Bostami, A. S. M. Selim, M. Al‐Mamun, K. M. Islam, M. D. Hossain   +4 more
wiley   +1 more source

miR‐9 Restricts Insulin Secretion by Targeting Rab34, Which Mediates Lysosomal Degradation of Proinsulin

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Insulin secretion is a complex, vesicular transport process. Rab34 is a key regulator of intracellular vesicle transport; however, its role in insulin secretion has not yet been reported. miRNA‐9 is vital for the development and progression of the diagnosis and treatment of type 2 diabetes. This study aimed to investigate whether miR‐9 targets
Zhen‐Zhen Guo, Ao‐Ying Li, Ting‐Ting Xiang, Zu‐Hao Zhang, Ao Deng, Yang Han   +5 more
wiley   +1 more source

Defining sagittal knee phenotypes via monopedal static anterior tibial translation. Part 2: The assessment‐led personalization (ALP) system for indication and correction target planning in slope‐reducing osteotomy

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Current decision‐making for slope‐reducing osteotomy (SRO) often relies on isolated posterior tibial slope (PTS) thresholds, potentially misidentifying patients with acquired soft‐tissue decompensation or possibly overtreating those with an asymptomatic, inherently hyperlax baseline.
Mahmut Enes Kayaalp, Hamit Caglayan Kahraman, Tunay Erden, Christoph Lutter, Sven Scheffler, Omer Taser, Roland Becker, Michael T. Hirschmann, David H. Dejour   +8 more
wiley   +1 more source

The Relationship Between Human Activities and Ecosystem Service Supply–Demand From the Perspective of Land Use Transformation

Land Degradation &Development, EarlyView.
ABSTRACT The equilibrium between ecosystem service supply and demand relationships (ESSDR) is essential for regional sustainable development. Understanding the relationship between human activity intensity (HAI) and ESSDR from the perspective of land use transformation (LT) is important for ecological management and governance.
Rongping Liang, Wei Wei, Xiaoxu Wei, Binbin Xie, Junju Zhou, Qiaolin Shu, Yongcheng Wang   +6 more
wiley   +1 more source

Enhancing Soil Quality and Ecosystem Multifunctionality to Increase Maize Yield in Saline‐Alkali Soil: A Multisource Nitrogen Fertilization Strategy

Land Degradation &Development, EarlyView.
ABSTRACT The positive effect of multisource nitrogen fertilization strategies on improving soil fertility and crop yield in saline‐alkali soil has been evaluated. However, the responses of soil quality and ecosystem functions to multisource nitrogen fertilization strategies, and their roles in regulating maize yields in saline‐alkali soils remain ...
Yupeng Jing, Lanying Zhang, Meiying Liu, Yongqing Wang, Haiwen Duan, Bin Zhao, Weini Wang, Hongjin Liu, Zhigang Qiao, Jie Zhou, Xia Zhang   +10 more
wiley   +1 more source

Comparative Effectiveness of Different Mulch Types and Application Rates for Reducing Runoff and Sediment Yield on Forest Skid Trails

Land Degradation &Development, EarlyView.
ABSTRACT Rehabilitation of skid trails following timber harvesting is critical for preserving forest soil integrity, particularly within ecologically sensitive ecosystems such as the Hyrcanian forests of northern Iran, a UNESCO World Heritage Site. Although mulching is widely recommended for erosion control, field evidence comparing different locally ...
Masoumeh Ahmadi, Meghdad Jourgholami, Baris Majnounian, Shahram Khalighi Sigaroodi, Francesco Latterini, Rachele Venanzi, Angela Lo Monaco, Rodolfo Picchio   +7 more
wiley   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Servo Navigation and Phase Equalization Enhanced by Run‐Time Stabilization (PEERS) for 3D EPI Time Series

Magnetic Resonance in Medicine, EarlyView.
Purpose To enhance time‐resolved segmented imaging by synergy of run‐time stabilization and retrospective data‐driven phase correction. Methods A segmented 3D EPI sequence for fMRI time series is equipped with servo navigation based on short orbital navigators and a linear perturbation model, enabling run‐time correction for rigid‐body motion, bulk ...
Malte Riedel, Thomas Ulrich, Samuel Bianchi, Klaas P. Pruessmann   +3 more
wiley   +1 more source

Unveiling the health‐promoting potential of Sudanese sorghum landraces: A legacy rooted in Eastern Sudan, Kassala, and the Red Sea States

PLANTS, PEOPLE, PLANET, EarlyView.
Sorghum is a staple food for hundreds of millions of people in dry regions worldwide, and improving its nutritional quality is vital for global food and health security under climate change. In this study, we evaluated traditional Sudanese sorghum varieties grown in eastern deltas to better understand their natural health‐promoting properties. We found
Khitma A. Sir Elkhatim, Manhal Gobara Hamid, Ahmed Khalifa, Mahbubjon Rahmatov, Mohammed Elsafy, Tilal Abdelhalim   +5 more
wiley   +1 more source