Results 41 to 50 of about 5,473 (268)

Prenatal diagnosis of hemoglobinopathies: from fetoscopy to coelocentesis

Thalassemia Reports, 2014
Prenatal diagnosis of hemoglobinopathies involves the study of fetal material from blood, amniocytes, trophoblast coelomatic cells and fetal DNA in maternal circulation.
Gianfranca Damiani, Margherita Vinciguerra, Cristina Jakil, Monica Cannata, Filippo Cassarà, Francesco Picciotto, Giovanna Schillaci, Valentina Cigna, Disma Renda, Aldo Volpes, Francesca Sammartano, Samuela Milone, Adolfo Allegra, Cristina Passarello, Filippo Leto, Antonino Giambona   +15 more
doaj   +1 more source

Optimal villi density for maximal oxygen uptake in the human placenta

, 2015
We present a stream-tube model of oxygen exchange inside a human placenta functional unit (a placentone). The effect of villi density on oxygen transfer efficiency is assessed by numerically solving the diffusion-convection equation in a 2D+1D geometry ...
Brownbill, P., Filoche, M., Grebenkov, D. S., Salafia, C., Serov, A. S.   +4 more
core   +1 more source

Prenatal Identification of a Novel Mutation in the MCPH1 Gene Associated with Autosomal Recessive Primary Microcephaly (MCPH) Using Next Generation Sequencing (NGS): A Case Report and Review of the Literature

Children, 2022
Background: MCPH1 is known as the microcephalin gene (OMIM: *607117), of which the encoding protein is a basic regulator of chromosome condensation (BCRT-BRCA1 C-terminus).
Ioannis Papoulidis, Makarios Eleftheriades, Emmanouil Manolakos, Michael B. Petersen, Simoni Marina Liappi, Anastasia Konstantinidou, Maria Papamichail, Vassilios Papadopoulos, Antonios Garas, Sotirios Sotiriou, Ioannis Papastefanou, Georgios Daskalakis, Aleksandar Ristic   +12 more
doaj   +1 more source

Chorionic Structures in Maternal Blood [PDF]

, 2007
Chorionic villi are the exchange structures of the placenta where human fetuses receive oxygen and nutrients from maternal blood, this article reports an improvement of a published method to recover them from the blood of pregnant, women, quotes their ...
Nilo Pereira Luz
core   +1 more source

Risk of preeclampsia in of women who underwent chorionic villus sampling [PDF]

, 2018
OBJECTIVE: To assess the risk of preeclampsia in women who underwent chorionic villus sampling (CVS). STUDY DESIGN: This is a retrospective, single-center, cohort study.
Berghella, Vincenzo, Castaldo, Giuseppe, Giudicepietro, Antonia, Martinelli, Pasquale, Maruotti, Giuseppe Maria, Saccone, Gabriele, Sarno, Laura, Zullo, Fulvio   +7 more
core   +1 more source

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

A lesson for cancer research : placental microarray gene analysis in preeclampsia [PDF]

, 2012
Tumor progression and pregnancy share many common features, such as immune tolerance and invasion. The invasion of trophoblasts in the placenta into the uterine wall is essential for fetal development, and is thus precisely regulated.
Louwen, Frank, Muschol-Steinmetz, Cornelia, Reinhard, Joscha, Reitter, Anke, Yuan, Juping   +4 more
core   +2 more sources

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, EarlyView.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

Placental Structure in Preterm Birth Among HIV-Positive Versus HIV-Negative Women in Kenya. [PDF]

, 2019
BackgroundPreterm birth (PTB) is a major cause of infant morbidity and mortality in developing countries. Recent data suggest that in addition to Human Immunodeficiency Virus (HIV) infection, use of antiretroviral therapy (ART) increases the risk of PTB.
Cohen, Craig R, Fisher, Susan J, McMaster, Michael T, Obimbo, Moses M, Ogeng'o, Julius A, Ong'ech, John, Qureshi, Zahida, Zhou, Yan   +7 more
core  

Gene expression of stem cells at different stages of ontological human development [PDF]

, 2013
Objectives To compare multipotent mesenchymal stem cells (MSCs) obtained from chorionic villi (CV), amniotic fluid (AF) and placenta, with regard to their phenotype and gene expression, in order to understand if MSCs derived from different extra ...
Allegra, A, ALTOMARE, Roberta, Curcio, P, LO MONTE, Attilio Ignazio, Marino, A., Mazzola, S, Santoro, A   +6 more
core   +1 more source