Results 211 to 220 of about 123,498 (281)

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

open access: yesThe FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti   +11 more
wiley   +1 more source

Fatigue of AM TiAl6V4: Probabilistic Modelling of the Size Influence as a Transfer Method From Test Specimen to Part

open access: yesFatigue &Fracture of Engineering Materials &Structures, EarlyView.
ABSTRACT This paper investigates the fatigue behavior of additively manufactured TiAl6V4 by comparing two specimen geometries with different highly stressed volumes. A fracture mechanical approach based on the El‐Haddad–Smith–Topper model is combined with defect analysis through X‐ray computed tomography.
Sebastian Mansky   +2 more
wiley   +1 more source

π‑Conjugated Indole-Based 2D Perovskite Microcavities for Self-Powered Ultraviolet Photodetection. [PDF]

open access: yesChem Mater
Pegu M   +15 more
europepmc   +1 more source

Poorly differentiated lung adenocarcinomas with concurrent ALK and CD30 expression: a diagnostic pitfall mimicking ALK‐positive anaplastic large‐cell lymphoma

open access: yesHistopathology, EarlyView.
Poorly differentiated lung adenocarcinomas with concurrent anaplastic lymphoma kinase (ALK) and CD30 expression closely mimic ALK‐positive anaplastic large‐cell lymphoma, creating a significant diagnostic pitfall. Accurate classification requires comprehensive integration of clinical, radiologic, morphologic, immunophenotypic and molecular findings ...
Jietian Jin   +6 more
wiley   +1 more source

Broadband Fourier-Transform Optical Photothermal Infrared Spectroscopy and Imaging. [PDF]

open access: yesAnal Chem
Razumtcev A   +6 more
europepmc   +1 more source

Early‐life pathways to inequalities in child mental health: evidence from eight birth cohorts

open access: yesJournal of Child Psychology and Psychiatry, EarlyView.
Background Socioeconomic inequalities in children's emotional and behavioural problems are already present at school entry. We examined associations between early‐life socioeconomic conditions and children's externalising and internalising problems and assessed whether early‐life risk factors mediated these associations.
Demetris Avraam   +37 more
wiley   +1 more source

Male genital lichen sclerosus

open access: yesJournal of the European Academy of Dermatology and Venereology, EarlyView.
Male genital lichen sclerosus is driven by chronic, occluded exposure of susceptible genital epithelium to urine, rather than infection or autoimmunity. This review synthesizes clinical, anatomical and molecular evidence showing how microincontinence and occlusion initiate inflammation, fibrosis and carcinogenesis, and explains the curative effect of ...
Georgios Kravvas   +3 more
wiley   +1 more source

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