Results 221 to 230 of about 5,633,674 (291)

A Clinical Study of Decellularized Tissue Engineering Hyaline Cartilage Graft (dLhCG) for Articular Cartilage Repair

Advanced Science, EarlyView.
ABSTRACT Current clinical approaches for knee cartilage repair are often limited by hypertrophy and fibrosis in the regenerated tissues. A decellularized tissue‐engineered hyaline cartilage graft (dLhCG), composed of a type II collagen‐based extracellular matrix, has been developed to overcome this limitation.
Zhen Zhang, Gong Cheng, Wenyong Fei, Qiuzhen Liang, Liang Zhang, Kegui Liu, Jihang Dai, Bo Cong, Xu Hu, Zhonglian Wu, Jialu Zhang, Jinlan Cui, Hang Yao, Dong‐An Wang, Jingcheng Wang, Tao Sun, Jiang Zheng   +16 more
wiley   +1 more source

Endoplasmic reticulum stress is associated with cardiac effects of bisphenol S independently of a high-fat diet. [PDF]

Histochem Cell Biol
Alexandre-Santos B, Dos Santos Reis G, Ferraz LM, da Silva MEL, Lima GF, Brito FCF, Stockler-Pinto MB, da Nóbrega ACL, Miranda-Alves L, Magliano DC, Frantz EDC.   +10 more
europepmc   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

SM17, an anti-interleukin-17 receptor B antibody, ameliorates pathogenesis of chronic rhinosinusitis with nasal polyps and idiopathic pulmonary fibrosis <i>via</i> Th2/Th17 dual modulation. [PDF]

ERJ Open Res
Lam LH, Li W, Chow KC, Au WYD, Wu WC, Gandhi Sethuraman MI, Nawabjan SA, Choi WY, Chow BKC, Leung SO, Hui CW.   +10 more
europepmc   +1 more source

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source

The metabokine β-aminoisobutyric acid mediates exercise performance and skeletal muscle adaptation through a PGC1α-BAIBA-PPARδ axis. [PDF]

Nat Commun
Daou HN, Watt NT, Gad SA, MacCannell AD, Ali A, Cheng C, Fernando RL, Futers TS, Khetarpal SA, Gallagher H, Chinait LD, Moriscot AS, Knuiman P, Manusama K, Mensink M, Teh I, Schneider JE, Cubbon R, Taylor GS, West DJ, Beech DJ, Bowen TS, Roberts LD.   +22 more
europepmc   +1 more source

Sustainable Materials Design With Multi‐Modal Artificial Intelligence

Advanced Science, EarlyView.
Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu, Tianshuo Wei, Yan Ge, Bo Peng, Yue Li, Maolin Wang, Peng Wen, Chao Yang, Ye Wei   +8 more
wiley   +1 more source

KBN2201 Attenuates High-Fat Diet-Induced Adipose Tissue Expansion and Body Weight Gain in Male Mice. [PDF]

Int J Mol Sci
Kim M, Heo JH, Chang SH, Lee SY, Kim J, Park C, Lee Y, Shin MG, Kim JS, Choi MR, Lee SR.   +10 more
europepmc   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Unifying Composition and Process Design: A Heterogeneous Graph Neural Network for Discovering High‐Performance Cu Alloys

Advanced Science, EarlyView.
By overcoming the fixed‐path limitations of conventional machine learning, a heterogeneous graph neural network fundamentally reconstructs material data representation. Integrating variable processing sequences with intrinsic elemental features, this framework enables exploratory optimization across high‐dimensional spaces.
Jie Yin, Qian Lei, Wei Yan, Yue Li, Tong Xie, Shuang Zhou, Chong Wang, Bram Hoex, Qiang Long, Caoyang Jiang, Min Song, Zhou Li, Zhangwei Wang   +12 more
wiley   +1 more source