Results 121 to 130 of about 971,786 (390)
Histone crosstalk directed by H2B ubiquitination is required for chromatin boundary integrity [PDF]
, 2011 Genomic maps of chromatin modifications have provided evidence for the partitioning of genomes into domains of distinct chromatin states, which assist coordinated gene regulation.
Hair, A. +3 more
core +4 more sources
Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source
Definitions, 2020 Rating: Not Rated Archive Warning: Graphic Depictions Of Violence Category: F/M, Gen, M/M Fandom: Sherlock (TV) Relationship: Sherlock Holmes/John Watson, Established Relationship(s), Molly Hooper/Greg Lestrade Character: Sherlock Holmes, John Watson ...
Paul M. Wassarman, Alan P. Wolfe
semanticscholar +1 more source
Remodeling is at the heart of chromatin [PDF]
Epigenetics, 2011 Chromatin modifications are integral elements of chromosome structure and its function and the vasculature depends on tissue-specific genome regulation for its development. A general concept for the de-regulation of chromatin modifications in cardiac and vascular disease is also emerging.
openaire +3 more sources
Chromatin Preparation and Chromatin Immuno-precipitation from Drosophila Embryos
, 2016 This protocol provides specific details on how to perform Chromatin immunoprecipitation (ChIP) from Drosophila embryos. ChIP allows the matching of proteins or histone modifications to specific genomic regions.
Iovino, N., Latrielle, D., Löser, E.
core +1 more source
Minor Loops in Major Folds: Enhancer-Promoter Looping, Chromatin Restructuring, and Their Association with Transcriptional Regulation and Disease. [PDF]
, 2015 The organization and folding of chromatin within the nucleus can determine the outcome of gene expression. Recent technological advancements have enabled us to study chromatin interactions in a genome-wide manner at high resolution.
Ahituv, Nadav, Matharu, Navneet
core +1 more source
Molecular Oncology, EarlyView.Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova +26 more
wiley +1 more source
Resolving the 3D landscape of transcription-linked mammalian chromatin folding
bioRxiv, 2019 Chromatin folding below the scale of topologically associating domains (TADs) remains largely unexplored in mammals. Here, we used a high-resolution 3C-based method, Micro-C, to probe links between 3D-genome organization and transcriptional regulation in
Tsung-Han S. Hsieh +6 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha +10 more
wiley +1 more source
Quantitative Analysis of Single-Molecule Force Spectroscopy on Folded Chromatin Fibers
, 2015 Single-molecule techniques allow for picoNewton manipulation and nanometer accuracy measurements of single chromatin fibers. However, the complexity of the data, the heterogeneity of the composition of individual fibers and the relatively large ...
Andresen, Kurt +2 more
core +2 more sources