Results 11 to 20 of about 22,213 (195)

Drug library screening identifies histone deacetylase inhibition as a novel therapeutic strategy for choriocarcinoma

Cancer Medicine, 2023
Background Choriocarcinoma is a rare and aggressive gynecological malignancy. The standard treatment is systemic chemotherapy as choriocarcinoma exhibits high chemosensitivity.
Eri Watanabe, Akira Yokoi, Kosuke Yoshida, Mai Sugiyama, Masami Kitagawa, Kimihiro Nishino, Eiko Yamamoto, Kaoru Niimi, Yusuke Yamamoto, Hiroaki Kajiyama   +9 more
doaj   +2 more sources

Intestinal metastasis from choriocarcinoma: a case series and literature review

World Journal of Surgical Oncology, 2022
Background Gestational choriocarcinoma is a rare trophoblastic tumor that spreads mainly to the lung, liver, and central nervous system. Fewer than 5% of patients present with metastasis to the gastrointestinal system and have a poor prognosis Case ...
Yuting Wang, Zhe Wang, Xiaoxu Zhu, Qihong Wan, Peilin Han, Jun Ying, Jianhua Qian   +6 more
doaj   +2 more sources

miR-497-5p/SALL4 axis promotes stemness phenotype of choriocarcinoma and forms a feedback loop with DNMT-mediated epigenetic regulation

Cell Death and Disease, 2021
Choriocarcinoma stem-like cells (CSLCs) might be at the origin of choriocarcinoma development associated with drug resistance or relapse. Spalt-like transcription factor 4 (SALL4), which is considered to be a stemness-related gene, can be regulated by ...
Zheng Peng, Yi Zhang, D. Shi, Yanyan Jia, Huirong Shi, Huining Liu   +5 more
semanticscholar   +1 more source

α-Solanine Inhibits Proliferation, Invasion, and Migration, and Induces Apoptosis in Human Choriocarcinoma JEG-3 Cells In Vitro and In Vivo

Toxins, 2021
α-Solanine, a bioactive compound mainly found in potato, exhibits anti-cancer activity towards multiple cancer cells. However, its effects on human choriocarcinoma have not been evaluated. In the present study, we investigated the effect of α-solanine on
T. Gu, W. Yuan, Chen Li, Zhilong Chen, Yuting Wen, Qiyi Zheng, Qing Yang, Xingyao Xiong, Anwen Yuan   +8 more
semanticscholar   +1 more source

Nucleoside transporter-guided cytarabine-conjugated liposomes for intracellular methotrexate delivery and cooperative choriocarcinoma therapy

Journal of Nanobiotechnology, 2021
Gestational trophoblastic tumors seriously endanger child productive needs and the health of women in childbearing age. Nanodrug-based therapy mediated by transporters provides a novel strategy for the treatment of trophoblastic tumors.
Weidong Fei, Yunchun Zhao, Xiaodong Wu, Dong-li Sun, Yao Yao, Fengmei Wang, Meng Zhang, Chaoqun Li, Jiale Qin, Caihong Zheng   +9 more
semanticscholar   +1 more source

A Rare Case of Non-Gestational Metastatic Ovarian Choriocarcinoma: Case Report and Literature Review With a Special Emphasis on Imaging

Cureus, 2021
Non-gestational choriocarcinoma of the ovary is a very rare neoplasm. It carries a worse prognosis as compared to gestational choriocarcinoma (GCC). Here, we report a case of non-gestational ovarian choriocarcinoma.
Abdul Sattar Anjum, H. Maqsood, Shifa Younus, Sadia Anjum, Maham Fatima   +4 more
semanticscholar   +1 more source

Transcriptomic Characterization of Postmolar Gestational Choriocarcinoma

Biomedicines, 2021
The human placenta shares properties with solid tumors, such as rapid growth, tissue invasion, cell migration, angiogenesis, and immune evasion. However, the mechanisms that drive the evolution from premalignant proliferative placental diseases—called ...
Constance Collet, Jonathan Lopez, Christophe Battail, Fabienne Allias, Mojgan Devouassoux-Shisheboran, Sophie Patrier, Nicolas Lemaitre, Touria Hajri, Jérôme Massardier, Benoit You, François Mallet, François Golfier, Nadia Alfaidy, Pierre-Adrien Bolze   +13 more
doaj   +1 more source

Vulva choriocarcinoma

Pan African Medical Journal, 2016
Choriocarcinoma vulva is an exceptional location of gestational trophoblastic tumors. We report the case of a female patient of 23 years who had vulvar mass, painful, sitting at the large right lip and measured five centimeters in diameter. Pelvic ultrasound was normal. Beta-h-CG (human chorionic gonadotrophin) quantitative plasma were highly increased.
Houssine Boufettal, Naema Samouh
openaire   +6 more sources

Postmolar choriocarcinoma after an interval of 7 years: Case report and literature review

Gynecology and Minimally Invasive Therapy, 2017
Choriocarcinoma is a rare pregnancy-related malignancy. The majority is arising from non-molar pregnancy. Here we report a patient who was diagnosed with postmolar choriocarcinoma after an interval of 7 years.
Min-Min Hou, Lian Xu, Ming-Rong Qie
doaj   +1 more source

Infantile and Maternal Choriocarcinoma: A Case Report and Review of Literature [PDF]

Iranian Journal of Neonatology, 2016
Background: Choriocarcinoma is a rare highly malignant trophoblastic neoplasm. It can be preceded by any form of gestation including a complete or a partial mole, miscarriage and normal pregnancy.
Ziba Mosayebi, Amir hosein Movahedian, Iran Malekzadeh   +2 more
doaj   +1 more source