Results 91 to 100 of about 991,372 (400)

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Statins as anti‐tumor agents: A paradigm for repurposed drugs

Cancer Reports
Background Statins, frequently prescribed medications, work by inhibiting the rate‐limiting enzyme HMG‐CoA reductase (HMGCR) in the mevalonate pathway to reduce cholesterol levels.
Sneha Tripathi, Ekta Gupta, Sanjeev Galande   +2 more
doaj   +1 more source

Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

Journal of Cell Biology, 1999
The loss of chromosomal integrity from DNA double-strand breaks introduced into mammalian cells by ionizing radiation results in the specific phosphorylation of histone H2AX on serine residue 139, yielding a specific modified form named γ-H2AX.
E. Rogakou, C. Boon, C. Redon, W. Bonner
semanticscholar   +1 more source

The Structure of Chromatin [PDF]

Proceedings of the National Academy of Sciences, 1971
The DNA in chromatin of isolated thymus nuclei, and in two different preparations of deoxyribonucleoprotein extracted from chromatin, has been digested with DNase. By variation of the time of reaction and the concentration of enzyme, and by comparison of the action of the enzyme on (protein-free) DNA with its action on DNA complexed with protein in ...
openaire   +3 more sources

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

FEBS Letters, EarlyView.
Extracellular vesicles (EVs) mediate intercellular communication in tumor immune microenvironments. However, their role in B‐cell malignancies remains poorly defined, owing to biological complexity and technical challenges in EV isolation and analysis.
Daniel Bachurski, Michael Hallek
wiley   +1 more source

An HP1 isoform-specific feedback mechanism regulates Suv39h1 activity under stress conditions

Epigenetics, 2017
The presence of H3K9me3 and heterochromatin protein 1 (HP1) are hallmarks of heterochromatin conserved in eukaryotes. The spreading and maintenance of H3K9me3 is effected by the functional interplay between the H3K9me3-specific histone methyltransferase ...
Helena Raurell-Vila, Laia Bosch-Presegue, Jessica Gonzalez, Noriko Kane-Goldsmith, Carmen Casal, Jeremy P. Brown, Anna Marazuela-Duque, Prim B. Singh, Lourdes Serrano, Alejandro Vaquero   +9 more
doaj   +1 more source

In vitro Histone H3 Cleavage Assay for Yeast and Chicken Liver H3 Protease

Bio-Protocol, 2017
Histone proteins are subjected to a wide array of reversible and irreversible post-translational modifications (PTMs) (Bannister and Kouzarides, 2011; Azad and Tomar, 2014).
Sakshi Chauhan, Gajendra Azad, Raghuvir Tomar   +2 more
doaj   +1 more source

Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion

Nature Biotechnology, 2019
Understanding complex tissues requires single-cell deconstruction of gene regulation with precision and scale. Here, we assess the performance of a massively parallel droplet-based method for mapping transposase-accessible chromatin in single cells using
Ansuman T. Satpathy, Jeffrey M. Granja, K. Yost, Yanyan Qi, Francesca Meschi, Geoffrey P. McDermott, B. Olsen, Maxwell R Mumbach, Sarah E. Pierce, M. Corces, Preyas Shah, Jason C. Bell, Darisha Jhutty, Corey M. Nemec, Jun Wang, Li Wang, Y. Yin, P. Giresi, A. Chang, Grace X. Y. Zheng, W. Greenleaf, Howard Y. Chang   +21 more
semanticscholar   +1 more source

Toward a molecular understanding of yeast silent chromatin : roles for H4K16 acetylation and the Sir3 C-terminus [PDF]

, 2012
Discrete regions of the eukaryotic genome assume a heritable chromatin structure that is refractory to gene expression. In budding yeast, silent chromatin is characterized by the loading of the Silent Information Regulatory (Sir) proteins (Sir2, Sir3 and
Oppikofer, Mariano
core   +1 more source

Origin of life: β‐sheet amyloid conformers as the primordial functional polymers on the early Earth and their role in the emergence of complex dynamic networks

FEBS Letters, EarlyView.
The amyloid world hypothesis of the origin‐of‐life posits that the first functional polymers on the early Earth were structurally stable cross‐β‐sheet‐based peptide amyloids capable of Darwinian‐like evolution. Peptide amyloids display self‐replication and information transfer, as well as catalytic, adaptive, and evolutive properties.
Carl Peter J. Maury
wiley   +1 more source