Results 141 to 150 of about 946,691 (269)

A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment

Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.
A human cell‐based microphysiological system integrates engineered muscle tissues with an inflamed adipose–macrophage niche to model obese microenvironment‐induced muscle dysfunction. Muscle contraction is quantified by pillar deflection coupled with computational stiffness estimation. Secretome and transcriptomic profiling reveal inflammation‐mediated
Seunggyu Kim, Tianxin Cao, Zhengpeng Wan, Jaesang Kim, Zhuxuan Li, Legairre A. Radden II, Rakesh Santhanam, Eunkyung Clare Ko, Tatsuya Osaki, Sarah Spitz, Hyunmin Moon, Maria Proestaki, Seokbeom Roh, Gyudo Lee, Jessie S. Jeon, Curtis R. Warren, Roger D. Kamm   +16 more
wiley   +1 more source

Giga‐Voxel Multiscale Composite Architecture Mirrored Through a Data‐to‐Model Closed‐Loop Digital Twin

Advanced Materials, Volume 38, Issue 7, 2 February 2026.
Herein, a systematic digital twin workflow tailored for generating high‐fidelity virtual representations of anisotropic composite microstructures and giga‐voxel meso‐structural models is presented, leveraging a harmonious integration of top–down image‐based modeling and bottom–up data‐driven voxel generation.
Siwon Yu, Seungsoo Jang, Young Seok Cho, Seunggyu Park, Jun Yeon Hwang, Soon Hyung Hong, Thomas James Marrow, Kang Taek Lee   +7 more
wiley   +1 more source

Icaritin Ameliorates Cisplatin‐Induced Mitochondrial Metabolic Dysfunction‐Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy

Advanced Science, Volume 13, Issue 7, 3 February 2026.
In this study, scRNA‐seq and chemoproteomics are integrated to characterize CDDP‐bound proteins at single‐cell resolution in tumor‐bearing mice. Additionally, the research demonstrates that ICA alleviates CDDP‐induced nephrotoxicity while enhancing its chemotherapeutic efficacy.
Piao Luo, Junhui Chen, Yehai An, Kun Meng, Wei Zhou, Wenhui Li, Jing Liu, Wentong Zhao, Weiyi He, Ting Cao, Jingnan Huang, Sha Feng, Shiguang Yang, Hongling Hu, Jiaxian Liao, Hengkai He, Mingjing Hao, Qian Zhang, Jigang Wang, Yue Gao   +19 more
wiley   +1 more source

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source

Novel Vascularized Human Liver Organoids for Modeling Alcohol‐Induced Liver Injury and Developing Hepatoprotective Therapy

Advanced Science, Volume 13, Issue 9, 13 February 2026.
This study successfully engineered vascularized liver organoids (3HLOs) by co‐culturing human reprogrammed hepatocyte‐like cells (hrHLs) with human umbilical vein endothelial cells (HUVECs) and human umbilical mesenchymal stem cells (HUMSCs). Upon implantation, the 3HLOs established functional vascular anastomosis with the host circulation and ...
Kangdi Yang, Xiayan Chu, Xuerui Wang, Wenkun Zhang, Jinnuo Lu, Chuting Xu, Shoucheng Hu, Guoyu Pan, Chih‐Tsung Yang, Xiaohui Zhang, Shaojin Li, Zhaobin Guo, Hanyang Liu, Guangbo Ge   +13 more
wiley   +1 more source

Evolution of Multivalent Aptamer Corona for High‐Throughput Multiplexed Detection of Multiple Cancers

Advanced Science, Volume 13, Issue 8, 9 February 2026.
A multivalent aptamer corona is evolved via established ProteoFish‐SELEX (systematic evolution of ligands by exponential enrichment) for high‐throughput multiplexed detection of multiple cancers. Clinical validation using multivalent aptamer corona demonstrated high accuracy and specificity in multiplexed detection of ovarian, lung, and colorectal ...
Mengjie Wang, Baichuan Jin, Xin Dai, Haozhe Huang, Qiqi Liu, Jianqing Zhu, Haixing Ju, Qixun Chen, Yongmei Song, Weihong Tan, Yuan Liu   +10 more
wiley   +1 more source

Exploring Dominating Functions and Their Complexity in Subclasses of Weighted Chordal Graphs and Bipartite Graphs

Mathematics
Domination problems are fundamental problems in graph theory with diverse applications in optimization, network design, and computational complexity.
Chuan-Min Lee
doaj   +1 more source

The Correlations of Clinical Outcomes and Vascular Morphology With Infarct Patterns in Middle Cerebral Arterial Occlusion

Brain and Behavior, Volume 16, Issue 2, February 2026.
For stroke caused by large vessel occlusion in M1 segment of middle cerebral artery (MCA), a tortuous and long M1 segment of contralateral MCA (cMCA) correlates with the onset of borderzone infarct. In those with a less tortuous cMCA‐M1 segment, a thin and short M1 segment correlates with large infarct.
ZhiRong Cai, Yuan Chen, ShaoQing Pei, Yue He, YaNan Zhu, Rui Zhang, JingWei Lin, Yi Yang, Ying Zhu   +8 more
wiley   +1 more source

Single‐Cell RNA Sequencing and Bulk RNA Sequencing Revealed the Interplay Between Intratumoral Heterogeneity and the Tumor Microenvironment in Breast Cancer

Cancer Medicine, Volume 15, Issue 2, February 2026.
The figure shows single‐cell datasets of breast cancer collected from the GEO database, including estrogen receptor‐positive breast cancer, HER2‐positive breast cancer, and triple‐negative breast cancer. These datasets are used to analyze differences among breast cancer subtypes by studying the interactions among epithelial cells, fibroblasts ...
Yunlong Zhao, Xiaoyu Zhang, Yingying Wang, Xiaomin Yu, Fengchun Lv, Mingyu Gong, Xiu‐An Yang   +6 more
wiley   +1 more source

Reconfiguration Graph for Vertex Colourings of Weakly Chordal Graphs [PDF]

Discrete Mathematics, 2019
Carl Feghali, J. Fiala
semanticscholar   +1 more source