Results 101 to 110 of about 496,209 (318)

Spatial-ATAC-seq: spatially resolved chromatin accessibility profiling of tissues at genome scale and cellular level [PDF]

, 2021
Yanxiang Deng, Marek Bartošovič, Sai Ma, Di Zhang, Yang Liu, Xiaoyu Qin, Graham Su, Mina L. Xu, Stephanie Halene, Joseph Craft, Gonçalo Castelo‐Branco, Rong Fan   +11 more
openalex   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Multiple structures of RNA polymerase II isolated from human nuclei by ChIP-CryoEM analysis

Nature Communications
RNA polymerase II (RNAPII) is a central transcription enzyme that exists as multiple forms with or without accessory factors, and transcribes the genomic DNA packaged in chromatin.
Tomoya Kujirai, Junko Kato, Kyoka Yamamoto, Seiya Hirai, Takeru Fujii, Kazumitsu Maehara, Akihito Harada, Lumi Negishi, Mitsuo Ogasawara, Yuki Yamaguchi, Yasuyuki Ohkawa, Yoshimasa Takizawa, Hitoshi Kurumizaka   +12 more
doaj   +1 more source

Function and Selectivity of Bromodomains in Anchoring Chromatin-Modifying Complexes to Promoter Nucleosomes [PDF]

, 2002
Ahmed H. Hassan, Philippe Prochasson, Kristen E. Neely, Scott Galasinski, Mark Chandy, Michael J. Carrozza, Jerry L. Workman   +6 more
openalex   +1 more source

Spatial chromatin accessibility sequencing resolves high-order spatial interactions of epigenomic markers

, 2023
Yeming Xie, Fengying Ruan, Yaning Li, Meng Luo, Chen Zhang, Zhichao Chen, Zhe Xie, Zhe Weng, Weitian Chen, Wenfang Chen, Yitong Fang, Yuxin Sun, Mei Guo, Juan Wang, Shouping Xu, Hongqi Wang, Chong Tang   +16 more
openalex   +1 more source

SEX CHROMATIN [PDF]

Journal of Medical Genetics, 1964
openaire   +2 more sources

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

The synergistic action of HDAC inhibitor with cisplatin impedes survival and proliferation of drug-tolerant persister in gastric and liver cancer cells

Clinical Epigenetics
Acquired therapy resistance is a dynamic process associated with early epigenetic modifications reshaping gene transcription across multiple cellular pathways, ultimately giving rise to drug-tolerant persister (DTP) cells.
Anjali Singh, Abhiram Natu, Flevia Anthony, Hemalatha Muthu, Bharat Khade, Duane T. Smoot, Hassan Ashktorab, Sanjay Gupta   +7 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Silencing of Chromatin Assembly Factor 1 in Human Cells Leads to Cell Death and Loss of Chromatin Assembly during DNA Synthesis

, 2004
Arman Nabatiyan, Torsten Krude
openalex   +1 more source