Release of vasopressin from isolated permeabilized neurosecretory nerve terminals is blocked by the light chain of botulinum A toxin [PDF]
The intracellular action on exocytosis of botulinim A toxin and constituent chains was studied using permeabilized isolated nerve endings from the rat neural lobe. The release of the neuropeptide vasopressin was measured by radioimmunoassay.
Dayanithi, G.+4 more
core +6 more sources
ABSTRACT Background Primary aldosteronism (PA) is a prevalent yet frequently underdiagnosed cause of secondary hypertension, affecting up to 10% of hypertensive individuals and contributing to increased cardiovascular risk. Accurate diagnosis is vital, as unilateral PA cases typically require surgical intervention, while bilateral disease is managed ...
Zin Htut+14 more
wiley +1 more source
3',5'-Cyclic Adenosine Monophosphate- and Ca2+-Calmodulin-Dependent Endogenous Protein Phosphorylation Activity in Membranes of the Bovine Chromaffin Secretory Vesicles: Identification of Two Phosphorylated Components as Tyrosine Hydroxylase and Protein Kinase Regulatory Subunit Type II [PDF]
: Membranes of the secretory vesicles from bovine adrenal medulla were investigated for the presence of the endogenous protein phosphorylation activity. Seven phosphoprotein bands in the molecular weight range of 250,000 to 30,000 were observed by means ...
Amy C. M.+27 more
core +1 more source
Xenogeneic donors, a largely untapped resource, would solve many of the problems associated with the limited availability of human donor tissue for neural transplantation.
John D. Ortega+2 more
doaj +1 more source
Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases
HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang+4 more
wiley +1 more source
Kinetics of exocytosis in adrenal chromaffin cells [PDF]
Upon repetitive or maintained stimulation, chromaffin cells secrete catecholamines initially at a very high rate which then relaxes with multiple kinetic components. The complex kinetics are often modeled as resulting from the successive depletion of several functional pools of secretory granules which may reflect specific protein-mediated steps in ...
Kevin D. Gillis+2 more
openaire +4 more sources
Platelet granule exocytosis: A comparison with chromaffin cells
The rapid secretion of bioactive amines from chromaffin cells constitutes an important component of the fight or flight response of mammals to stress.
Jennifer eFitch-Tewfik+1 more
doaj +1 more source
In Arabidopsis, FORMIN HOMOLOGY PROTEIN 5‐labeled secretory vesicles and phosphatidylinositol 4,5‐bisphosphate (PI(4,5)P2) form a self‐reinforcing loop, where vesicles deliver the phosphatidylinositol 4‐phosphate 5‐kinase AtPIP5K4 to promote PI(4,5)P2 production, which in turn facilitates vesicle attachment to the plasma membrane, highlighting a novel ...
Yuwan Zhao+6 more
wiley +1 more source
Exocytosis from permeabilized bovine adrenal chromaffin cells is differently modulated by guanosine 5'-[gamma-thio]triphosphate and guanosine 5'-[beta gamma-imido]triphosphate [PDF]
1. In bovine adrenal chromaffin cells made permeable either to molecules less than or equal to 3 kDa with alphatoxin or to proteins less than or equal to 150 kDa with streptolysin O, the GTP analogues guanosine 5'-[beta gamma-imido]triphosphate (p[NH]ppG)
Ahnert-Hilger, G.+5 more
core
Differentiation of Chromaffin Progenitor Cells to Dopaminergic Neurons
The differentiation of dopamine-producing neurons from chromaffin progenitors might represent a new valuable source for replacement therapies in Parkinson's disease.
Vladimir Vukicevic+12 more
doaj +1 more source