Results 71 to 80 of about 60,075 (222)

Inhibition of VEGF‐Induced Angiogenesis and Vascular Leakage by Bicistronic Co‐Expression of Aflibercept and COMP‐Ang1

Advanced Healthcare Materials, Volume 15, Issue 35, 18 September 2026.
A bicistronic rAAV8 vector encoding Aflibercept (Afb) and COMP‐cAng1 simultaneously coordinates VEGF clearance and Tie2‐mediated vessel maturation. In a 3D angiogenesis‐on‐a‐chip model, rAAV8‐Afb/cAng1 effectively reverses pathological barrier breakdown under clinical disease‐mimicking challenges.
Bong‐Kyu Kim, Jaehong Min, Sang‐Hee Park, Subeen Shin, Sangbin Yu, Jeong‐Eun Park, Sujin Kim, Wooju Park, Jihoon Ko, Sunjong Kwon   +9 more
wiley   +1 more source

Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

Advanced Science, Volume 13, Issue 52, 18 September 2026.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui, Lulu Qian, Binbin Chu, Xuan Qin, Menglin Wu, Minke Wu, Tongyu He, Baochuan Zhang, Bin Song, Yao He   +9 more
wiley   +1 more source

Spontaneous transition of focal choroidal excavation from a nonconforming to a conforming form: Unusual clinical presentation

Indian Journal of Ophthalmology. Case Reports
Focal choroidal excavation (FCE) represents a macular choroidal concavity. It is categorized as conforming and nonconforming, and may be associated with complications such as choroidal neovascularization.
Karol Quintero Lizcano, Juan Manuel Correa Alvarez, Sarita Restrepo Velásquez, Mauricio Arango Hurtado   +3 more
doaj   +1 more source

Intravitreal Ranibizumab for the Treatment of Choroidal Neovascularization Secondary to Endogenous Endophthalmitis

Kaohsiung Journal of Medical Sciences, 2009
Choroidal neovascularization is a major cause of visual loss in age-related macular degeneration. It is also a potential vision-threatening complication of pathologic myopia, uveitis, traumatic choroidal rupture and, rarely, endophthalmitis.
Shwu-Jiuan Sheu
doaj   +1 more source

Choroidal neovascular membrane.

Indian journal of ophthalmology, 1998
Choroidal neovascular membrane in the macular area is one of the leading causes of severe visual loss. Usually a manifestation in elderly population, it is often associated with age-related macular degeneration. The current mainstay of management is early diagnosis, usually by fundus examination, aided by angiography and photocoagulation in selected ...
Bhatt Nitul, Diamond James, Jalali Subhadra, Das Taraprasad   +3 more
openaire   +2 more sources

FOXO6 inhibits SMURF2‐mediated ubiquitination and degradation of NR4A1 to promote retinal pigment epithelial cell ferroptosis in diabetic retinopathy

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
FOXO6 suppresses the transcriptional expression of SMURF2, thereby limiting the ubiquitination and degradation of NR4A1. Stabilized NR4A1 promotes ferroptosis in RPE cells, contributing to the progression of diabetic retinopathy. Abstract Diabetic retinopathy (DR) is the main cause of vision loss, with retinal pigment epithelial (RPE) cell dysfunction ...
Qiao Chen, Bo Su, Ke Xu, Liang Li, Changzheng Chen   +4 more
wiley   +1 more source

Multiple choroidal osteomas in a boy – a rare presentation: a case report

Journal of Medical Case Reports, 2019
Background Choroidal osteoma is rare clinical entity of unknown etiology, characterized by formation of mature cancellous bone within the choroid. It typically affects young females, with no racial predilection.
Arup Deuri, Deepanjan Ghosh, Jayant Ekka, Vijaya Agarwalla   +3 more
doaj   +1 more source

Choroidal neovascularization after cryoapplication

Albrecht von Graefes Archiv f�r Klinische und Experimentelle Ophthalmologie, 1981
After sealing peripheral retinal tears in retinal detachment surgery by means of cryoapplications, neovascularization appeared, stemming from the choroidal circulation. This complication was noted in three cases of retinal detachment with tears in an area of latticelike degeneration.
openaire   +3 more sources

Cascade‐targeted intervention of the NLRP3 inflammasome and downstream angiogenesis by curcumin nanoparticles for ocular neovascularization therapy

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Ultrasound‐microreactor synthesizes monodisperse 125 nm Cur‐NPs with enhanced solubility. Cur‐NPs suppress VEGF signaling and retinal neovascularization via the NLRP3 axis. Multi‐omics profiling reveals that Cur‐NPs reprogram retinal microglia and metabolic pathways.
Siyu Jiang, Ziwei Cheng, Yujuan Cai, Yanji Zhu, Nyamjargal Nyambayar, Ruijie Lin, Li Zhang, Jian Chen, Bing Xie, Xiuping Chen   +9 more
wiley   +1 more source

Choroidal neovascularization in Bardet-Biedl syndrome

, 2013
Purpose: To describe a case of choroidal neovascularization in a young patient with genetically-proven Bardet-Biedl syndrome. Methods: Case description with fundus and anatomical photography and optical coherence tomography. Patients: Single patient case
Fortun, Jorge, Charkoudian, Leon D, Barañano, David E, Srivastava, Sunil K, Yan, Jiong   +4 more
core   +1 more source