Results 21 to 30 of about 76,034 (343)
Variants of human chorionic gonadotropin from pregnant women and tumor patients recognized by monoclonal antibodies [PDF]
, 1993 In biological fluids, hCG and its free alpha- (hCG alpha) and beta-subunits (hCG beta), occur in multiple forms. These various forms differ at the molecular level primarily in glycosylation, but also differ in protein backbone modifications corresponding
Berger, Peter +4 more
core +1 more source
Interaction of Human Chorionic Gonadotropin (hCG) and Asialo-hCG with Recombinant Human Thyrotropin Receptor. [PDF]
, 1994 hCG is a putative thyroid stimulator. The present studies were undertaken to examine its interaction and that of its desialylated variant asialo-hCG with recombinant human TSH (hTSH) receptor (hTSHr). To this end, we transfected a human thyroid carcinoma
Broecker, M. +4 more
core +1 more source
Human Luteinizing Hormone and Chorionic Gonadotropin Display Biased Agonism at the LH and LH/CG Receptors [PDF]
Scientific Reports, 7(940) (2017), 2018 Human luteinizing hormone (LH) and chorionic gonadotropin (hCG) have been considered biologically equivalent because of their structural similarities and their binding to the same receptor; the LH/CGR. However, accumulating evidence suggest that LH/CGR differentially responds to the two hormones triggering differential intracellular signaling and ...
arxiv +1 more source
Extragonadal LH/hCG action-Not yet time to rewrite textbooks [PDF]
, 2007 Gonadotropins are indispensable in both sexes in the regulation of gonadal sex steroid production and gametogenesis. In addition to their well-established classical actions, numerous recent publications have indicated the presence and function of ...
Ahtiainen, Petteri +5 more
core +3 more sources
Journal of Medical Case Reports, 2020 Background Ovarian hyperstimulation syndrome is normally induced by ovarian stimulation drugs. Severe cases of ovarian hyperstimulation syndrome involve complications such as renal failure and thrombosis. Evidence has recently been developed for a method
Haipeng Huang +11 more
doaj +1 more source
Journal of Medicine in Scientific Research, 2020 Human chorionic gonadotropin (hCG) is a human pregnancy hormone that plays a crucial role in the promotion, maintenance, and establishment of pregnancy. Measurement of hCG in early pregnancy is the first and most common test.
Falah H.O Al-Khikani, Bashar J Kadem
doaj +1 more source
Profiling of FSHR Negative Allosteric Modulators on LH/CGR Reveals Biased Antagonism with Implications in Steroidogenesis [PDF]
Molecular and Cellular Endocrinology, 436:10--22 (2016), 2018 Biased signaling has recently emerged as an interesting mean to modulate the function of many G protein-coupled receptors (GPCRs). Previous studies reported two negative allosteric modulators (NAMs) of follicle-stimulating hormone receptor (FSHR), ADX68692 and ADX68693, with differential effects on FSHR-mediated steroidogenesis and ovulation.
arxiv +1 more source
Extragonadal actions of chorionic gonadotropin [PDF]
Reviews in Endocrine and Metabolic Disorders, 2011 The primary embryonic signal in primates is chorionic gonadotropin (CG, designated hCG in humans), that is classically associated with corpus luteum rescue and progesterone production. However, research over the past decade has revealed the presence of the hCG receptor in a variety of extragonadal tissues.
Prajna Banerjee, Asgerally T. Fazleabas
openaire +3 more sources
Advances in computational modeling approaches in pituitary gonadotropin signaling [PDF]
Expert Opinion on Drug Discovery, 1-15. (2018), 2018 Pituitary gonadotropins play an essential and pivotal role in the control of human and animal reproduction within the hypothalamic-pituitary-gonadal (HPG) axis. The computational modeling of pituitary gonadotropin signaling encompasses phenomena of different natures such as the dynamic encoding of gonadotropin secretion, and the intracellular cascades ...
arxiv +1 more source
First-trimester combined screening for trisomy 21 at 7-14 weeks' gestation. [PDF]
, 2010 OBJECTIVE: To establish an algorithm for first-trimester combined screening for trisomy 21 with biochemical testing from 7 to 14 weeks' gestation and ultrasound testing at 11-13 weeks. METHODS: This was a multicenter study of 886 pregnancies with trisomy
Borrell +11 more
core +1 more source