Results 181 to 190 of about 16,071 (223)
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Apatinib in patients with advanced chordoma: a single-arm, single-centre, phase 2 study.
The Lancet Oncology, 2020BACKGROUND No standard treatment exists for advanced chordoma. Apatinib has been found to have promising efficacy and manageable adverse effects for the treatment of solid tumours. We aimed to investigate the safety and antitumour activity of apatinib in
Chao Liu +13 more
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Clinical Orthopaedics and Related Research, 1986
Chordomas constitute between 1% and 4% of primary malignant bone tumors. Approximately 50% originate in the sacrum, 35% at the base of the skull, and 15% in the true vertebrae. The majority of tumors are encountered from the fifth through seventh decades, with a male preponderance.
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Chordomas constitute between 1% and 4% of primary malignant bone tumors. Approximately 50% originate in the sacrum, 35% at the base of the skull, and 15% in the true vertebrae. The majority of tumors are encountered from the fifth through seventh decades, with a male preponderance.
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The British Journal of Radiology, 1977
The clinical and radiological features of 44 cranial chordomas are recorded. Classical features of a mid-line partially calcified tumour, destroying the clivus and causing a soft tissue mass in the sphenoid sinus or nasopharynx were present in about half of the cases. The high incidence of unilateral bone erosion which occurred in nearly a third of the
B. E. Kendall, B. C. P. Lee
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The clinical and radiological features of 44 cranial chordomas are recorded. Classical features of a mid-line partially calcified tumour, destroying the clivus and causing a soft tissue mass in the sphenoid sinus or nasopharynx were present in about half of the cases. The high incidence of unilateral bone erosion which occurred in nearly a third of the
B. E. Kendall, B. C. P. Lee
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Chordoma of the sacrum and mobile spine: a narrative review.
The spine journal, 2020Chordoma is a notochord-derived primary tumor of the skull base and vertebral column known to affect 0.08 to 0.5 per 100,000 persons worldwide. Patients commonly present with mechanical, midline pain with or without radicular features secondary to nerve ...
Z. Pennington +7 more
semanticscholar +1 more source
Journal of Neurosurgery, 1979
✓ A series of 54 patients with spinal chordomas were treated at Memorial Sloan-Kettering Cancer Center between 1949 and 1976. Thirty-six lesions were located in the sacrococcygeal region and 18 involved the vertebral column at a higher level. The male to female ratio was 35:19. Vertebral chordomas generally occurred in a younger age group.
N, Sundaresan +3 more
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✓ A series of 54 patients with spinal chordomas were treated at Memorial Sloan-Kettering Cancer Center between 1949 and 1976. Thirty-six lesions were located in the sacrococcygeal region and 18 involved the vertebral column at a higher level. The male to female ratio was 35:19. Vertebral chordomas generally occurred in a younger age group.
N, Sundaresan +3 more
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The Ultrastructure of Chordoma
American Journal of Clinical Pathology, 1970Electron microscopic examination of two chordomas provided evidence to clarify the histogenesis of the cytoplasmic vacuoles which characterize the light microscopic appearance of some of their cellular elements. Small vacuoles found in cells with “foamy cytoplasm” appear to represent dilated cisterns of coarse endoplasmic reticulum, whereas large forms
C E, Peña, B L, Horvat, E R, Fisher
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Neurosurgery clinics of North America, 2020
Surgery alone provides suboptimal local control of spine and sacral chordomas. Radiotherapy (RT) may improve local control in patients undergoing surgery and be used as definitive-intent treatment in patients not undergoing surgery. Although conventional-
D. Konieczkowski, T. Delaney, Y. Yamada
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Surgery alone provides suboptimal local control of spine and sacral chordomas. Radiotherapy (RT) may improve local control in patients undergoing surgery and be used as definitive-intent treatment in patients not undergoing surgery. Although conventional-
D. Konieczkowski, T. Delaney, Y. Yamada
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American Journal of Surgical Pathology, 2020
Supplemental Digital Content is available in the text. Dedifferentiated chordoma is a rare chordoma subtype characterized by a high-grade sarcoma juxtaposed to conventional chordoma.
Y. Hung +11 more
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Supplemental Digital Content is available in the text. Dedifferentiated chordoma is a rare chordoma subtype characterized by a high-grade sarcoma juxtaposed to conventional chordoma.
Y. Hung +11 more
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Australasian Radiology, 1993
SUMMARY Three cases of clival chordomas are reviewed and the findings are compared to those in the recent literature. In the first case the tumour arose from the basion, spreading downwards to invade the upper cervical canal and the paravertebral fascial planes. The second case is a rare case since it affects a 12 year old pre‐adolescent boy. The third
R G, Schamschula, M Y, Soo
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SUMMARY Three cases of clival chordomas are reviewed and the findings are compared to those in the recent literature. In the first case the tumour arose from the basion, spreading downwards to invade the upper cervical canal and the paravertebral fascial planes. The second case is a rare case since it affects a 12 year old pre‐adolescent boy. The third
R G, Schamschula, M Y, Soo
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The American Journal of Surgery, 1979
In a 20 year period seven cases of craniocervical chordoma were seen and treated. Since it is not possible to completely resect these lesions, the aim of treatment has been to debulk the tumor as much as feasible and employ postoperative irridation. Palliation is the most that can be hoped for, and minimal success in delaying the natural history of the
R D, Harwick, A S, Miller
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In a 20 year period seven cases of craniocervical chordoma were seen and treated. Since it is not possible to completely resect these lesions, the aim of treatment has been to debulk the tumor as much as feasible and employ postoperative irridation. Palliation is the most that can be hoped for, and minimal success in delaying the natural history of the
R D, Harwick, A S, Miller
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