Results 81 to 90 of about 23,522 (208)
Distinct Brain Drivers and Shared Cerebello–Cortical Input in ADCY5 and SGCE Hyperkinetic Movements
Movement Disorders, EarlyView.Resting‐state fMRI and effective connectivity revealed distinct cerebellar–basal ganglia–cortical interactions in ADCY5 (MxMD‐ADCY5) and SGCE (MYC/DYT‐SGCE) related movement disorders. The cerebellum modulated cortex directly in MYC/DYT‐SGCE, but indirectly via basal ganglia‐cerebellar projections in MxMD‐ADCY5, which also showed reduced subthalamic ...
Clément Tarrano +33 more
wiley +1 more source
Systematic Review of the Huntington's Disease Drug Development Pipeline, 2014 to 2025
Movement Disorders, EarlyView.Abstract Background In the past decade, significant advances have improved our understanding of the mechanisms underlying HD pathobiology leading to several putative therapeutic targets for HD. Objective The aim was to describe the Huntington's disease (HD) drug development clinical pipeline.
Pavlina Konstantinova +5 more
wiley +1 more source
A Gap Analysis of Deep Brain Stimulation for Childhood‐Onset Movement Disorders
Movement Disorders, EarlyView.Abstract Background Deep brain stimulation (DBS) is an established and increasingly utilized therapy for childhood‐onset movement disorders. However, pediatric DBS poses unique challenges that are not adequately addressed by adult‐derived paradigms. Objective To identify key gaps in the current use of DBS in childhood‐onset movement disorders and to ...
Daniela Munoz‐Chesta +6 more
wiley +1 more source
Movement Disorders, EarlyView.Abstract Background Although not confirmed, some studies have suggested that elevated homocysteine levels are common in patients with Huntington's disease (HD). Its clinical relevance remains unclear. Objectives We aimed to assess vitamin B and homocysteine levels in HD patients and explore the relationships among hyperhomocysteinemia, vitamin B ...
Salomé Puisieux +16 more
wiley +1 more source
Decoding Finely Tuned Gamma Oscillations in Chronic Deep Brain Stimulation for Parkinson's Disease
Movement Disorders, EarlyView.Abstract Background Finely tuned Gamma (FTG) activity—spontaneous narrowband Gamma oscillations (sFTG) or entrained to half the stimulation frequency (eFTG)—is typically linked to on‐medication states and dyskinesia in Parkinson's disease (PD), making it a potential physiomarker for adaptive deep brain stimulation (aDBS).
Marjolein Muller +8 more
wiley +1 more source
Movement Disorders, EarlyView.Abstract Background NKX2‐1–related disorders (NKX2‐1‐RDs) classically present with a triad of neurological, endocrine, and pulmonary manifestations, including benign hereditary chorea. However, in a fraction of patients, NKX2‐1 coding variants are not detected, and variants outside the NKX2‐1 locus have been reported.
Robin Wijngaard +33 more
wiley +1 more source
Chorea as the First Sign in a Patient with Elderly-Onset Systemic Lupus Erythematosus
Case Reports in Neurological Medicine, 2012 The case of an elderly patient who had chorea as an initial symptom of systemic lupus erythematosus (SLE) accompanied by antiphospholipid syndrome (APS) is reported. A 68-year-old woman suddenly developed chorea of her left arm and leg.
Yuko Ariizumi +8 more
doaj +1 more source
Developmental Medicine &Child Neurology, EarlyView.Abstract Aim To identify the outcomes reported in published studies of intervention approaches used with non‐degenerative childhood hyperkinetic movement disorders, including dystonia, dyskinesia, hypertonia, athetosis, chorea, cerebral palsy, involuntary movement, and kernicterus, and map them to the International Classification of Functioning ...
Hortensia Gimeno +10 more
wiley +1 more source
Internal Medicine Journal, EarlyView.Abstract Background Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) are prevalent among First Nations peoples in Australia. In Western Australia (WA), notification of ARF and RHD to the WA RHD register is mandatory and supports follow‐up care.
Aung Du +6 more
wiley +1 more source