Results 61 to 70 of about 166,399 (264)
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
The complexity of higher Chow groups
Canadian Mathematical Bulletin, 2022 AbstractLet $X/{\mathbb C}$ be a smooth projective variety. We consider two integral invariants, one of which is the level of the Hodge cohomology algebra $H^*(X,{\mathbb C})$ and the other involving the complexity of the higher Chow groups ${\mathrm {CH}}^*(X,m;{\mathbb Q})$ for $m\geq 0$ .
Da Silva, Genival jun., Lewis, James D.
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Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Marine Drugs, 2019 Thioacetamide (TAA) is known to induce lipid accumulation in the liver. In the present study, we investigated the effects of magma seawater (MS) rich in minerals on hepatic lipid metabolism by evaluating lipogenic enzymes regulated by sterol regulatory ...
Minji Woo +4 more
doaj +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Cartier-Dieudonné theory for Chow groups.
Journal für die reine und angewandte Mathematik (Crelles Journal), 1985 Let k be a perfect field of positive characteristic, X a smooth projective variety over k and \({\mathcal C}\) the category of augmented artinian local k-algebras. For \(A\in {\mathcal C}\) let \({\mathcal K}^ s_{n,X\times A/X}\) be the sub-sheaf of the sheaf of Quillen's K-groups on \(X\times_{spec k}spec A\) which is locally generated by Steinberg ...
openaire +1 more source
On flat pullbacks for Chow groups
Proceedings - Mathematical Sciences, 2022 It is a fundamental property of the Chow groups of algebraic schemes that they are contra-functorial with respect to flat morphisms between schemes. While the pullback homomorphism is easy to define at the level of algebraic cycles, the crucial step is to show that the pullback of cycles preserves rational equivalence, so that it descends to the Chow ...
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FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan +5 more
wiley +1 more source