Results 91 to 100 of about 23,159 (235)

A review of xenobiotic membrane transporter expression within the human placenta: Lessons gained from primary tissue and in vitro methodologies

The Journal of Physiology, EarlyView.
Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass, Kathryn Wolton, Amanda N. Sferruzzi‐Perri   +2 more
wiley   +1 more source

Gemcitabine, Docetaxel, Melphalan, Carboplatin as Part of Sequential Cycles of High‐Dose Chemotherapy With Autologous Hematopoietic Stem‐Cell Rescue for Multiply Relapsed/Refractory Pediatric Germ Cell Tumors

Pediatric Blood &Cancer, Volume 73, Issue 6, June 2026.
ABSTRACT Although most malignant germ cell tumors (GCTs) are highly curable with cisplatin‐based therapy, options for patients with multiply relapsed/refractory disease remain limited. For this population, we report the first pediatric use of gemcitabine, docetaxel, melphalan, and carboplatin (GemDMC) as part of sequential cycles of high‐dose ...
Maria Frost, Olayinka Okeleji, Amr Elgehiny, Douglas Harrison, Cynthia Herzog, Jeremy Connors, Demetrios Petropoulos, Priti Tewari, Dristhi Ragoonanan, Yago Nieto, Irtiza N. Sheikh   +10 more
wiley   +1 more source

Oncofetal Biology: From Fundamental Mechanisms to Emerging Therapeutic Opportunities

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oncofetal biology provides a transformative framework for understanding cancer initiation, progression, and therapeutic intervention. This review synthesizes the core molecular mechanisms connecting embryonic development and tumorigenesis from a multidisciplinary standpoint and outlines future research trajectories and clinical applications, and we aim
Yang Liu, Kaifeng Niu, Qingran Kong, Shaorong Gao   +3 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, Volume 20, Issue 5, Page 1347-1363, May 2026.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Genetic Characterization and Multidisciplinary Management of Complete Androgen Insensitivity Syndrome: Unveiling a Novel AR Mutation

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT A novel AR frameshift mutation (c.2023_2035del) was identified in a 17‐year‐old phenotypic female with Complete Androgen Insensitivity Syndrome (CAIS). This report emphasizes the necessity of molecular characterization and multidisciplinary management to address diagnosis, surgical timing, and psychological well‐being in disorder of sex ...
Astorino Maria Francesca, Scalise Serena, Di Bella Chiara, La Rosa Maria Angela, Piraino Basilia, Calabrò Marco, Gentile Mattia, Ruggeri Rosaria Maddalena, Esposito Emanuela, Briuglia Silvana, Cannavò Salvatore   +10 more
wiley   +1 more source

A pure nongestational choriocarcinoma of the ovary

Journal of Research in Medical Sciences, 2007
<p style="text-align: justify" class="MsoNormal">Choriocarcinoma arises in the ovary from gestational or nongestational origin. Nongestational choriocarcinoma of the ovary is extremely rare and the pure type is less frequent than the mixed type ...
Mohammad Ali Roghaei, Parvin Mahzuni, Faryma Rezaei   +2 more
doaj  

Hypermethylation of SOX2 gene in hydatidiform mole and choriocarcinoma [PDF]

, 2008
This study investigated the expression and methylation profiles of SOX2, a stem cell-related transcription factor, in placentas and gestational trophoblastic disease.
Chan, KYK, Cheung, ANY, Li, ASM, Ngan, HYS, Siu, MKY, Wong, ESY, Zhang, H   +6 more
core   +1 more source

A Rare Case of Primary Pulmonary Choriocarcinoma Metastasizing to the Kidney: Diagnostic and Therapeutic Complexities

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Choriocarcinoma is a highly aggressive malignant tumor composed primarily of cytotrophoblast and syncytiotrophoblast cells without villi and is characterized by beta‐human chorionic (beta‐hCG) gonadotropin production. Although most cases are of gestational origin, rare non‐gestational choriocarcinomas may arise from pluripotent germ
Zorán Belics, Antónia Fürich, Levente Bogyó, Hanna Tihanyi, Mária Madarász, Dorottya Rózsa, Gizella Molnár, Balázs Gérecz, Petronella Hupuczi   +8 more
wiley   +1 more source

Choriocarcinoma of the breast; A case report and review of literatures

Journal of Research in Medical Sciences, 2011
Choriocarcinoma is an extremely rare pathology among breast malignancies. It is introduced by two distinct terms in the literatures: breast cancer with choriocarcinomatous features and metastatic choriocarcinoma to the breast.
Simin Hemati, Omid Esnaashari, Mohamadreza Mohajeri, Mostafa Sarvizadeh   +3 more
doaj  

Spontaneous acute subdural hematoma as an initial presentation of choriocarcinoma: A case report

Journal of Medical Case Reports, 2008
Introduction Diverse sequelae of central nervous system metastasis of choriocarcinoma have been reported, including infarction, intra or extra axial hemorrhages, aneurysm formation and carotid-cavernous fistula. Here we report a case of subdural hematoma
Rocque Brandon G, Başkaya Mustafa K
doaj   +1 more source