Results 171 to 180 of about 79,402 (255)

Long‐term follow‐up of chronic central serous chorioretinopathy patients receiving oral eplerenone and half‐dose photodynamic therapy in the SPECTRA trial: SPECTRA trial report No. 4

Acta Ophthalmologica, Volume 104, Issue 5, Page e565-e577, August 2026.
Abstract Purpose Assessing the 24‐month treatment outcome of half‐dose photodynamic therapy (PDT) or oral eplerenone in chronic central serous chorioretinopathy (cCSC). Methods Multicentre randomized clinical trial included cCSC patients from the SPECTRA trial who were randomized to receive half‐dose PDT or oral eplerenone.
Helena M. A. Feenstra, Issam El Mansori, Thomas J. van Rijssen, Roula Tsonaka, Roselie M. H. Diederen, Carel B. Hoyng, Reinier O. Schlingemann, Camiel J. F. Boon, Elon H. C. van Dijk   +8 more
wiley   +1 more source

Choroid Plexus Cyst with Parenchymal Localization in a Symptomatic 50-year-old Male: A Case Report. [PDF]

NMC Case Rep J
Ayhan B, Semiz HÖ, Kamar Z, Yalçin ÜK, Ersöz TAA.   +4 more
europepmc   +1 more source

Levetiracetam inhibits the Na+ HCO3− transporter Ncbe/NBCn2 (Slc4a10) in the choroid plexus of mice

Acta Physiologica, Volume 242, Issue 8, August 2026.
ABSTRACT Aim The Na+‐dependent Cl−/HCO3− exchanger Ncbe/NBCn2 (Slc4a10) constitutes a major basolateral HCO3− uptake pathway in the choroid plexus and contributes to cerebrospinal fluid secretion and pH regulation. This study examined whether levetiracetam inhibits Ncbe/NBCn2‐mediated transport and alters cerebrospinal fluid acid–base balance ...
Laura Øllegaard Johnsen, Lasse Messell Desdorf, Nicoline Stærke Jensen, Jeppe Praetorius, Helle Hasager Damkier   +4 more
wiley   +1 more source

Longitudinal changes of choroid plexus volumes and MRI ratios in multiple sclerosis. [PDF]

Brain Commun
Krieger B, Bellenberg B, Müller D, Sbaihat H, Roenneke AK, Ladopoulos T, Schneider R, Gold R, Lukas C.   +8 more
europepmc   +1 more source

Multi‐Omics Integration Reveals That SN‐011 Targets JUNB to Upregulate ADGRE5 and Restore Vascular Endothelial Cell Communication in Ischemic Stroke

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
Ischemic stroke (IS) remains a leading cause of disability with limited therapeutic targets. Using multi‐omics integration, we identified ADGRE5 as a protective gene significantly downregulated in venous endothelial cells (vECs) during IS. JUNB acts as a key upstream transcription factor that negatively regulates ADGRE5 expression.
XiangLing Ou, ZunKe Gong
wiley   +1 more source

Selected Retinal and Choroidal Parameters Assessed by Optical Coherence Tomography and Optical Coherence Tomography Angiography in Patients With Obstructive Sleep Apnea. [PDF]

Med Sci Monit
Szabelska P, Białas D, Mianowany M, Kukwa W, Radzikowska J, Różycki R, Gołębiewska J.   +6 more
europepmc   +1 more source

Human Pharmacokinetic Prediction of Antibody‐Drug Conjugates Using Human FcRn Transgenic Mice

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT Antibody‐drug conjugates (ADCs) have progressed significantly in recent years, particularly in the oncology field. However, predicting human pharmacokinetics (PK) of ADCs in the early stages of drug development remains challenging. Human neonatal Fc receptor (FcRn) transgenic mice have been established as a reliable pre‐clinical PK model for ...
Keitaro Nakagawa, Kenta Haraya
wiley   +1 more source

Purtscher-like retinopathy associated with COVID-19: a case report [PDF]

International Journal of Ophthalmology
Wen-Bo Liu, Yi Cai, Miao Zhou, Hashimoto Kinji, Ming-Wei Zhao, Xuan Shi   +5 more
doaj   +1 more source

Identification of COL4A2 as a Biomarker of Extracellular Matrix Remodeling and Vascular Scaffold in Choroid for Myopia. [PDF]

Invest Ophthalmol Vis Sci
Chen B, Xu Y, Xie S, Zhou X, Wang L, Yuan C, Ni Y, Zhang Z.   +7 more
europepmc   +1 more source

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, Volume 293, Issue 15, Page 4680-4703, August 2026.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source