Developmental heterogeneity of embryonic neuroendocrine chromaffin cells and their maturation dynamics [PDF]
Frontiers in Endocrinology, 2022 During embryonic development, nerve-associated Schwann cell precursors (SCPs) give rise to chromaffin cells of the adrenal gland via the “bridge” transient stage, according to recent functional experiments and single cell data from humans and mice ...
Natalia Akkuratova +7 more
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High signal-to-noise imaging of spontaneous and 5 ns electric pulse-evoked Ca2+ signals in GCaMP6f-expressing adrenal chromaffin cells isolated from transgenic mice. [PDF]
PLoS ONE, 2023 In studies exploring the potential for nanosecond duration electric pulses to serve as a novel modality for neuromodulation, we found that a 5 ns pulse triggers an immediate rise in [Ca2+]i in isolated bovine adrenal chromaffin cells.
Ciara Viola +5 more
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The Role of Nicotinic Receptors on Ca2+ Signaling in Bovine Chromaffin Cells [PDF]
Current Issues in Molecular BiologyChromaffin cells have been used as a physiological model to understand neurosecretion in mammals for many years. Nicotinic receptors located in the cells’ membrane are stimulated by acetylcholine, and they participate in the exocytosis of chromaffin ...
Amparo Gil +3 more
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Intestinal microbiota modulates adrenomedullary response through Nod1 sensing in chromaffin cells [PDF]
iScience, 2021 Summary: The intestinal microbiota closely interacts with the neuroendocrine system and exerts profound effects on host physiology. Here, we report that nucleotide-binding oligomerization domain 1 (Nod1) ligand derived from intestinal bacteria modulates ...
Chen Xiang +7 more
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Sub-quantal release is not dominant during prolonged depolarization in adrenal chromaffin cells [PDF]
Biophysical ReportsExocytosis, which mediates important functions like synaptic transmission and stress responses, has been postulated to release all transmitter molecules in the vesicle in the “all-or-none” quantal hypothesis.
Lisi Wei +5 more
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v-SNARE function in chromaffin cells. [PDF]
Pflugers Arch, 2018 Vesicle fusion is elementary for intracellular trafficking and release of signal molecules, thus providing the basis for diverse forms of intercellular communication like hormonal regulation or synaptic transmission. A detailed characterization of the mechanisms underlying exocytosis is key to understand how the nervous system integrates information ...
Dhara M, Mohrmann R, Bruns D.
europepmc +4 more sources
Long-term in vitro 2D-culture of SDHB and SDHD-related human paragangliomas and pheochromocytomas
PLoS ONE, 2022 The neuroendocrine tumours paraganglioma and pheochromocytoma (PPGLs) are commonly associated with succinate dehydrogenase (SDH) gene variants, but no human SDH-related PPGL-derived cell line has been developed to date.
Jean-Pierre Bayley +9 more
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Basal and Stress-Induced Network Activity in the Adrenal Medulla In Vivo
Frontiers in Endocrinology, 2022 The adrenal medulla plays a critical role in mammalian homeostasis and the stress response. It is populated by clustered chromaffin cells that secrete epinephrine or norepinephrine along with peptides into the bloodstream affecting distant target organs.
Jose R. Lopez Ruiz +4 more
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Further Characterization of Dopamine Release by Permeabilized PC 12 Cells [PDF]
, 1987 Rat pheochromocytoma cells (PC 12) permeabilized with staphylococcal α-toxin release [3H]dopamine after addition of micromolar Ca2+. This does not require additional Mg2+-ATP (in contrast to bovine adrenal medullary chromaffin cells).
Ahnert-Hilger G. +18 more
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PLoS ONE, 2023 Sympathetic neurons and endocrine chromaffin cells of the adrenal medulla are catecholaminergic cells that derive from the neural crest. According to the classic model, they develop from a common sympathoadrenal (SA) progenitor that has the ability to ...
Stella Shtukmaster, Katrin Huber
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