Results 111 to 120 of about 47,826 (261)

Huntington\u27s Disease--A Review [PDF]

, 2016
Huntington’s disease is degenerative and effects both cognitive and motor functioning, beginning in the 20s and continuing a decline for about two decades until death.
Dunn, Christen
core   +1 more source

Cortical and Striatal Circuits in Huntington's Disease

, 2020
Huntington's disease (HD) is a hereditary neurodegenerative disorder that typically manifests in midlife with motor, cognitive, and/or psychiatric symptoms.
Blumenstock, S., Dudanova, I.
core   +1 more source

An Adult with Episodic Abnormal Limb Posturing [PDF]

, 2018
info:eu-repo/semantics ...
Costa, C, Leitão, L, Lobo, P, Rebordão, L, Santos, M   +4 more
core   +1 more source

The cerebellum in epilepsy

Epilepsia, EarlyView.
Abstract The cerebellum, a subcortical structure, is traditionally linked to sensorimotor integration and coordination, although its role in cognition and affective behavior, as well as epilepsy, is increasingly recognized. Cerebellar dysfunction in patients with epilepsy can result from genetic disorders, antiseizure medications, seizures, and seizure‐
Christopher Elder, Rebecca Kerestes, Puneet Opal, Maria Marchese, Orrin Devinsky   +4 more
wiley   +1 more source

Benign hereditary chorea: clinical and neuroimaging features in an Italian family. [PDF]

, 2010
: Benign hereditary chorea is an autosomal domi- nant disorder characterized by early onset nonprogressive chorea, caused by mutations of the thyroid transcription factor-1 (TITF-1) gene.
DE MICHELE, GIUSEPPE, Di Maio L, FERRARA, ALFONSO MASSIMILIANO, FILLA, ALESSANDRO, MACCHIA, PAOLO EMIDIO, Pappatà S, PELUSO, SILVIO, RINALDI, CARLO, SACCA', FRANCESCO, SALVATORE, ELENA   +9 more
core   +1 more source

The microbiota–gut–brain axis in Huntington's disease: pathogenic mechanisms and therapeutic targets

The FEBS Journal, Volume 292, Issue 6, Page 1282-1315, March 2025.
Disturbances of the microbiota–gut–brain axis are evident in people with Huntington's disease (HD) and in HD animal models. Here, we provide an overview of how the trillions of microorganisms residing in the gut, their secretory products, and the microbiota–gut–brain axis may contribute to HD pathogenesis.
Millicent N. Ekwudo, Carolina Gubert, Anthony J. Hannan   +2 more
wiley   +1 more source

Brain SPECT imaging in Sydenham's chorea [PDF]

, 2002
The objective of the present study was to determine whether brain single-photon emission computed tomography (SPECT) imaging is capable of detecting perfusional abnormalities.
Barbieri, A., Barsottini, Orlando Graziani Povoas, Ferraz, H.b., Sevillano, Marta Maite   +3 more
core   +3 more sources

A Scoping Review of the Lived Experiences of Individuals With Huntington's Disease, Their Informal Caregivers and Offspring

Journal of Advanced Nursing, EarlyView.
ABSTRACT Background Huntington's disease has a disruptive effect on entire families. While previous reviews have examined lived experiences of individuals with Huntington's Disease, their informal caregivers, or their offspring, none have provided a comprehensive overview that integrates these three perspectives. Design A scoping review. Aims Providing
Cathelijn Van Baar, Kristel Kalkers, Sascha Bolt, Raymund Roos, Robbert Gobbens   +4 more
wiley   +1 more source

Profiling Swallowing Safety and Physiology in People With Huntington's Disease

Neurogastroenterology &Motility, EarlyView.
We assessed swallowing in HD using the PAS and MBSImP. Safety profiles: 65% safe, 7.5% penetration, and 27.5% aspiration. Oral phase: 85% none‐to‐mild and 15% moderate severity. Pharyngeal phase: 97.5% none‐to‐mild and 2.5% moderate. Findings showed increased impairments in swallowing efficiency and the oral phase.
Claudia Raines, Makenna Clark, Cara Donohue   +2 more
wiley   +1 more source

De Novo Mutations in PDE10A Cause Childhood-Onset Chorea with Bilateral Striatal Lesions. [PDF]

, 2016
Chorea is a hyperkinetic movement disorder resulting from dysfunction of striatal medium spiny neurons (MSNs), which form the main output projections from the basal ganglia.
Adams, ME, Balint, B, Barzaghi, C, Bhatia, KP, Carecchio, M, Davies, CH, Garavaglia, B, Giunti, P, Hardy, J, Houlden, H, Hughes, D, Kamsteeg, E-J, Kimura, H, Kurian, MA, Lynch, DS, Mencacci, NE, Meyer, E, Nakashima, K, Nardocci, N, Ng, J, Pittman, AM, R'Bibo, L, Raymond, FL, Salpietro, V, Suzuki, K, Veneziano, L, Vissers, LELM, Wiethoff, S, Willemsen, MAAP, Wood, NW, Zorzi, G   +30 more
core   +4 more sources