Results 61 to 70 of about 4,437 (235)

Effects of metformin on retinoblastoma growth in vitro and in vivo [PDF]

, 2014
Recent studies suggest that the anti-diabetic drug metformin may reduce the risk of cancer and have anti-proliferative effects for some but not all cancers. In this study, we examined the effects of metformin on human retinoblastoma cell proliferation in
BRODOWSKA, KATARZYNA, CICHY, JOANNA, GRAGOUDAS, EVANGELOS S., HOANG, MIEN, HÖRSTE, MELISSA MEYER ZU, KIERNAN, ELIZABETH, MILLER, JOAN W., PASCHALIS, ELEFTHERIOS I., RAMSEY, DAVID J., SCOTT, GORDON, TAKEUCHI, KIMIO, THEODOROPOULOU, SOFIA, VAVVAS, DEMETRIOS G.   +12 more
core   +2 more sources

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Characterization of Choriocapillaris and Choroidal Abnormalities in Alport Syndrome [PDF]

, 2022
Purpose: To analyze the characteristics of the choriocapillaris and the choroid in patients with Alport syndrome (AS) and investigate their clinical and demographic associations. Methods: Multicenter, cross-sectional study.
Aschauer C., Cicinelli M. V., Ghossein C., Gill M. K., Jampol L. M., Laccone F., Nagel M., Ritter M., Tausif H.   +8 more
core   +1 more source

Choroidal structural alterations and choroidal vascularity index in bipolar disorder patients

Photodiagnosis and Photodynamic Therapy, 2023
The aim of this study was to compare bipolar disorder (BD) patients with age- and sex-matched healthy individuals in order to assess the choroidal structural alterations, retinal nerve fiber layer (RNFL) thickness, and retinal changes in BD patients using encanhed depth imaging optic coherence tomography (EDI-OCT).For this research, 39 eyes of BD ...
Isil Merve Torun, Nejla Tukenmez Dikmen, Nergis Tellioglu Saka, Murat Sonmez   +3 more
openaire   +2 more sources

Microrobotic Catheterization of the Ophthalmic Artery for Targeted Treatment of Retinoblastoma

Advanced Intelligent Systems, EarlyView.
A microrobotic platform is presented that allows teleoperated and autonomous navigation of flow‐driven magnetic microcatheters, MagFlow, into the ophthalmic artery for superselective intra‐arterial infusion of chemotherapy to treat retinoblastoma. Extensive benchtop validations with patient‐derived biomimetic phantoms under optical and fluoroscopic ...
Artur Banach, Mehdi Krichen, Julian Raub, Christina Stathopoulos, Bruno Bartolini, Mahmut Selman Sakar   +5 more
wiley   +1 more source

Quantitative analysis of retinal and choroidal microvascular changes in patients with diabetes

Scientific Reports, 2018
The relationship between choroidal and retinal microvascular changes has not yet been well described, and there were limited data on diagnostic ability of optical coherence tomography (OCT)-derived vascular parameters for determining diabetic retinopathy
Mirinae Kim, Seung Yong Choi, Young-Hoon Park   +2 more
doaj   +1 more source

Quantitative analysis of choroidal alterations in thyroid eye disease using swept-source OCT

Frontiers in Physics, 2023
Purpose: To investigate choroidal alterations in patients with thyroid eye disease (TED) using swept-source optical coherence tomography (SS-OCT) and compare them with age-matched healthy controls.Methods: SS-OCT scans were performed to obtain ...
Yining Dai, Kailu Wang, Dongping Zheng, Guangxu Li, Guangxu Li, Kang Wang, Xin Wang, Bin Sun   +7 more
doaj   +1 more source

Current choroidal imaging findings in central serous chorioretinopathy [PDF]

, 2020
none9Background: Central serous chorioretinopathy (CSCR) is a chorioretinal disease affecting mostly middle age males. It is marked by the serous detachment of the neurosensory layer at the macula.
Chhablani J., Cozzi M., Ivernizzi A., Lupidi M., Maltsev D. S., Manuel P. -E. A., Nkrumah G., Rasheed M. A., Singh S. R.   +8 more
core   +1 more source

Differentiating the Clinical and Variant Spectrum of Hardikar Syndrome From Other MED12‐Related Developmental Disorders

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The rare X‐linked female‐restricted Hardikar syndrome (HDKR, OMIM # 301068) is characterized by multiple congenital anomalies including orofacial clefts, gastrointestinal, genitourinary, and cardiac anomalies, but cognitive and neurobehavioral development is rarely impaired.
Tinne Warmoeskerken, Miel Theunis, Kris Van den Bogaert, Koenraad Devriendt, Jeroen Breckpot   +4 more
wiley   +1 more source

Анализа на мајчинските и акушерските фактори за ризик за прематурна ретинопатија кај прематуруси чија тежина е над 1500г и гестациска возраст над 30 недели [PDF]

, 2018
Retinopathy of Prematurity (ROP) is a major cause of preventable blindness in preterm infants. The incidence of ROP is increasing in developing countries due to increased survival of preterm infants.
Isjanovski, Igor, Isjanovski, Viktor
core   +2 more sources