Results 151 to 160 of about 919,306 (297)

Hippo pathway effectors are associated with glioma patient survival, control cell proliferation and sterol metabolism through TEAD3

open access: yesBrain Pathology, Volume 35, Issue 6, November 2025.
The Hippo pathway transcription factor TEAD3 represents an independent prognostic biomarker of tumor recurrence and a potential therapeutic vulnerability through its regulation of cholesterol metabolism in glioma. Abstract Glioblastomas represent the most common and lethal primary brain tumors in the world.
Konstantin Masliantsev   +10 more
wiley   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

open access: yesMolecular Oncology, Volume 19, Issue 10, Page 2822-2832, October 2025.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia   +17 more
wiley   +1 more source

NAD+‐Boosters Improve Mitochondria Quality Control In Parkinson's Disease Models Via Mitochondrial UPR

open access: yesAdvanced Science, Volume 12, Issue 38, October 13, 2025.
Treatment of MPTP‐incubated cells with NAD+‐boosters increase the UPRmt/mitophagy‐related mitochondria quality control (MQC). Disturbed plasma UPRmt‐mitophagy‐mediated MQC profiles in PD patient samples. NMN inhibits motor deficit and forestalls neuropathology phenotypes of PD mice, which is required the atf4‐medicated UPRmt pathway.
Shuoting Zhou   +16 more
wiley   +1 more source

Single‐Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult Patients

open access: yesAdvanced Science, Volume 12, Issue 39, October 20, 2025.
scRNA sequencing reveals distinct tumor ecosystem features in CAYA‐PTC, marked by enriched CD4T_Tfh, CD8T_Tex cells, and rapid malignant thyrocyte differentiation (absent of mild‐state BRAF‐like population) toward invasive states. Prominent emCAF_LAMP5 populations interact with endothelial cells and thyrocytes facilitate angiogenesis and metastasis ...
Kai Guo   +15 more
wiley   +1 more source

Aligned Conductive Magnetic Nanofibers with Directional Magnetic Field Stimulation Promotes Peripheral Nerve Regeneration

open access: yesAdvanced Science, Volume 12, Issue 37, October 6, 2025.
Peripheral nerve injury necessitates alternatives to autografts. This study combines magnetic nanoparticles, oriented PCL fibers, and Ppy to create a conductive, magnetically active scaffold. In vitro and in vivo experiments demonstrated enhanced downstream pathways of calcium signaling, as revealed by transcriptome analysis.
Zheyuan Fan   +4 more
wiley   +1 more source

Biomolecular Interaction Prediction: The Era of AI

open access: yesAdvanced Science, Volume 12, Issue 38, October 13, 2025.
This review offers a thorough examination of recent progress in deep learning for predicting biomolecular interactions, including those involving proteins, nucleic acids, and small molecules. It covers data processing strategies, representative model architectures, and evaluation metrics, while highlighting current methodological limitations.
Haoping Wang, Xiangjie Meng, Yang Zhang
wiley   +1 more source

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