Results 41 to 50 of about 157,772 (264)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Journal of Geometry and Physics, 2013 Thanks to the the author's previous work, it is possible to reconstruct a scheme from its derived category of perfect complexes, provided we equip the latter with its derived tensor product. The scheme is recovered by means of the ``triangular spectrum'' construction, \(\mathrm{Spc}(T)\), which can be applied to any abstract tensor triangulated ...
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Homotopy groups of Chow varieties [PDF]
American Journal of Mathematics, 2015 We show that a conjecture by Lawson holds, that is, the inclusion from the Chow variety $C_{p,d}({\Bbb P}^n)$ of all effective algebraic $p$-cycles of degree $d$ in $n$-dimensional projective space ${\Bbb P}^n$ to the space ${\mathcal C}_{p}({\Bbb P}^n)$ of effective algebraic $p$-cycles in ${\Bbb P}^n$ is $2d$-connected. As a result, the homotopy and
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Using the Chow Test to Analyze Regression Discontinuities [PDF]
Tutorials in Quantitative Methods for Psychology, 2008 The Chow Test (Chow, 1960) is a method well known in econometrics. It was originally designed to analyze the same variables obtained in two different data sets to determine if they were similar enough to be pooled together.
Howard H. Lee
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Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Hospital Readmission After Traumatic Brain Injury Hospitalization in Community‐Dwelling Older Adults
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the risk of hospital readmission after an index hospitalization for TBI in older adults. Methods Using data from the Atherosclerosis Risk in Communities (ARIC) study, we used propensity score matching of individuals with an index TBI‐related hospitalization to individuals with (1) non‐TBI hospitalizations (primary analysis)
Rachel Thomas +7 more
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Marine Drugs, 2019 Thioacetamide (TAA) is known to induce lipid accumulation in the liver. In the present study, we investigated the effects of magma seawater (MS) rich in minerals on hepatic lipid metabolism by evaluating lipogenic enzymes regulated by sterol regulatory ...
Minji Woo +4 more
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Documenta Mathematica, 1996 We develop a generalization of the classical Chow groups in order to have available some standard properties for homology theories: long exact sequences, spectral sequences for fibrations, homotopy invariance and intersections. The basis for our constructions is Milnor's K -theory.
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