Results 71 to 80 of about 32,833 (259)

The hemodynamically-regulated vascular microenvironment promotes migration of the steroidogenic tissue during its interaction with chromaffin cells in the zebrafish embryo. [PDF]

PLoS ONE, 2014
BACKGROUND: While the endothelium-organ interaction is critical for regulating cellular behaviors during development and disease, the role of blood flow in these processes is only partially understood.
Chih-Wei Chou, You-Lin Zhuo, Zhe-Yu Jiang, Yi-Wen Liu   +3 more
doaj   +1 more source

Approach to the Management of Gastrointestinal Manifestations in Patients With Phaeochromocytoma and Paraganglioma

Clinical Endocrinology, Volume 103, Issue 1, Page 21-35, July 2025.
ABSTRACT Objective Managing gastrointestinal symptoms in patients with phaeochromocytoma and paraganglioma (PPGL) is challenging due to the risk of catecholaminergic crisis with many commonly prescribed medications, especially in functional tumours.
Monica Majumder, Cherie Chiang, Grace Kong, Michael Michael, Nirupa Sachithanandan, Emma Boehm   +5 more
wiley   +1 more source

Hypoxia in the Initiation and Progression of Neuroblastoma Tumours [PDF]

, 2020
Neuroblastoma is the most frequent extracranial solid tumour in children, causing 10% of all paediatric oncology deaths. It arises in the embryonic neural crest due to an uncontrolled behaviour of sympathetic nervous system progenitors, giving rise to ...
Gómez Muñoz, María Ángeles, Huertas Castaño, Carlos, Pardal Redondo, Ricardo, Vega Moreno, Francisco Manuel   +3 more
core   +1 more source

Annexin A2 Egress during Calcium-Regulated Exocytosis in Neuroendocrine Cells

Cells, 2020
Annexin A2 (AnxA2) is a calcium- and lipid-binding protein involved in neuroendocrine secretion where it participates in the formation and/or stabilization of lipid micro-domains required for structural and spatial organization of the exocytotic ...
Marion Gabel, Cathy Royer, Tamou Thahouly, Valérie Calco, Stéphane Gasman, Marie-France Bader, Nicolas Vitale, Sylvette Chasserot-Golaz   +7 more
doaj   +1 more source

Differentiation in neuroblastoma: diffusion-limited hypoxia induces neuro-endocrine secretory protein 55 and other markers of a chromaffin phenotype. [PDF]

PLoS ONE, 2010
Neuroblastoma is a childhood malignancy of sympathetic embryonal origin. A high potential for differentiation is a hallmark of neuroblastoma cells. We have previously presented data to suggest that in situ differentiation in tumors frequently proceeds ...
Fredrik Hedborg, Reiner Fischer-Colbrie, Nurtena Ostlin, Bengt Sandstedt, Maxine G B Tran, Patrick H Maxwell   +5 more
doaj   +1 more source

Single‐Cell Atlas Reveals Tumorigenic Profiles and Immune Dynamics of Adrenal Incidentalomas

Advanced Science, Volume 12, Issue 22, June 12, 2025.
Single‐cell RNA sequencing reveals cellular heterogeneity in adrenal incidentalomas, identifying distinct tumor cell populations. Clusterin is recognized as a biomarker for adrenocortical tumors, correlating with established markers. MYCN‐positive clusters in pheochromocytomas indicated poorer survival.
Meng Wang, Guangmin Zheng, Xiaoyong Hu, Feng Tian, Tuo Li, Zheng Zhang, Kan Gong, Shiwei Chen, Lin Yuan, Yu Qi, Lin Li, Daofu Cheng, Liu Liu, Fuqiang Liu, Yujing Sun, Xiangdong Fang, Ruxing Zhao, Bing Liu, Chao Zhang   +18 more
wiley   +1 more source

Functional characterization of the catalytic site of the tetanus toxin light chain using permeabilized adrenal chromaffin cells [PDF]

, 1993
The molecular events underlying the inhibition of exocytosis by tetanus toxin were investigated in permeabilized adrenal chromaffin cells. We found that replacement of amino acid residues within the putative zinc binding domain of the tetanus toxin light
Ahnert-Hilger, Ahnert-Hilger, Ahnert-Hilger, Alder, Alder, Anderegg, Archer, Barbara Höhne-Zell, Baumert, Bennett, Binz, Bittner, Bittner, Bittner, Bommert, Brigitte Stecher, Brose, Coleman, Cushman, Dayanithi, Dayanithi, Eisel, Eisel, Elferink, Fö, Facchiano, Facchiano, Greenberg, Hö, Hata, Jahn, Jongeneel, Knaus, Kurazono, Link, Lorand, Manfred Gratzl, Matteoli, Mochida, Mochida, Niemann, Sö, Sü, Sanders, Schiavo, Schiavo, Schiavo, Stecher, Stecher, Stecher, Stecher, Thomas, Thomas, Ushkaryov, Vallee, Weller, Weller, Wright   +57 more
core   +1 more source

Spatiotemporal distribution of neural crest cells in the common wall lizard Podarcis muralis

Developmental Dynamics, Volume 254, Issue 6, Page 551-567, June 2025.
Abstract Background Neural crest cells (NCCs) are migratory embryonic stem cells that give rise to a diverse set of cell types. Here we describe the dynamic distribution of NCCs in developing embryos of the common wall lizard Podarcis muralis inferred from 10 markers.
Robin Pranter, Nathalie Feiner
wiley   +1 more source

SOX2+ sustentacular cells are stem cells of the postnatal adrenal medulla

Nature Communications
Renewal of the catecholamine-secreting chromaffin cell population of the adrenal medulla is necessary for physiological homeostasis throughout life. Definitive evidence for the presence or absence of an adrenomedullary stem cell has been enigmatic.
Alice Santambrogio, Yasmine Kemkem, Thea L. Willis, Ilona Berger, Maria Eleni Kastriti, Louis Faure, John P. Russell, Emily J. Lodge, Val Yianni, Bence Kövér, Rebecca J. Oakey, Barbara Altieri, Stefan R. Bornstein, Charlotte Steenblock, Igor Adameyko, Cynthia L. Andoniadou   +15 more
doaj   +1 more source

Case Series of Patients With FGFR1‐Related Pheochromocytoma and Paraganglioma With a Focus on Biochemical, Imaging Signatures and Treatment Options

Clinical Endocrinology, Volume 102, Issue 6, Page 626-634, June 2025.
ABSTRACT Pheochromocytoma and paraganglioma (together PPGL) are tumours with a high degree of heritability. Genetic landscape is divided into three clusters, cluster 1 (Krebs/pseudohypoxia signalling pathway), cluster 2 (kinase signalling pathway) and cluster 3 (Wnt signalling pathway).
Sakshi Jhawar, Abhishek Jha, Sara Talvacchio, Junne Kamihara, Jaydira Del Rivero, Karel Pacak   +5 more
wiley   +1 more source