Results 21 to 30 of about 69 (67)

Germ cell and other tumors in individuals with differences in sex development

CA: A Cancer Journal for Clinicians, EarlyView.
Abstract Approximately one in 3500 to one in 5100 live‐born infants have atypical external genital development, known as differences in sex development (DSD). In 2005, an expert consensus conference thoroughly reviewed aspects of health care for individuals with DSD.
Selma Feldman Witchel, Miguel Reyes‐Múgica   +1 more
wiley   +1 more source

Induction of SOX17 with stimulation of WNT, TGF‐beta, and FGF signaling drives embryonal carcinomas into the yolk‐sac tumor lineage resulting in increased cisplatin resistance

International Journal of Cancer, Volume 156, Issue 11, Page 2210-2224, 1 June 2025.
What's new? Yolk‐sac tumor formation has been suggested to be an escape mechanism during therapy in patients with relapsing germ cell tumors. The molecular mechanisms inducing yolk‐sac tumor development from stem cell‐like precursor embryonal carcinomas remain unclear.
Mara Kotthoff, Margaretha A. Skowron, Felix Bremmer, Fatma Parmaksiz, Pia Kretschmer, Alexa Stephan, Alexander Fichtner, Tobias Lautwein, Katharina Raba, Janina Fuß, Karl Köhrer, Daniel Nettersheim   +11 more
wiley   +1 more source

MicroRNA‐371–373 cluster and methylome analysis suggests that a subset of ‘somatic‐type’ malignancies arising in germ cell tumors may originate in yolk sac tumor components

The Journal of Pathology, Volume 266, Issue 2, Page 160-176, June 2025.
Abstract Somatic‐type malignancies (SMs) arising in germ cell tumors (GCTs) are aggressive neoplasms resistant to systemic treatment. Most are diagnosed in metastatic sites after chemotherapy; however, they have also been well‐documented in primary testicular GCTs.
João Lobo, Nuno Tiago Tavares, Diana Fonseca, Carmen Jerónimo, Rui Henrique, Nicolas Wyvekens, Yiying Yang, Matija Snuderl, Fiona Maclean, Jennifer Gordetsky, Christopher DM Fletcher, Michelle S Hirsch, Jason L Hornick, Muhammad T Idrees, Katrina Collins, Laura Warmke, Thomas M Ulbright, Andres M Acosta   +17 more
wiley   +1 more source

Gastrointestinal Bleeding due to Small Intestinal Metastases From Choriocarcinoma

United European Gastroenterology Journal, EarlyView.
Huipeng Zhang, Jing Zhang, Yanbo Yu, Xin Long   +3 more
wiley   +1 more source

Enhancing the utility of placental pathology reports for clinical use

Pregnancy, Volume 1, Issue 3, May 2025.
Abstract Obstetric training programs typically offer limited formal education on placental pathology; yet, in practice, obstetric providers are expected to incorporate placental pathology findings into the overall evaluation of obstetric complications.
Janelle Santos, Linda M. Szymanski, Regan N. Theiler, Andrew P. Norgan, Elizabeth Ann L. Enninga, Molly Mcduffie, Lainee A. Bulawa‐Regner, E. Heidi Cheek‐Norgan, Julie A. Lamppa, Myra Wick   +9 more
wiley   +1 more source

Primary choriocarcinoma of the vulva

International Journal of Gynecological Cancer, 2001
Primary extrauterine choriocarcinoma is very rare, found mostly in the genital tract (tube, cervix, ovary, vagina). Other sites such as lungs, gastrointestinal tract, heart, brain and submentum also have been reported. A 31-year-old woman presented with abnormal uterine bleeding 6 weeks after her last menstrual cycle. Her HCG titer level was 900 mIu/ml.
Alan L. Kaplan, S. Weiss, Amnon Amit, Mary R. Schwartz   +3 more
openaire   +3 more sources

A Comprehensive Review on LncRNAs/miRNAs‐DNMT1 Axis in Human Cancer: Mechanistic and Clinical Application

Journal of Cellular and Molecular Medicine, Volume 29, Issue 10, May 2025.
ABSTRACT Cancer constitutes a significant public health concern, and addressing the challenge of cancer holds paramount importance and requires immediate attention. Epigenetic alterations, encompassing DNA methylation, have emerged as pivotal contributors to the development of diverse cancer types.
Seyed Mohsen Aghaei‐Zarch, Ali Esmaeili, Saeid Bagheri‐Mohammadi   +2 more
wiley   +1 more source

Replenishing co‐downregulated miR‐100‐5p and miR‐125b‐5p in malignant germ cell tumors causes growth inhibition through cell cycle disruption

Molecular Oncology, Volume 19, Issue 4, Page 1203-1228, April 2025.
MiR‐99a‐5p/miR‐100‐5p (functionally identical) and miR‐125b‐5p microRNAs are downregulated in malignant germ cell tumors (GCTs). Combination replenishment of these microRNAs using mimics resulted in growth inhibition in representative cell lines, with consequent downregulation of target genes involved in cell cycle (confirmed by flow cytometry) and ...
Marta Ferraresso, Shivani Bailey, Luz Alonso‐Crisostomo, Dawn Ward, Christos Panayi, Zachary G. L. Scurlock, Harpreet K. Saini, Stephen P. Smith, James C. Nicholson, Anton J. Enright, Cinzia G. Scarpini, Nicholas Coleman, Matthew J. Murray   +12 more
wiley   +1 more source

MicroRNAs in seminal plasma are able to discern infertile men at increased risk of developing testicular cancer

Molecular Oncology, Volume 19, Issue 4, Page 1188-1202, April 2025.
Male infertility is a known risk factor for the development of testicular cancer. In this paper, we analyzed the expression profile of a microRNA panel by real‐time PCR and validated the results by digital PCR. Experimental and bioinformatics analyses allowed us to identify possible biomarkers able to discern men with a higher risk of developing ...
Carmen Ferrara, Rosalia Battaglia, Angela Caponnetto, Anna Fazzio, Michele Stella, Cristina Barbagallo, Nicolò Musso, Federica Lunelio, Maria Elena Vento, Placido Borzì, Paolo Scollo, Davide Barbagallo, Marco Ragusa, Salvatore Pernagallo, Cinzia Di Pietro   +14 more
wiley   +1 more source

Multiple intracranial hemorrhages in a postmenopausal female

Brain Pathology, EarlyView.
Xinhua Lu, Xinya Xu, Xiaopeng Zhang
wiley   +1 more source