Results 71 to 80 of about 6,086 (202)
Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma. [PDF]
, 2017 Uveal melanoma is the most common primary intraocular malignant tumor in adults and arises from the transformation of melanocytes in the uveal tract. Even after treatment of the primary tumor, up to 50% of patients succumb to metastatic disease.
Aplin, Andrew E. +5 more
core +1 more source
BMEMat, Volume 4, Issue 1, March 2026.Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen +7 more
wiley +1 more source
Regression of choroidal metastasis from breast carcinoma with palbociclib
International Journal of Retina and Vitreous, 2022 Background Uveal metastasis is reported to be the most common intraocular malignancy. The most common site of origin of ocular metastases in females is the breast. In some cases, uveal metastatic lesions respond to systemic chemotherapy. We report a case
Shweta Parakh +5 more
doaj +1 more source
Treatment of choroid metastases
The British Journal of Radiology, 1988 Abstract Sixteen patients with choroid secondary tumours were treated with irradiation consisting of 40–50 Gy in 3–5 weeks. There were 14 female patients with breast cancer, one male patient with prostatic cancer and one male patient with cancer of unknown origin. In four cases bilateral ocular metastases were seen. Ten out of 20 treated
openaire +2 more sources
Cochrane Evidence Synthesis and Methods, Volume 4, Issue 2, March 2026.ABSTRACT Introduction Social determinants of health (SDOH), including economic stability, education access and quality, healthcare access and quality, neighborhood and built environment, and social and community context, shape gaps in health outcomes across many conditions. Ocular neoplasms are no exception. Cancers such as uveal melanoma, conjunctival
Daniel Shaughnessy +7 more
wiley +1 more source
Medicina, 2021 The efficacy of combined intravitreal bevacizumab injection with systemic chemotherapy, palliative radiotherapy, and hormonal therapy to treat choroidal and orbital metastases is not known.
I-Hung Lin, Bo-I Kuo, Fang-Yu Liu
doaj +1 more source
The Eye Never Lies: When A Lesion Unveils Lung Cancer
Respirology Case Reports, Volume 14, Issue 3, March 2026.We present a rare case of asymptomatic primary lung adenocarcinoma that first manifested with ocular symptoms and an iris lesion. ABSTRACT Ocular manifestations rarely represent the first sign of systemic malignancy and often pose a diagnostic challenge. While choroidal metastases are more common, iris involvement is uncommon and may be underrecognized.
Sivanesan Darshini +5 more
wiley +1 more source
Metastatic potential of small posterior uveal melanomas
Acta Ophthalmologica, Volume 104, Issue 2, Page e191-e203, March 2026.Abstract Purpose To investigate the prevalence of aggressive traits in small posterior uveal melanomas (UM). Methods This retrospective, multicentre cohort study included 804 patients with small posterior UM (≤9 mm in largest basal diameter, ≤3 mm in thickness) from centres in the UK, Germany, and Sweden.
Gustav Stålhammar +9 more
wiley +1 more source
Choroidal Metastasis of Adenocarcinoma of the Lung Presenting as Pigmented Choroidal Tumor
Case Reports in Ophthalmology, 2012 Our case represents a unique occurrence of pigmented choroidal tumor that clinically appeared as choroidal melanoma and was treated accordingly. At the same time, while evaluating the patient for systemic metastases of uveal melanoma, she was diagnosed ...
Shahar Frenkel, Jacob Pe’er
doaj +1 more source
American Journal of Ophthalmology Case Reports, 2020 Purpose: Nuclear medicine imaging can provide a noninvasive means of distinguishing inflammatory mass lesions from oncologic intraocular tumors. Observation: We report a case of paraneoplastic ocular sarcoidosis with choroidal mass lesions that was ...
Elizabeth D. Marlow, M.D. +4 more
doaj +1 more source