Results 141 to 150 of about 2,781,563 (238)

Toward the Use of Real‐World Data for Regulatory and HTA Decision‐Making: Experiences and Recommendations from Six EU‐Funded Projects

Clinical Pharmacology &Therapeutics, EarlyView.
Real‐world data are increasingly important for regulatory and health technology assessment decision‐making, yet their effective use across Europe remains limited by technical, methodological, regulatory, and societal challenges. Drawing on the experiences of six Horizon Europe projects in the MetReal cluster, this review summarizes common barriers and ...
Martin Russek, Jonas Peltner, Kerstin Pfeifer, Theodoros N. Arvanitis, Dirk De Valck, Sieta T. de Vries, Michel Dumontier, Vera Ehrenstein, Omaima El Hakouni, Gregory Epiphaniou, Gokhan Ertaylan, Joana Fernandes, Scott Hansen, Stuart Harrison, Erzsébet Horváth‐Puhó, Saif Ul Islam, Pekka Kahri, Julia K. Mader, Carsten Maple, Nikolaos Matragkas, Shivani Misra, Peter G.M. Mol, Anne Paakinaho, Sami Pakarinen, Martina Radanović, Evy Reviers, Kathrine Kold Sørensen, Marco Spruit, Christina Tikka, Anna‐Maija Tolppanen, Christian Torp‐Pedersen, Mirna Vela, Thuan Vo, Puriya Daniel Würtz Yazdanfard, Britta Haenisch   +34 more
wiley   +1 more source

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis

Hepatology, EarlyView., 2022
Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres, Cristina Ortiz, Nadine Bachtler, Wenyi Gu, Leon D. Grünewald, Nico Kraus, Robert Schierwagen, Christoph Hieber, Caroline Meier, Olaf Tyc, Maximilian Joseph Brol, Frank Erhard Uschner, Bart Nijmeijer, Christoph Welsch, Marie‐Luise Berres, Carmen Garcia‐Ruiz, Jose Carlos Fernandez‐Checa, Christian Trautwein, Thomas J. Vogl, Stefan Zeuzem, Jonel Trebicka, Sabine Klein   +21 more
wiley   +1 more source

A Multilevel Framework of Employee Environmental Initiatives: The Role of Departmental Climate, Departmental Management's Green Leadership, and Corporate Environmental Responsibility

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study develops a multilevel framework to examine how employees' discretionary environmental initiatives are shaped by organizational and departmental contexts. Using survey data from 150 employees across 25 organizations, we integrate organizational climate and leadership theories to investigate the effects of Corporate Environmental ...
Yousef Eiadat
wiley   +1 more source

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Christian ethics in the Ukrainian private law

, 2012
У статті проведено аналіз змісту окремих статей цивільного, сімейного та трудового права на предмет втілення в їх нормах християнських, етичних та релігійних засад суспільства.
Комісій, М.М.
core   +1 more source

When Aviation CSR Efforts Are Not Enough: How Do We Inspire Airline Passengers to Offset Their Travel Footprints?

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Voluntary carbon offsetting programs (VCOPs) are available for airline passengers who want to take action and offset their scope 3 emissions. Yet, their uptake is very limited. In this study, we propose an integrated theoretical model involving the norm activation theory and protection motivation theory to understand airline passengers ...
Eric Tchouamou Njoya, Michael Adu Kwarteng, Alex Ntsiful, Abderrahmane Sadou, Marina Efthymiou   +4 more
wiley   +1 more source

CSR Sustainability Reporting and Enterprise Value: The Moderating Role of Regulatory Quality in the European Policy Landscape

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The study looks into the relationship between the extent of CSR Sustainability Reporting and Enterprise Value (EV) among European listed companies. The introduction of the Corporate Sustainability Reporting Directive (CSRD) 2022/2464/EU and the European Sustainability Reporting Standards (ESRS) has significantly heightened the demand for ...
Chiara Pia Saraò, Antonietta Trecca, Christian Favino, Antonio Corvino   +3 more
wiley   +1 more source

Readability of German Sustainability Reports: The Role of ESG Performance and Audit Committee Characteristics

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This paper examines whether firms' environmental, social and governance (ESG) performance and audit committee (AC) characteristics—size, number of meetings, attendance rate at meetings, and gender diversity—are associated with the readability of sustainability reports.
Julian Kordisch, Reiner Quick
wiley   +1 more source

Internationalising the teacher education curriculum: An analysis of syllabi and student experiences

The Curriculum Journal, EarlyView.
Abstract Internationalisation has increasingly become a key dimension of quality in initial teacher education (ITE) programmes. Although it is recognised as a means to strengthen future teachers' competencies and expand their professional knowledge, it remains underdeveloped in practice.
Nafsika Alexiadou, Mai Trang Vu
wiley   +1 more source

Further Extensive Evaluation of GHB‐Pentose as a Novel Biomarker for the Extended Detection of GHB Intake/Administration in Forensic Casework

Drug Testing and Analysis, EarlyView.
Analysis (LC–MS/MS, multiple reaction monitoring [MRM], hydrophilic interaction liquid chromatography [HILIC], and reversed‐phase [RP]) of 2414 authentic forensic urine samples demonstrated that GHB‐pentose (GHB‐P) is a highly specific marker of exogenous GHB exposure.
Katja Gimmler, Lana Brockbals, Sandra N. Poetzsch, Francesco Bavato, Laura K. Schnider, Dario A. Dornbierer, Oliver G. Bosch, Boris B. Quednow, Erich Seifritz, Christian Steuer, Thomas Kraemer, Andrea E. Steuer   +11 more
wiley   +1 more source