Results 171 to 180 of about 16,071 (223)
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Acta Orthopaedica, 1976
During the period 1953-1971, 20 cases of chordoma were reported to the Finnish Cancer Registry. Twelve of the patients were males. The mean annual (crude) incidence of chordoma in Finland was 0.30/10(6) in males, and 0.18/10(6) in females. Fifteen of the tumours were sacral, three vertebral, and two cranial.
Lyly Teppo +2 more
exaly +3 more sources
During the period 1953-1971, 20 cases of chordoma were reported to the Finnish Cancer Registry. Twelve of the patients were males. The mean annual (crude) incidence of chordoma in Finland was 0.30/10(6) in males, and 0.18/10(6) in females. Fifteen of the tumours were sacral, three vertebral, and two cranial.
Lyly Teppo +2 more
exaly +3 more sources
Personalized chordoma organoids for drug discovery studies
bioRxiv, 2021Chordomas are rare tumors of notochordal origin, most commonly arising in the sacrum or skull base. Primary treatment of chordoma is surgery, however complete resection is not always feasible due to their anatomic location, and recurrence rates remain ...
A. A. Shihabi +9 more
semanticscholar +1 more source
Chordoma: To know means to recognize.
Biochimica et biophysica acta. Reviews on cancer, 2022Chordoma is a rare type of bone cancer characterized by its locally aggressive and destructive behavior. Chordoma is located in one of the three primary regions: skull base/clivus, sacrum or mobile spine.
Emija Nikola Karele, Anda Nikola Paze
semanticscholar +1 more source
Current Opinion in Oncology, 2007
To review developments in chordoma treatment.Recent series with prolonged follow-up show that adequate margins are necessary for surgery to be curative. Safe margins are often difficult to obtain due to the anatomical sites of chordoma: sacrum, skull base and spine.
Paolo G, Casali +4 more
openaire +2 more sources
To review developments in chordoma treatment.Recent series with prolonged follow-up show that adequate margins are necessary for surgery to be curative. Safe margins are often difficult to obtain due to the anatomical sites of chordoma: sacrum, skull base and spine.
Paolo G, Casali +4 more
openaire +2 more sources
World Neurosurgery, 2022
INTRODUCTION Chondrosarcoma and chordoma are often grouped together because of their similar anatomic locations, clinical presentations, histopathological/radiological findings, and growth patterns.
H. Vuong, I. Dunn
semanticscholar +1 more source
INTRODUCTION Chondrosarcoma and chordoma are often grouped together because of their similar anatomic locations, clinical presentations, histopathological/radiological findings, and growth patterns.
H. Vuong, I. Dunn
semanticscholar +1 more source
Current Treatment Options in Neurology, 2002
Optimal therapy of chordoma is a combined approach of surgical resection followed by proton beam irradiation for residual disease. The goals of surgery are to establish a definitive diagnosis, obtain total or maximal resection, and "shape" any residual disease so that it is favorable for radiation. Given the difficult locations and large sizes of these
Saad, Khairi, Matthew G., Ewend
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Optimal therapy of chordoma is a combined approach of surgical resection followed by proton beam irradiation for residual disease. The goals of surgery are to establish a definitive diagnosis, obtain total or maximal resection, and "shape" any residual disease so that it is favorable for radiation. Given the difficult locations and large sizes of these
Saad, Khairi, Matthew G., Ewend
openaire +2 more sources
Small-molecule targeting of brachyury transcription factor addiction in chordoma
Nature Medicine, 2019Chordoma is a primary bone cancer with no approved therapy1. The identification of therapeutic targets in this disease has been challenging due to the infrequent occurrence of clinically actionable somatic mutations in chordoma tumors2,3.
Tanaz Sharifnia +29 more
semanticscholar +1 more source
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2014
Chordomas are malignant tumors of the axial skeleton, characterized by their locally invasive and slow but aggressive growth. These neoplasms are presumed to be derived from notochordal remnants with a molecular alteration preceding their malignant transformation.
Yakkioui, Youssef +4 more
openaire +3 more sources
Chordomas are malignant tumors of the axial skeleton, characterized by their locally invasive and slow but aggressive growth. These neoplasms are presumed to be derived from notochordal remnants with a molecular alteration preceding their malignant transformation.
Yakkioui, Youssef +4 more
openaire +3 more sources
Journal of the American Academy of Dermatology, 2005
Chordomas are rare malignant primary bone tumors, which most often occur in the sacral area. These tumors uncommonly affect the skin, and may not be recognized by dermatologists. We present a case of an adult woman with cutaneous metastasis of a primary sacral chordoma.
Adam I, Rubin +2 more
openaire +2 more sources
Chordomas are rare malignant primary bone tumors, which most often occur in the sacral area. These tumors uncommonly affect the skin, and may not be recognized by dermatologists. We present a case of an adult woman with cutaneous metastasis of a primary sacral chordoma.
Adam I, Rubin +2 more
openaire +2 more sources
Otolaryngologic Clinics of North America, 2015
Chordoma and chondrosarcoma represent 2 fundamentally different and challenging central skull base pathologies. Both are largely surgical diseases with varying outcomes based on completeness of resection. Adjuvant therapy is controversial, although radiation therapy is commonly employed postoperatively, and stereotactic radiosurgery is used either in ...
Jamie J, Van Gompel, Jeffrey R, Janus
openaire +2 more sources
Chordoma and chondrosarcoma represent 2 fundamentally different and challenging central skull base pathologies. Both are largely surgical diseases with varying outcomes based on completeness of resection. Adjuvant therapy is controversial, although radiation therapy is commonly employed postoperatively, and stereotactic radiosurgery is used either in ...
Jamie J, Van Gompel, Jeffrey R, Janus
openaire +2 more sources