Results 121 to 130 of about 834,176 (358)

Chromatin topology defines estradiol-primed progesterone receptor and PAX2 binding in endometrial cancer cells

, 2022
Alejandro La Greca, Nicolás Bellora, François Le Dily, Rodrigo Jara, A. Silvina Nacht, Javier Quilez Oliete, José Luis Villanueva‐Cañas, Enrique Vidal, Gabriela Merino, Cristóbal Fresno, Inti Tarifa Reischle, Griselda Vallejo, Guillermo P. Vicent, Elmer A. Fernández, Miguel Beato, Patricia Saragüeta   +15 more
openalex   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The chromatin accessibility landscape of pistils and anthers in rice [PDF]

, 2022
Guanqun Wang, Xiaozheng Li, Wei Shen, Man‐Wah Li, Mingkun Huang, Jianhua Zhang, Haoxuan Li   +6 more
openalex   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Genome-wide mapping and cryo-EM structural analyses of the overlapping tri-nucleosome composed of hexasome-hexasome-octasome moieties

Communications Biology
The nucleosome is a fundamental unit of chromatin in which about 150 base pairs of DNA are wrapped around a histone octamer. The overlapping di-nucleosome has been proposed as a product of chromatin remodeling around the transcription start site, and ...
Masahiro Nishimura, Takeru Fujii, Hiroki Tanaka, Kazumitsu Maehara, Ken Morishima, Masahiro Shimizu, Yuki Kobayashi, Kayo Nozawa, Yoshimasa Takizawa, Masaaki Sugiyama, Yasuyuki Ohkawa, Hitoshi Kurumizaka   +11 more
doaj   +1 more source

p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells [PDF]

, 2013
Andrei N. Mardaryev, Michał R. Gdula, Joanne L. Yarker, Vladimir U. Emelianov, Krzysztof Poterlowicz, Andrey A. Sharov, Tatyana Sharova, Julie A. Scarpa, Pierre Chambon, Vladimir A. Botchkarev, Michael Y. Fessing   +10 more
openalex   +1 more source

A MRG-operated chromatin switch at SOC1 attenuates abiotic stress responses during the floral transition [PDF]

, 2021
Javier Barrero‐Gil, Alfonso Mouriz, Raquel Piqueras, Julio Salinas, José A. Jarillo, Manuel Piñeiro   +5 more
openalex   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Nucleosome spacing can fine-tune higher-order chromatin assembly

Nature Communications
Cellular chromatin displays heterogeneous structure and dynamics, properties that control diverse nuclear processes. Models invoke phase separation of conformational ensembles of chromatin fibers as a mechanism regulating chromatin organization in vivo ...
Lifeng Chen, M. Julia Maristany, Stephen E. Farr, Jinyue Luo, Bryan A. Gibson, Lynda K. Doolittle, Jorge R. Espinosa, Jan Huertas, Sy Redding, Rosana Collepardo-Guevara, Michael K. Rosen   +10 more
doaj   +1 more source

Statistical mechanics of nucleosome ordering by chromatin structure-induced two-body interactions

, 2011
One-dimensional arrays of nucleosomes (DNA-bound histone octamers separated by stretches of linker DNA) fold into higher-order chromatin structures which ultimately make up eukaryotic chromosomes.
Chereji, Răzvan V., Locke, George, Morozov, Alexandre V., Tolkunov, Denis   +3 more
core   +1 more source